Self-esteem stability and depressive symptoms in acute stroke rehabilitation: Methodological and conceptual expansion.

Objectives: Explore the relationship of self-esteem level, self-esteem stability, and other moderating variables with depressive symptoms in acute stroke rehabilitation. Measures: One hundred twenty participants completed measures of state self-esteem, perceived recovery, hospitalization-based hassles, impairment-related distress, and tendency to overgeneralize negative self-connotations of bad events. Self-report of depressive symptoms was collected at admission and on discharge. Four regression analyses explored the relationship of self-esteem level and stability and each of 4 moderating variables (perceived recovery, hassles, impairment-related distress, and overgeneralization) with depressive symptoms at discharge. Results: Analyses indicated significant 3-way interactions in the 4 regression models. In general, individuals with unstable high self-esteem endorsed greater depressive symptoms under conditions of vulnerability (e.g., lower perceived recovery) than did individuals with stable high self-esteem. Under conditions of vulnerability, participants with stable low self-esteem indicated the highest levels of depressive symptoms. Implications: Self-esteem level and stability interact with psychological, environmental, and stroke-specific variables to predict depressive symptoms at discharge from stroke rehabilitation. This suggests the viability of self-esteem stability in exploring depressive symptoms in this setting and the complexity of emotional adjustment early after stroke. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Melatonin-Based Therapeutics for Neuroprotection in Stroke

The present review paper supports the approach to deliver melatonin and to target melatonin receptors for neuroprotection in stroke. We discuss laboratory evidence demonstrating neuroprotective effects of exogenous melatonin treatment and transplantation of melatonin-secreting cells in stroke. In addition, we describe a novel mechanism of action underlying the therapeutic benefits of stem cell therapy in stroke, implicating the role of melatonin receptors. As we envision the clinical entry of melatonin-based therapeutics, we discuss translational experiments that warrant consideration to reveal an optimal melatonin treatment strategy that is safe and effective for human application.     

Detection of human serum albumin on protein array using scanning tunneling microscopy

Electrical detection of biological binding events, such as protein–protein interaction and DNA hybridization, has emerged as an alternative method to conventional colorimetric and fluorescence based methods. In this study, we demonstrate an electrical detection technique of protein array which can be simply extended for multifunctional measurements and detection of biological binding events on micro-scale array. Micro-contact technique was used for the fabrication of protein chip. The fabricated protein array on Au substrate was characterized by fluorescence microscopy and scanning tunneling microscopy (STM). The chip was designed to investigate immunocomplexes comprised of our model protein, human serum albumin (HSA), corresponding antibody fragments, and Au nanoparticle–antibody conjugates. The peak-like pulse obtained by electrical tunneling current between these complexes and the STM tip varies on the surface density of the bound complexes. Using the electrical detection technique based on STM, 100 fg/mL of HSA could be successfully detected by STM. Importantly, the proposed concept of measurement could allow multiple analyses of analytes at nano-scale array, which is difficult to be analyzed by conventional fluorescence based method.     

关于液压系统中“液阻”的探讨

以液压系统的液压压力、流量和功率为参量,借鉴欧姆定律提出“液阻”概念,并以此初步归纳了各种“导流”液压元器件的“液阻”共性.藉此各种液压元器件所共有的“液阻”属性,探讨了面向液压系统的数学运算及分析评估的可行性.     

Plasma Unesterified Fatty‐Acid Profile Is Dramatically and Acutely Changed under Ischemic Stroke in the Mouse Model

Although plasma biomarkers would facilitate rapid and accurate diagnosis of ischemic stroke for immediate treatment, no such biomarkers have been developed to date. In the present study, we tested our hypothesis that plasma unesterified fatty acids (FFA) are altered at early stages of acute ischemic stroke. Plasma was collected from mice 2 h after the permanent middle cerebral artery occlusion (pMCAo) onset, as well as from sham operated and control animals. After 2 h, pMCAo significantly changed the plasma FFA profile with the most dramatic 2‐ to 3‐fold relative increase in very long n‐3 and n‐6 FFA including 20:4n‐6, 22:4n‐6, 22:5n‐6, and 22:6n‐3. Changes in the plasma FFA profile are consistent with FFA liberation from brain phospholipid hydrolyzed under ischemic insult. These results identify, for the first time, the plasma FFA profile as a potential biomarker for an early ischemic stroke within the therapeutic window for thrombolytic treatment. Further studies are required to confirm its specificity and sensitivity in clinical settings.     

Group psychotherapy focusing on self-concept change following acquired brain injury: A pilot investigation.

Objective: The current study explored the effectiveness of a group therapy intervention that was focused specifically on self-concept changes following acquired brain injury (ABI). Method: Eighteen individuals in the postacute phase of recovery underwent a 6-week group therapy intervention and were administered a self-concept measure before and after the intervention. Results: Group members showed a significant increase (improvement) in self-concept ratings at the end of the group intervention. Conclusions: Although the results of this study suggest that this intervention may be helpful in improving self-concept following ABI, further exploration is clearly warranted. Future research is needed to investigate the impact of self-concept on emotional adjustment, participation in rehabilitation activities, and functional outcome. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

多接地点闪电的梯级先导与回击过程的研究

利用成像率为1000幅/s的高速数字化摄像系统和电场变化仪,对在一次回击过程中具有多个接地分支的闪电(MGPF)进行了研究。结果表明:MGPF回击前的梯级先导由包含2~4个脉冲的脉冲束组成,脉冲束间的时间间隔平均值约为26μs,脉冲间的时间间隔平均值约为5μs;广东MGPF回击过程中和的电荷量约为4.5C,青海的约为11C;广东MGPF发生比例为16.7%,青海的为17.6%;一次回击的多个接地分支多发生在首次回击。通过分析发现,MGPF的形成与闪电的梯级先导、连接过程等有重要关系。闪电在一次回击过程中具有多个接地分支对雷电防护方法和设计的改进提出了更高的要求。     

反辐射导弹毁伤能力评估研究

将反辐射导弹(anti-radiationmissile,ARM)的毁伤能力细化为爆破毁伤能力和破片杀伤能力;在分析反辐射导弹毁伤能力评估模型的基础上针对不同的炸点,建立了反辐射导弹的综合毁伤模型;并评估了4种典型反辐射导弹炸点在不同位置时的毁伤能力。     

220 kV江龙东线雷击跳闸分析

根据220kV江龙东线跳闸现场收集的杆塔尺寸、保护动作及接地电阻等资料，采用绕击几何电气模型和反击耐雷水平等理论，并结合GPS雷电信息系统提供的地闪雷电流值，分析了线路跳闸的原因，并提出了相关整改建议。     

OVSF码分配算法研究

提出1种优先选择极左碎片的信道化码分配算法,该算法用很简单的方式降低了码阻塞率。将新算法与已有的极左法和权重法进行比较,理论分析和计算机仿真表明,极左碎片法具有与极左法相近的简单性,在码阻塞率和公平性方面几乎与权重法一样好,是简单、高效和公平的综合性能最好的算法。该算法可应用于以OVSF码作为信道化码的各种DS-CDMA系统。