Development of an ultrafast X‐ray computed tomography scanner system: Application for measurement of instantaneous void distribution of gas–liquid two‐phase flow

An ultrafast X‐ray computed tomography (CT) scanner has been developed. This scanner overcomes problems that occur in a transient or unsettled state, which make the conventional CT scanner inappropriate. To reduce the scanning time, this X‐ray CT system uses electronic switching of electron beams for X‐ray generation instead of the mechanical motion adopted by conventional CT scanners. The mechanical motion is a major obstacle to improving scanning speed. A prototype system with a scanning time of 3.6 ms was initially developed and confirmed to measure the dynamic events of two‐phase flow. However, an increased scanning speed is generally required for practical use in the thermal hydraulics research field. Therefore, an advanced type which can operate under the scanning time of 0.5 ms and can measure two‐phase flow with a velocity up to 4 to 5 m/s was developed. © 2000 Scripta Technica, Heat Trans Asian Res, 29(3): 155–165, 2000     

Characterization of a Novel Thermostable Dye-Linked l-Lactate Dehydrogenase Complex and Its Application in Electrochemical Detection

Flavoenzyme dye-linked l-lactate dehydrogenase (Dye-LDH) is primarily involved in energy generation through electron transfer and exhibits potential utility in electrochemical devices. In this study, a gene encoding a Dye-LDH homolog was identified in a hyperthermophilic archaeon, Sulfurisphaera tokodaii. This gene was part of an operon that consisted of four genes that were tandemly arranged in the Sf. tokodaii genome in the following order: stk_16540, stk_16550 (dye-ldh homolog), stk_16560, and stk_16570. This gene cluster was expressed in an archaeal host, Sulfolobus acidocaldarius, and the produced enzyme was purified to homogeneity and characterized. The purified recombinant enzyme exhibited Dye-LDH activity and consisted of two different subunits (products of stk_16540 (α) and stk_16550 (β)), forming a heterohexameric structure (α3β3) with a molecular mass of approximately 253 kDa. Dye-LDH also exhibited excellent stability, retaining full activity upon incubation at 70 °C for 10 min and up to 80% activity after 30 min at 50 °C and pH 6.5–8.0. A quasi-direct electron transfer (DET)-type Dye-LDH was successfully developed by modification of the recombinant enzyme with an artificial redox mediator, phenazine ethosulfate, through amine groups on the enzyme’s surface. This study is the first report describing the development of a quasi-DET-type enzyme by using thermostable Dye-LDH.     

Preparation and properties of ester or cyano group substituted ring-opening polymers and their hydrogenated derivatives

Ester or cyano substituted tetracyclo [4.4.0.1^2,5.1^7,10]dodec-3-enes (1) were synthesized and their metathesis ring-opening polymerization was examined. The tungsten-based ternary catalyst system polymerized them very well. The polymers showed high glass transition temperatures (T_g) and no evidence of crystallization (e.g., the T_g of the polymer derived from 8-methyl-8-methoxycarbonyl substituted monomer (1a) was 207°C, and colorless transparent films could be casted from the solution of the polymer). The stability of these high T_g polymers were too unstable, so practical thermal molding methods could not be applied to them. The hydrogenation of these polymers with a palladium catalyst decreased T_g and greatly increased thermal stability. The physical and thermal properties of the hydrogenated polymers were thoroughly investigated. Monomer 1 was successfully copolymerized with other cyclic olefins. The resultant copolymers were hydrogenated, giving thermally stable polymers. In all cases examined in this study, a decrease of T_g by hydrogenation was about 35°C, regardless of the monomer structure. These results indicate that the main-chain mobility is the major contribution to the decrease of T_g. © 1997 John Wiley & Sons, Inc. J Appl Polym Sci 66: 367–375, 1997     

Unexpected Pleiotropic Effects of SGLT2 Inhibitors: Pearls and Pitfalls of This Novel Antidiabetic Class

