Energy and spectral dynamics in decaying compressible turbulence

The statistical properties of decaying compressible turbulence are investigated by direct numerical simulations of flow in a periodic cube. Starting with fully developed turbulence for various microscale Reynolds numbersR , rms Mach numbersM, and small- and large-scale compressive ratiosr _CS andr _CL , we find that the kinetic energy exhibits an exponential decay in time. Interactions between the compressive and rotational components of kinetic energy are weaker than self-interactions of the respective components. The energy spectrum of rotational component obeys the same Kolmogorov similarity law as for incompressible turbulence and forced compressible turbulence. The form of the energy spectrum of the compressive component, on the other hand, depends strongly onM. As the turbulence decays freely,R andM decrease in time butr _CS andr _CL tend to some universal values.     

具有随机丢包的网络化多自主体系统的一致性

研究具有随机丢包的网络化多自主体系统的均方一致性问题,其中不同自主体间的通信通道具有相同的丢包情况并且均服从马尔可夫(Markov)分布。首先,利用系统变换和迭代方法,得到了系统达到均方一致的一个初等充要条件。然后,利用矩阵理论和图论知识,如果拓扑图含有有向生成树,则可以将系统的均方一致性转化成一个线性Markov跳变系统的均方稳定性,并且可以建立线性矩阵不等式形式的均方可镇定准则。最后,通过相应的仿真实例说明了所得结论的可行性。     

单晶镍纳米薄膜单向拉伸破坏的分子动力学模拟

应用分子动力学方法模拟了单晶镍纳米薄膜受单向拉伸破坏的过程, 得出纳米尺度单晶镍薄膜的应力-应变关系、能量演化曲线和镍薄膜构型的变化及微损伤的形成和扩展过程. 模拟采用原子镶嵌势描述原子间作用, 得到镍单晶薄膜的弹性模量, 分析了拉伸过程中系统原子能量、应力变化和外荷载的关系. 结果表明: 纳米薄膜的自由表面影响拉伸过程中原子的运动和薄膜整体力学性能, 纳米薄膜破坏的几何特征是原子空位的连接和晶胞缺陷的扩展; 单晶的断裂接近脆性断裂, 模拟得到纳米薄膜的断裂强度符合Griffith脆性断裂的能量平衡理论.     

固氟氯化铵焙烧法从包头稀土矿中回收稀土的动力学

研究了固氟氯化铵焙烧法分解包头混合型稀土精矿回收稀土的动力学.结果表明:固氟焙砂的氯化反应过程符合Bagdasarym提出的区域反应速率模型,氯化反应过程经过了两个串联反应步骤,且反应生成物的核按一个方向长大;反应速率方程遵从Erofeev方程的串联反应步骤模型,反应表观活化能Ea为36.831 KJ·mol-1,过程控制步骤是内扩散控制.     

The Role of Rigid Residues in Modulating TEM-1 β-Lactamase Function and Thermostability

The relationship between protein motions (i.e., dynamics) and enzymatic function has begun to be explored in β-lactamases as a way to advance our understanding of these proteins. In a recent study, we analyzed the dynamic profiles of TEM-1 (a ubiquitous class A β-lactamase) and several ancestrally reconstructed homologues. A chief finding of this work was that rigid residues that were allosterically coupled to the active site appeared to have profound effects on enzyme function, even when separated from the active site by many angstroms. In the present work, our aim was to further explore the implications of protein dynamics on β-lactamase function by altering the dynamic profile of TEM-1 using computational protein design methods. The Rosetta software suite was used to mutate amino acids surrounding either rigid residues that are highly coupled to the active site or to flexible residues with no apparent communication with the active site. Experimental characterization of ten designed proteins indicated that alteration of residues surrounding rigid, highly coupled residues, substantially affected both enzymatic activity and stability; in contrast, native-like activities and stabilities were maintained when flexible, uncoupled residues, were targeted. Our results provide additional insight into the structure-function relationship present in the TEM family of β-lactamases. Furthermore, the integration of computational protein design methods with analyses of protein dynamics represents a general approach that could be used to extend our understanding of the relationship between dynamics and function in other enzyme classes.     

