自由曲面数控加工刀具轨迹生成的约束条件分析

在提出自由曲面数控加工过程和刀具轨迹的规划原则情况下,分析无干涉控制、恒表面速度进给、伺服能力控制和相邻加工曲线影响等轨迹控制的约束条件,实时对轨迹的生成进行系统优化控制。通过系统分析刀具轨迹生成的约束条件,为刀具轨迹优化控制提供决策,对提高自由曲面的切削质量和加工效率具有重要意义。     

非球面主反射镜检测用支撑结构的优化设计

在工程分析软件SSAP91上,应用有限元分析的方法,优化设计出Φ500mm非球面主反射镜的支撑结构,将此使用在干涉测量中,为非球面的数控加工提供可靠的面形误差数据。     

旋转锉螺旋刃加工时机床运动的分析

本文讨论了各类旋转挫数控加工时，旋转锉几何形状与数控机床各坐标轴之间的函数关系，从而为数控加工各类旋转锉提供了控制用数学模型。按此数学模型建立的控制模型，在多坐标简易数控机床上加工出完全符合图纸要求的工件。     

The efficacy of back propagation neural network with delta bar delta learning in predicting the wear of carbide inserts in face milling

Face milling is a process predominantly affected by dynamic variation of cutting forces, thermo-mechanical shocks and vibration leading to catastrophic tool failure along with gradual wear of the inserts. Keeping in view the industrial importance of this process, it is necessary to devise suitable methods to predict in advance the onset of tool failure without grossly impairing the machining set-up and the job. Hence, the applicability of back propagation neural network with delta bar delta learning rule for faster convergence has been studied with the above objective. The multi sensor based tool condition monitoring strategy shows that the learning rate adaptation scheme combined with the selection of suitable process parameters drastically reduces the training time of the artificial neural network without dispensing with the prediction accuracy.     

A DPSK demodulator for biomedical application

In this study, a differential phase-shift-keying (DPSK) demodulator, which is implemented by digital circuit, is proposed. A differential voltage clipper is used to generate narrow pulses at the extremum of the received modulated signal. Regarding the DPSK signal, the outputs of the clipper have double frequency. In order to halve the frequency, a frequency divider is applied to get synchronous clock. Two binary counters are used to detect phase variation; the data are recovered after two times sampling. This technique removes the need for voltage controlled oscillator (VCO). The proposed demodulator is postlayout simulated in a 0.18-μm CMOS process, with a power of 64 μW and active area of 68 × 70 μm². The demodulator recovers 10 Mb/s data rate at 10-MHz carrier frequency using a 1.8-V power supply.     

离散变量优化设计的改进斐波那契遗传算法

根据工程实际，充分考虑规范规定的约束条件和各项技术标准要求，建立离散变量结构优化模型。针对遗传算法在迭代过程中经常出现未成熟收敛、振荡、随机性太大和迭代过程缓慢等缺点，提出一种新的遗传算子——转基因算子，用于对遗传算法的改进；提出一种离散变量结构优化设计的斐波那契算法，并与遗传算法结合在一起解决问题。优化设计结果表明，这种改进斐波那契遗传算法的收敛特性得到很好的改善，即发挥了斐波那契算法省时、局部搜索能力强的特点，又发挥了遗传算法全局性好的特点，是有效的工程结构优化设计方法。     

基于边界控制的Gn连续过渡曲面的构造

讨论了基于重新参数化局部基曲面线性组合构造G^n连续过渡曲面时重新参数化局部基曲面的形状对于过渡曲面的边界和形状的影响；提出了采用能量最小法使过渡曲面的边界弯曲最小来确定重新参数化局部基曲面参数域的方法，并提出相应的重新参数化局部基曲面的确定方法，从而构造较好的过渡曲面。     

高精度数控直流电流源

介绍一种高精度，可预置，可步进的数字显示直流电流源的软件、硬件制作方法。该系统主要利用单片机AT89S52作为控制部件。文中给出了硬件电路和软件流程。     

连接板自动排料加工系统

以AutoCAD为开发平台，结合Visual C ，Visual Lisp等软件，开发了一套集排料和切割于一体的连接板自动排料加工系统，文中主要阐述了系统的总体结构，人机交互界面设计，数据管理模块，自动排料算法及数控自动编程模块等。     

High‐Security Nanocluster for Switching Photodynamic Combining Photothermal and Acid‐Induced Drug Compliance Therapy Guided by Multimodal Active‐Targeting Imaging

High‐security nanoplatform with enhanced therapy compliance is extremely promising for tumor. Herein, using a simple and high‐efficient self‐assembly method, a novel active‐targeting nanocluster probe, namely, Ag₂S/chlorin e6 (Ce6)/DOX@DSPE‐mPEG₂₀₀₀‐folate (ACD‐FA) is synthesized. Experiments indicate that ACD‐FA is capable of specifically labeling tumor and guiding targeting ablation of the tumor via precise positioning from fluorescence and photoacoustic imaging. Importantly, the probe is endowed with a photodynamic “on‐off” effect, that is, Ag₂S could effectively quench the fluorescence of chlorin e6 (89.5%) and inhibit release of ¹O₂ (92.7%), which is conducive to avoid unwanted phototoxicity during transhipment in the body, and only after nanocluster endocytosed by tumor cells could release Ce6 to produce ¹O₂. Moreover, ACD‐FA also achieves excellent acid‐responsive drug release, and exhibits eminent chemo‐photothermal and photodynamic effects upon laser irradiation. Compared with single or two treatment combining modalities, ACD‐FA could provide the best cancer therapeutic effect with a relatively low dose, because it made the most of combined effect from chemo‐photothermal and controlled photodynamic therapy, and significantly improves the drug compliance. Besides, the active‐targeting nanocluster notably reduces nonspecific toxicity of both doxorubicin and chlorin e6. Together, this study demonstrates the potency of a newly designed nanocluster for nonradioactive concomitant therapy with precise tumor‐targeting capability.