Sodium-glucose co-transporter 2 (SGLT2) inhibitors facilitate urine glucose excretion by reducing glucose reabsorption, leading to ameliorate glycemic control. While the main characteristics of type 2 diabetes mellitus are insufficient insulin secretion and insulin resistance, SGLT2 inhibitors have some favorable effects on pancreatic β-cell function and insulin sensitivity. SGLT2 inhibitors ameliorate fatty liver and reduce visceral fat mass. Furthermore, it has been noted that SGLT2 inhibitors have cardio-protective and renal protective effects in addition to their glucose-lowering effect. In addition, several kinds of SGLT2 inhibitors are used in patients with type 1 diabetes mellitus as an adjuvant therapy to insulin. Taken together, SGLT2 inhibitors have amazing multifaceted effects that are far beyond prediction like some emerging magical medicine. Thereby, SGLT2 inhibitors are very promising as relatively new anti-diabetic drugs and are being paid attention in various aspects. It is noted, however, that SGLT2 inhibitors have several side effects such as urinary tract infection or genital infection. In addition, we should bear in mind the possibility of diabetic ketoacidosis, especially when we use SGLT2 inhibitors in patients with poor insulin secretory capacity.     

Robust topology optimization of multi-material lattice structures under material and load uncertainties

Frontiers of Mechanical Engineering - Enabled by advancements in multi-material additive manufacturing, lightweight lattice structures consisting of networks of periodic unit cells have gained...     

THE CHARACTERISTIC EFFECTS OF VARIOUS IRON SULFIDE CATALYSTS IN COAL LIQUEFACTION

In order to investigate the effective mechanism of pyrite catalyst, coal liquefaction was conducted using a 500 ml autoclave. When the chemical structure characteristics of products and product yields are considered as a whole, deoxygenation and dealkylation are found to be enhanced in the presence of pyrite catalyst. Further, it is surmised that depolymerization is faster than the removal of heteroatoms.     

Experimental study on effect of elasticity on drag reduction and turbulent fluctuations in laminar-turbulent transition region in pipe flow of dilute polymer solutions

By utilizing the fact that physical properties exclusive of elasticity of dilute polyacrylamide solutions do not change with elapsed time after preparation, the effect of elasticity on drag reduction and turbulent fluctuations in pipe flow was investigated experimentally. The oscillations of axial velocity and velocity gradient and the drag reduction in the laminar-turbulent transition region are affected significantly by the value of elasticity. The laminar-turbulent transition region moves to a higher Reynolds number as the value of elasticity increases.     

Relationship between electron sensitivity and chemical structures of polymers as electron beam (EB) resists. V: Polyamides containing sulfur groups as positive eb resists

Polyamidethioethers were synthesized and evaluated as positive electron beam (EB) resists, The polyamidethioethers decomposed easily with EB exposure. At high doses (indicating low sensitivity), crosslinking reactions occurred for polyamidethioethers having C-S bonds produced by Michael addition, but the other polyamidethioethers did not crosslink. The C-S bonds produced by Michael addition may influence crosslinking rather than decomposition. The sensitivity of oxidized polyamidethioether was higher than that of the nonoxidized polymer with no change in resolution. The oxidized polyamidethioether had a high sensitivity and a high resolution, and is adaptable as a positive EB resist.     

Oblique Promax Rotation Applied to the Solutions in Multiple Correspondence Analysis

There are many approaches to formulate multiple correspondence analysis of multi-item categorical data. A lower-rank approximation approach gives the freedom for the oblique rotation of axes. In the current paper, we apply the oblique rotation of axes to a variable-by-dimension matrix to arrive at simple structure. This matrix is defined in either of two different manners, that is, by treating categories as variables or, alternatively, by treating items as variables. For each of these two options, the standardized inner products between dimensions and variables are used as the elements of the component structure matrix. We adopt a promax method for the oblique rotation. In this method, scores are rotated in such a way that the above matrix is matched with the target matrix obtained from the result of the varimax rotation.

     

The BC-chain method for representing combinators in linear space

Turner’s combinator implementation (1979) of functional programs requires the memory space of size Ω(n ²) in the worst case for translating given lambda expressions of lengthn to combinator graphs. In this paper a new idea named the BC-chain method for transferring actual arguments to variables is presented. We show that the BC-chain method requires onlyO(n) space for the translation. The basic idea is to group together into a single entity a sequence of combinatorsB, B′, C andC′, for a variable, which appear consecutively along a path in the combinator graph. We formulate two reduction algorithms in the new representation. The first algorithm naively simulates the original normal order reduction, while the second algorithm simulates it in constant time per unit operation of the original reduction. Another reduction method is also suggested, and a technique for practical implementation is briefly mentioned.