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91.
Clustering analysis of temporal gene expression data is widely used to study dynamic biological systems, such as identifying sets of genes that are regulated by the same mechanism. However, most temporal gene expression data often contain noise, missing data points, and non-uniformly sampled time points, which imposes challenges for traditional clustering methods of extracting meaningful information. In this paper, we introduce an improved clustering approach based on the regularized spline regression and an energy based similarity measure. The proposed approach models each gene expression profile as a B-spline expansion, for which the spline coefficients are estimated by regularized least squares scheme on the observed data. To compensate the inadequate information from noisy and short gene expression data, we use its correlated genes as the test set to choose the optimal number of basis and the regularization parameter. We show that this treatment can help to avoid over-fitting. After fitting the continuous representations of gene expression profiles, we use an energy based similarity measure for clustering. The energy based measure can include the temporal information and relative changes of the time series using the first and second derivatives of the time series. We demonstrate that our method is robust to noise and can produce meaningful clustering results. 相似文献
92.
围绕车辆调度问题多目标优化这一主题,依据企业现有的GPS定位系统,设计一种基于实数编码和精英保留策略,综合应用外部惩罚函数法的多目标遗传算法.并于其中创新性的引入基因校验算子,避免了重复车次的产生.程序使用Java语言编制,后台数据库使用oracle.实验结果表明,该算法能够充分满足系统硬约束条件,快速收敛于目标约束,完成车辆的优化调度,具有较强的实用价值. 相似文献
93.
改进的粒子群优化算法在QoS选播路由中的应用 总被引:4,自引:0,他引:4
QoS选播路由问题是一个非线性的组合优化问题,已被证明是NP完全问题.提出一种基于改进的粒子群优化的多QoS选播路由算法.算法引入一种特殊相加算子,让较差的路径能够不断向较好的路径学习,使算法尽可能向全局最优者靠近;设计一种随机变异算子,通过对全局极值进行随机变异,保证了粒子的多样性,提高了算法跳出局部最优解的能力.实验结果表明,该算法是可行和有效的,能够在资源预留的基础上较好地满足用户对带宽和时延的要求. 相似文献
94.
95.
利用Delta算子离散化系统采样周期是显式参数的特点,基于Delta算子方法对永磁直线同步电机(PMLSM)不同采样周期下的非脆弱保性能速度控制器的统一化设计问题进行研究.以线性矩阵不等式(LMI)给出该控制器的存在条件.通过对PMLSM闭环系统极点的分析,表明所设计的非脆弱保性能速度控制器不但能保证PMLSM在其对象参数和控制器参数同时发生范数有界摄动时闭环系统仍保持渐近稳定,而且系统的二次型性能指标上界的数学期望值不超过某个给定的上界,而不考虑控制器参数摄动情况所设计的控制器在其参数摄动时闭环系统将无法保持稳定. 相似文献
96.
This paper proposes a novel method, called model transduction, to directly transfer pose between different meshes, without the need of building the skeleton configurations for meshes. Different from previous retargetting methods, such as deformation transfer, model transduction does not require a reference source mesh to obtain the source deformation, thus effectively avoids unsatisfying results when the source and target have different reference poses. Moreover, we show other two applications of the model ... 相似文献
97.
几类强弱缓冲算子的构造方法及其内在联系 总被引:7,自引:0,他引:7
基于最基本的缓冲算子x(k)d=∑ni=kωix(i)/∑ni=kωi变形,获得了几类范围大大拓宽的实用缓冲算子的构造方法,并揭示了这几类缓冲算子的内在联系.同时揭示了强化缓冲与弱化缓冲的对应关系,即指数γ由正到0,由0到负的变化,导致缓冲算子由弱(强)化到不变化,由不变化到强(弱)化的过程,揭示了由量变到质变的过程.研究表明,现有的大量缓冲算子都是所构造的缓冲算子的特例,此外还包括许多与常见文献中类型迥然不同的新算子. 相似文献
98.
With consideration that the controller parameters may vary from the designed value when the controller is realized, based on Lyapunov stability theory, a design method of nonfragile guaranteed cost control for a class of Delta operator-formulated uncertain time-delay systems is studied. A sufficient condition for the existence of the nonfragile guaranteed cost controller is given. A numeric example is then given to illustrate the effectiveness and the feasibility of the designed method. The results show that even if the parameters of the designed controller are of variations, the closed-loop system is still asymptotically stable and the super value of the cost function can also be obtained, while the closed-loop system will be unstable if the variations of the controller parameters are not considered when the controller is designed. The nonfragile guaranteed cost controller derived from the traditional shift operator method may cause the closed-loop system to be unstable, while the nonfragile guaranteed cost controller based on Delta operator method can avoid the unstable problem of the closed-loop system. 相似文献
99.
100.
In this paper, we introduce and consider a new class of mixed variational inequalities involving four operators, which are called extended general mixed variational inequalities. Using the resolvent operator technique, we establish the equivalence between the extended general mixed variational inequalities and fixed point problems as well as resolvent equations. We use this alternative equivalent formulation to suggest and analyze some iterative methods for solving general mixed variational inequalities. We study the convergence criteria for the suggested iterative methods under suitable conditions. Our methods of proof are very simple as compared with other techniques. The results proved in this paper may be viewed as refinements and important generalizations of the previous known results. 相似文献