Prediction of Functional Consequences of Missense Mutations in ANO4 Gene

The anoctamin (TMEM16) family of transmembrane protein consists of ten members in vertebrates, which act as Ca²⁺-dependent ion channels and/or Ca²⁺-dependent scramblases. ANO4 which is primarily expressed in the CNS and certain endocrine glands, has been associated with various neuronal disorders. Therefore, we focused our study on prioritizing missense mutations that are assumed to alter the structure and stability of ANO4 protein. We employed a wide array of evolution and structure based in silico prediction methods to identify potentially deleterious missense mutations in the ANO4 gene. Identified pathogenic mutations were then mapped to the modeled human ANO4 structure and the effects of missense mutations were studied on the atomic level using molecular dynamics simulations. Our data show that the G80A and A500T mutations significantly alter the stability of the mutant proteins, thus providing new perspective on the role of missense mutations in ANO4 gene. Results obtained in this study may help to identify disease associated mutations which affect ANO4 protein structure and function and might facilitate future functional characterization of ANO4.     

欠驱动异构式下肢康复机器人动力学分析及参数优化

针对现有外骨骼机器人人机自由度不匹配和关节对中性差的问题,提出欠驱动下肢康复机器人. 欠驱动机器人只有4个直线驱动,驱动的直线运动通过推杆和人机连接机构转化为人下肢在矢状面内的屈伸运动,带动人体进行步态康复训练. 建立机器人系统的人机耦合模型,进行模型的动力学分析,对人机耦合模型中影响动力学结果的参数进行分析,建立驱动力与肢体推动力之间的关系模型,并以推力系数最大为目标进行参数分析与优化,得到最佳的结构参数. 根据优化后的结构参数搭建康复机器人实验系统,对髋、膝关节驱动力与角度进行对比. 实验结果表明最大髋关节角度误差为2.9°,最大膝关节角度误差为6.4°,最大误差均约为9%,验证了动力学模型和参数优化结果的正确性.     

工业设计决策网络构建及其动态演化仿真

针对工业设计过程多阶段方案决策的意见演化问题,融合复杂网络理论建立工业设计决策网络模型,通过意见动力学进行决策意见动态演化仿真.基于图论建立设计决策有权无向网络,以网络效率变化确定决策者权重,借助意见距离识别设计决策网络节点信任集合,利用加权平均意见驱动设计决策网络更新与演化. 提出工业设计决策网络的演化仿真流程,结合产品设计方案决策数据进行动态仿真分析,结果表明：信任阈值决定设计决策网络拓扑构成,随着网络演化的进行,决策个体间意见差异逐步缩小并最终达成共识;设计决策网络分析能够析出噪声节点及其意见变化,在实际产品设计决策中应重点关注;意见演化能够辅助确定工业设计方案决策轮次,明确方案在各指标上的表现并识别设计改进方向;仿真分析有助于发现设计决策中的关键因素和意见演化规律.     

一种基于RSA安全可行的（t，n）门限签名方案*

分析了大多数RSA门限群签名方案存在的缺陷,RSA的模数是n,φ(n)是秘密参数,参加部分签名的成员无法知晓,求Lagrange相关系数存在困难,也为建立门限RSA密码体制带来困难.提出一种新的方案以克服上述困难,通过求ai无须在求Lagrange相关系数时进行求逆运算,使该方案在保证安全的前提下变得可行实用.     

精确定位的高带宽新型音圈电机驱动器研究

为了在极高磁道密度（TPI）的硬盘中快速寻道定位、读取数据,研发了一种新型高带宽驱动器组件.该新型高带宽驱动器的音圈电机（VCM）具有独特的音圈结构和磁极（体）排列.在电磁设计中,应用三维有限元分析法（FEA）对一些关键电磁参数及主要结构尺寸进行了优化;预测了系统的动态性能.分析表明,新型音圈电机驱动器产生的电磁力形成了纯力矩,降低了轴承和轴上的反作用力,与传统驱动器相比,更好地抑制了影响伺服带宽的横向准刚性体震动模式（QR模式）,使驱动系统能在高TPI下快速跟踪和精确定位.实验测试了系统的频率响应特性,与理论设计符合得较好.