Design of experiments for bivariate binary responses modelled by Copula functions

Optimal design for generalized linear models has primarily focused on univariate data. Often experiments are performed that have multiple dependent responses described by regression type models, and it is of interest and of value to design the experiment for all these responses. This requires a multivariate distribution underlying a pre-chosen model for the data. Here, we consider the design of experiments for bivariate binary data which are dependent. We explore Copula functions which provide a rich and flexible class of structures to derive joint distributions for bivariate binary data. We present methods for deriving optimal experimental designs for dependent bivariate binary data using Copulas, and demonstrate that, by including the dependence between responses in the design process, more efficient parameter estimates are obtained than by the usual practice of simply designing for a single variable only. Further, we investigate the robustness of designs with respect to initial parameter estimates and Copula function, and also show the performance of compound criteria within this bivariate binary setting.     

Rectangle packing with additional restrictions

We formulate a generalization of the NP-complete rectangle packing problem by parameterizing it in terms of packing density, the ratio of rectangle areas, and the aspect ratio of individual rectangles. Then we show that almost all restrictions of this problem remain NP-complete and identify some cases where the answer to the decision problem can be found in constant time.     

Patterns for multigrid equidistributed functions: Application to general parabolas and length estimation

We show that for some special functions (called k-multigrid equidistributed functions), we can compute the limit of the frequency of patterns in the discretization of their graph, when the resolution tends to zero. This result is applied to parabolas. We deduce also that local length estimators almost never converge to the length for the parabolas.     

基于S3C2410的启动代码的研究

描述了将启动代码移植到基于S3C2410处理器目标板上的方法与过程。首先介绍了目标平台和Linux,接着介绍了交叉编译环境的建立原理,着重介绍了BootLoader的架构和功能,给出了启动代码vivi的配置和编译过程。     

Secretome analysis of novel IgE-binding proteins from Penicillium citrinum

The Penicillium genus of fungi is a frequently reported cause of allergic reactions. However, only a limited number of allergens have been reported. In Penicillium spp., many allergens show higher IgE-binding activity in culture filtrate extracts than in cellular extracts. In order to investigate the IgE-reactive profile of mold-sensitized patients, secreted IgE-reactive proteins from Penicillium citrinum were identified by 2-DE, serum immunoblotting, and nanoLC-MS/MS. Among the IgE-reactive spots, one known allergen, Pen c 13, and four novel allergens were identified. The cDNAs coding for Pen c 32 and Pen c 30 were cloned using designed primers based on nanoLC-MS/MS analysis. The amino acid sequences of Pen c 32 and Pen c 30 were, respectively, found to have extensive similarity with those of pectate lyases and catalases from various fungi. Native Pen c 30 was shown to have catalase activity and to bind to serum IgE from 48% of mold-allergic patients and induced immediate type skin reactions in a sensitized patient. Here, we present a proteome approach which resulted in the identification of four novel secreted allergens. These novel allergens might be useful in allergy diagnosis and in the treatment of mold-allergic disorders.     

On delay-derivative-dependent stability of systems with fast-varying delays

Stability of linear systems with uncertain bounded time-varying delays is studied under the assumption that the nominal delay values are not equal to zero. An input-output approach to stability of such systems is known to be based on the bound of the L₂-norm of a certain integral operator. There exists a bound on this operator norm in two cases: in the case where the delay derivative is not greater than 1 and in the case without any constraints on the delay derivative. In the present note we fill the gap between the two cases by deriving a tight operator bound which is an increasing and continuous function of the delay derivative upper bound d?1. For d→∞ the new bound corresponds to the second case and improves the existing bound. As a result, for the first time, delay-derivative-dependent frequency domain and time domain stability criteria are derived for systems with the delay derivative greater than 1.     

Nonsmooth optimization for multiband frequency domain control design

Multiband frequency domain synthesis consists in the minimization of a finite family of closed-loop transfer functions on prescribed frequency intervals. This is an algorithmically difficult problem due to its inherent nonsmoothness and nonconvexity. We extend our previous work on nonsmooth H_∞ synthesis to develop a nonsmooth optimization technique to compute local solutions to multiband synthesis problems. The proposed method is shown to perform well on illustrative examples.     

基于人类视觉感知特性的一种纹理图象分割方法

在纹理图象分割的研究领域中,基于人类视觉感知特性的图象分割方法是一个重要的新方向,本文给出了一种纹理图象分割的方法,设计了一组参数不同的2D最佳正交极可分方向滤波器来提取图象特征,然后经过四叉树平滑,用模糊C－均值聚类对图象进行分类,最后进行边缘确定,实验结果表明,这种方法能获得较好的分割效果。     

A reactive GRASP and path relinking for a combined production–distribution problem

An NP-hard production–distribution problem for one product over a multi-period horizon is investigated. The aim is to minimize total cost taking production setups, inventory levels and distribution into account. An integer linear model is proposed as a compact problem specification but it cannot be solved to optimality for large instances. Instead of using a classical two-phase approach (production planning and then route construction for each day), metaheuristics that simultaneously tackle production and routing decisions are developed: a GRASP (greedy randomized adaptive search procedure) and two improved versions using either a reactive mechanism or a path-relinking process. These algorithms are evaluated on 90 randomly generated instances with 50, 100 and 200 customers and 20 periods. The results confirm the interest of integrating production and distribution decisions, compared to classical two-phase methods. Moreover, reaction and path-relinking give better results than the GRASP alone.     

Limitations of nonlinear discrete periodic control for disturbance attenuation and robust stabilization

This paper presents a performance analysis of nonlinear periodically time-varying discrete controllers acting upon a linear time-invariant discrete plant. Time-invariant controllers are distinguished from strictly periodically time-varying controllers. For a given nonlinear periodic controller, a time-invariant controller is constructed. Necessary and sufficient conditions are given under which the time-invariant controller gives strictly better control performance than the time-invariant controller from which it was obtained, for the attenuation of l_p exogenous disturbances and the robust stabilization of l_p unstructured perturbations, for all p[1,∞].