Nonlinear performance evaluation model for throughput of AQM scheme using full factorial design approach

The performance of active queue management (AQM) is measured in terms of throughput, delay, queue size, and loss rate. We have carried out the optimized performance measure of throughput for AQM scheme random early detection (RED) using full factorial design (FDD) technique that is a new approach of performance analysis particularly for congestion control algorithms. We have considered the input factors, viz, buffer size, maximum threshold, and the number of file transfer protocol (FTP) sources for the evaluation of RED that can be used for other AQM schemes, viz, adaptive RED, three‐section RED (TRED), and adaptive queue management with random dropping (AQMRD). The effect of each input factor as well as their interactions are evaluated using factorial design technique that results to obtain the nonlinear equation for performance measure in terms of input factors buffer size, maximum threshold, and the number of FTP sources. Finally, we show the contour plots for variation of performance measure throughput (steady state) from minimum to maximum values with respect to the different setting of input parameters.     

Targeting NF-κB-Inducing Kinase (NIK) in Immunity,Inflammation, and Cancer

NF-κB-inducing kinase (NIK), the essential upstream kinase, which regulates activation of the noncanonical NF-κB pathway, has important roles in regulating immunity and inflammation. In addition, NIK is vital for maintaining cellular health through its control of fundamental cellular processes, including differentiation, growth, and cell survival. As such aberrant expression or regulation of NIK is associated with several disease states. For example, loss of NIK leads to severe immune defects, while the overexpression of NIK is observed in inflammatory diseases, metabolic disorders, and the development and progression of cancer. This review discusses recent studies investigating the therapeutic potential of NIK inhibitors in various diseases.     

On the polynomial solvability of distributionally robust k-sum optimization

In this paper, we define a distributionally robust k-sum optimization problem as the problem of finding a solution that minimizes the worst-case expected sum of up to the k largest costs of the elements in the solution. The costs are random with a joint probability distribution that is not completely specified but rather assumed to be known to lie in a set of probability distributions. For k=1, this reduces to a distributionally robust bottleneck optimization problem while for k=n, this reduces to distributionally robust minimum sum optimization problem. Our main result is that for a Fréchet class of discrete marginal distributions with finite support, the distributionally robust k-sum combinatorial optimization problem is solvable in polynomial time if the deterministic minimum sum problem is solvable in polynomial time. This extends the result of Punnen and Aneja [On k-sum optimization, Oper. Res. Lett. 18(5)(1996), pp. 233–236] from the deterministic to the robust case. We show that this choice of the set of distributions helps preserve the submodularity of the k-sum objective function which is an useful structural property for optimization problems.     

Efficient Evaluation of Monitoring Top-t Most Influential Places

The continuous top-t most influential place (CTtMIP)query is defined formally and solved efficiently in this paper.A CTtMIP query continuously monitors the t places with the maximum influence from the ...     

Lactoperoxidase-mediated degradation of single-walled carbon nanotubes in the presence of pulmonary surfactant

Carbon nanotubes (CNTs) may elicit inflammatory responses following pulmonary exposure. Conversely, enzymatic biodegradation of CNTs by inflammatory cells has also been reported. The aim of this study was to study the degradation of oxidized single-walled CNTs (ox-SWCNTs) by lactoperoxidase (LPO), a secreted peroxidase present in the airways, and whether pulmonary surfactant affects this biodegradation. To this end, ox-SWCNTs were incubated in vitro with recombinant bovine LPO + H₂O₂ + NaSCN in the presence and absence of porcine lung surfactant (Curosurf®) and biodegradation was monitored using UV–Vis–NIR spectroscopy, Raman spectroscopy, and scanning electron microscopy. The interaction of recombinant LPO with bundles of ox-SWCNTs was confirmed by atomic force microscopy. Cell-free biodegradation of ox-SWCNTs was also observed ex vivo in murine bronchoalveolar lavage fluid in the presence of H₂O₂ + NaSCN. Our study provides evidence for biodegradation of ox-SWCNTs with a lung surfactant ‘bio-corona’ and expands the repertoire of mammalian peroxidases capable of biodegradation of ox-SWCNTs. These findings are relevant to inhalation exposure to these materials, as LPO serves as an important component of the airway defense system.     

基于2k修正和Canny边缘检测的图像隐写

针对信息安全,提出基于Canny边缘检测和2k修正的信息隐藏算法.秘密信息仅仅隐藏在边界像素上,首先利用Canny边缘检测算子检测载体图像的边缘,然后利用伪随机数序列对边缘像素进行重排.为了增强秘密信息的安全性,采用霍夫曼编码把秘密信息变成二进制位流.每个像素隐藏的位数由其灰度值确定.最后,为了增强隐写图像的视觉效果,采用2k修正法进一步减小隐写图像和载体图像之间的误差.实验证明提出的方法比LSB-2和文献[12]的方法更好.     

软土地基基坑挡土结构设计参数经验公式

土压力系数和土的水平抗力比例系数是基坑挡土结构设计的重要计算参数。土压力和土的水平抗力是与土的物理力学性质和挡土结构刚度、支撑、位移有着密切关系。本文通过挡土结构原位测试的实测土压力与挡土结构位移,经反分析逐一叠代得到的土压力系数与土的抗剪强度内摩擦角和土的水平抗力比例系数与挡土结构位移、土的抗剪强度内摩擦角,采用数理统计和相关关系分析方法,建立的土压力系数和水平抗力比例系数经验公式,对深基坑支护设计具有实用意义。     

Heads or Tails: Genotyping of Hepatitis C Virus Concerning the 2k/1b Circulating Recombinant Form

As different hepatitis C virus (HCV) genotypes respond differently to initiated therapy, correct HCV genotyping is essential. A potential risk for misclassification of the intergenotypic HCV circulating recombinant form (CRF) 2k/1b strains exists, depending on the genotyping method used. The aim was to investigate the differences in HCV genotyping methods with regard to CRF 2k/1b and to gain insight in the prevalence of the CRF 2k/1b. Genotyping results by Versant HCV Genotype Assay were compared with nonstructural protein 5B (NS5B) sequencing. In total, from November 2001 until March 2015, 3296 serum samples were analyzed by Versant HCV Genotype Assay. As misclassified CRF is harbored among HCV genotype 2, we further focused our search on 142 (4.3%) samples positive for HCV genotype 2. On 116 (81.7%) retrieved samples, the NS5B sequencing was performed. Twelve out of the 116 retrieved samples (10.3%) were classified as CRF 2k/1b by sequencing of the NS5B region. Ten of these 12 samples were originally misclassified as genotype 2a or 2c, while 2 of them were misclassified as genotype 2. Our results show that the current prevalence of CRF 2k/1b is underestimated. The importance of correct HCV genotyping is emphasized, considering the tailored choice of treatment regimen and overall prognosis.