人体声发射定位技术的研究

从人体声发射技术与医学检测的特点出发,将人体骨科疾病的诊断和人体声发射结合起来,提出了具体的研究问题和解决手段。通过BL—420生物机能实验系统采集人体骨骼中的声发射信号,对该声发射信号利用互相关法计算时差,从而实现声源定位。     

基于三维点云数据的虚拟人台中间体模型的构建

利用[TC]2三维人体扫描仪采集了华东地区72名40～49岁B体型女性的三维人体数据,对[TC]2扫描获得的三维人体＊.wrl数据文件进行预处理,并建立三维直角坐标系.采用模糊逻辑算法中三角形线形隶属度函数进行噪点的过滤,将人体数据进行标准化处理,建立人体躯干部位特征矩阵.通过计算特征矩阵的均值获得人台中间体特征矩阵,经过对称化处理获得最终的人台中间体特征矩阵.采用Delaunay三角刨分算法将人台中间体特征点进行三角刨分,通过计算点或面的法线向量来光滑曲面获得最终的三维虚拟人台中间体模型.此方法可用于不同规格系列人台三维模型的制作.     

基于向量法解决机器人正向运动学教学难题

为解决机器人正向运动学教学中大学生对位姿矩阵以及刚体变换难以理解的难题,以向量法建立了刚体的位姿矩阵,并以向量法推导了刚体绕空间任意轴线旋转的变换矩阵.以此为基础,证明了矩阵左乘和右乘所对应的不同刚体运动,最终利用矩阵右乘导出了D-H变换矩阵,从而建立机器人学正向运动学方程.     

煤矸石中金属元素对人体健康影响的研究

矿业活动是环境中金属元素的主要来源,而煤矸石是我国矿业固体废料中产生量、累计积存量和占地面积最大的固体废物,它含有铁、钠、锌、铜、锰等22种有害微量元素。分析煤矸石中这些金属元素在环境中的迁移转化途径及其对生物体的毒性效应,对人体健康影响的研究具有重要意义。本文详细阐述了金属元素对生物体(植物和人)的生物效应,重点分析了煤矸石中几种常见的金属元素在环境中的迁移途径及它们对人体健康的影响和毒性效应,并提出了防治煤矸石环境污染的相应对策。     

Discordance Rate of HER2 Status in Primary Gastric Carcinomas and Synchronous Lymph Node Metastases: A Multicenter Retrospective Analysis

Background: The assessment of human epidermal growth factor receptor 2 (HER2) gene amplification is essential in order to identify those patients affected by advanced gastric cancer who may benefit from Trastuzumab targeted therapy. Materials and Methods: With the aim to investigate the concordance rate in HER2 status between primary gastric carcinoma (GC) and synchronous lymphnode metastases, we investigated HER2 status in a cohort of 108 surgical formalin-fixed paraffin-embedded specimens of GC and matched synchronous metastatic lymph nodes collected from three different units of Anatomic Pathology in southern of Italy. Fleiss-Cohen weighted k statistics were used to assess the concordance rate of HER2 status. Results: HER2 amplification was observed in 17% of primary GCs and the overall concordance rate with corresponding nodal metastases was 90.74%. Changes in HER2 status between primary GC and matched synchronous metastases were evidenced in 10 (9.26%) cases. Of these, 6 cases were HER2 amplified in the primary GC and not amplified in the metastases, while 4 were HER2 not amplified in the primary tumour and amplified in the lymph node metastases. Conclusions: Although at present the simultaneous determination of HER2 in advanced gastric cancer and corresponding metastatic lymph nodes is not mandatory, the possibility that the synchronous metastases of GC have a different HER2 status from that of the primary tumour is of remarkable significance; Indeed this may have influence on the therapeutic management and prognosis of the patients.     

Efficient adsorptive extraction materials by surface protein-imprinted polymer over silica gel for selective recognition/separation of human serum albumin from urine

In this study, we report the development of adsorptive extraction materials by surface protein-imprinted polymers (MIPs) over silica gel for selective recognition/separation of human serum albumin (HSA) from urine. The HSA-imprinted polymers prepared on silica particle had at interface between the silica gel and different MIPs greatly produced enrichment for the binding of protein from the urine. The solid-phase extraction of the optimized polymer layer was prepared by copolymerization of methacrylic acid (MAA), acrylamide (AAm), and dimethylaminoethylmethacrylate (DMAEMA) and a crosslinker methylenebisacrylamide (MBA) at the mole ratio of 1:158:88 (T:M:C) and showed moderate affinity (<10⁴ order M⁻¹) toward target protein HSA and selectivity. Four analogues, egg white albumin (EWA), bovine serum albumin (BSA), lysozyme (Lyz), and creatinine (Cre) were selected to study the binding efficiency of MIPs in single and binary protein solutions. We studied the influence on recognition ability for HSA and found that prepolymer mixture and matrix flexibility of the optimized thin polymer layer (35 ± 10 nm) on the submicrosilica particles. The high-binding affinity (Q_MIP, 86.7 mg g⁻¹) and fast kinetics (180 min) were observed for this synthesized HSA-MIP when compared with other reported HSA-MIPs in surface imprinting (5.9 and 11.3 mg g⁻¹) and epitope surface imprinting (46.6 mg g⁻¹) methods. We demonstrated the application in real and synthetic urine samples that the approach allowed the efficient adsorption of HSA in real urine (129.48 mg g⁻¹) is almost double to the binding of HSA in synthetic urine (67.84 mg g⁻¹). Apart from this, only minor interference of Cre (2.74 mg g⁻¹) was observed, eventhough Cre is the final metabolite in urine. These adsorptive submicrosilica materials have potential in the pharmaceutical industry and clinical analysis applications. © 2018 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2019 , 136, 46894.     

基于运动生物力学的护膝设计评价

目的 旨在探究穿戴三种典型护膝导致的青年人和老年人下肢运动生物力学的变化,为膝关节护具设计提供相关建议。方法 利用VICON三维运动捕捉系统、ATMI三维测力台、Pedar-X足底压力测试系统等设备对运动学、动力学和足底压力参数进行采集,根据青年组和老年组实验数据所显示出来的变化趋势总结出三种护膝对不同年龄段人群的影响。结果 护膝B和护膝C对两组受试者造成的影响比护膝A更为显著,两组受试者穿戴护膝后膝关节屈曲方向负荷均增大,老年组踝关节和足弓负荷增大,其肢体稳定性也受到影响。结论 三种典型护膝对不同年龄段人群造成了不同的影响,护膝设计应当参照所对应的生物力学变化,考虑人群、左右肢差异等因素,综合分析其对膝关节组织和肌肉组织的影响,以提高人机耦合性。     

搬运机器人运动学仿真系统

本机器人仿真系统是为用于浇铸生产线上的搬运机器人研制的.本文在对搬运机器人结构分析的基础上,简要介绍了搬运机器人运动学仿真系统,分析了搬运机器人的动作过程,并从图形学的角度,对机器人动作过程进行了图形仿真,给出了仿真结果.