Cloning of human cDNA encoding a novel heptahelix receptor expressed in Burkitt's lymphoma and widely distributed in brain and peripheral tissues

Using PCR with degenerate primers and screening of a human B-cell lymphoblast cDNA library, a full-length cDNA encoding a 375-amino-acid protein was isolated. It contains seven regions of hydrophobic amino acids probably representing membrane-spanning domains of a novel heptahelix receptor, tentatively named CMKRL2. It shows nearly 30% overall identity with the high-affinity IL8 receptor and similar degree of homology with other chemoattractant receptors, including the "fusin" coreceptors for HIV1. Measurements of various transduction pathways following application of a panel of chemokines to transfected cells failed to evoke any reproducible response. Although the natural ligand for CMKRL2 could, thus, not be identified, receptor expression in spleen and lymph nodes as well as in Burkitt's lymphoma (irrespective of EBV status) supports a functional role in activated B-cells. Receptor message was ubiquitously distributed in normal peripheral tissues and CNS, suggesting that CMKRL2 is expressed in widespread cell populations, such as macrophages and neuroglia.     

A new heuristic to solve the one-warehouse N-retailer problem

We deal with a multi-echelon inventory system in which one warehouse supplies an item to multiple retailers. Customer demand arrives at each retailer at a constant rate. The retailers replenish their inventories from the warehouse that in turn orders from an outside supplier. It is assumed that shortages are not allowed and lead times are negligible. The goal is to determine replenishment policies that minimize the overall cost in the system. We develop a heuristic to compute efficient policies, which also can easily be used in a spreadsheet application. The main idea consists of finding a balance between the replenishment and the inventory holding costs at each installation. This new heuristic we compare with two other approaches proposed in the literature; the computational studies show that in most of the instances generated the new method provides lower costs.     

A framework for developing measurement systems and its industrial evaluation

As in every engineering discipline, metrics play an important role in software development, with the difference that almost all software projects need the customization of metrics used. In other engineering disciplines, the notion of a measurement system (i.e. a tool used to collect, calculate, and report quantitative data) is well known and defined, whereas it is not as widely used in software engineering. In this paper we present a framework for developing custom measurement systems and its industrial evaluation in a software development unit within Ericsson. The results include the framework for designing measurement systems and its evaluation in real life projects at the company. The results show that with the help of ISO/IEC standards, measurement systems can be effectively used in software industry and that the presented framework improves the way of working with metrics. This paper contributes with the presentation of how automation of metrics collection and processing can be successfully introduced into a large organization and shows the benefits of it: increased efficiency of metrics collection, increased adoption of metrics in the organization, independence from individuals and standardized nomenclature for metrics in the organization.     

Design patterns for user interface for mobile applications

The topic of this paper is a collection of user interface (UI) design patterns for mobile applications. In the paper we present the structure of the patterns collection – the patterns are suggested solutions to problems that are grouped into a set of problem areas that are further grouped into three main problem areas – a structure which is valuable both as an index to identifying patterns to use, and it gives a fairly comprehensive overview of issues when designing user interfaces for mobile applications. To show the breadth of the patterns collection we present six individual problems with connected design patterns in some detail – each coming from different problem areas. They represent important and relevant problems, and are on different levels of abstraction, thus showing how patterns may be used to present problems and solutions on different levels of detail. To show the relevance and usefulness of the patterns collection for usability professionals with a mixed background, we present some relevant findings from a validation of the patterns collection. In addition to verifying the relevance and usefulness of the patterns collection, it also shows both expected and surprising correlations between background and perceived relevance and usefulness. One important finding from the validation is an indication that the patterns collection is best suited for experienced UI developers wanting to start developing mobile UIs. Using a patterns collection for documenting design knowledge and experience has been a mixed experience, so we discuss pros and cons of this. Finally, we present related work and future research.     

Competitive exploration of rectilinear polygons

Exploring a polygon with robots when the robots do not have knowledge of the surroundings can be viewed as an online problem. Typical for online problems is that decisions must be made based on past events without complete information about the future. In our case the robots do not have complete information about the environment. Competitive analysis can be used to measure the performance of methods solving online problems. The competitive ratio of such a method is the ratio between the method's performance and the performance of the best method having full knowledge of the future. We prove constant competitive strategies and lower bounds for exploring a simple rectilinear polygon in the _L1$L_1$ metric.     

Stability, Growth, and Decline in Adult Life Span Development of Declarative Memory: Cross-Sectional and Longitudinal Data From a Population-Based Study.

Five-year changes in episodic and semantic memory were examined in a sample of 829 participants (35-80 years). A cohort-matched sample (N=967) was assessed to control for practice effects. For episodic memory, cross-sectional analyses indicated gradual age-related decrements, whereas the longitudinal data revealed no decrements before age 60, even when practice effects were adjusted for. Longitudinally, semantic memory showed minor increments until age 55, with smaller decrements in old age as compared with episodic memory. Cohort differences in educational attainment appear to account for the discrepancies between cross-sectional and longitudinal data. Collectively, the results show that age trajectories for episodic and semantic memory differ and underscore the need to control for cohort and retest effects in cross-sectional and longitudinal studies, respectively. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Electrical, microstructural, physical and chemical characterization of HV XLPE cable peelings for an electrical aging diagnostic data base

The aim of the European project "ARTEMIS" is to develop a diagnostic system for assessing aging in power cable insulation. Its first task was to make a thorough characterisation of the cable insulation before aging. This is intended to provide a background against which any changes introduced by thermo-electric aging can be identified. The aging markers derived from this initial characterisation will be considered both as diagnostic indicators in their own right, and also to develop an aging model for predictive purposes, if and when possible. This stage of the ARTEMIS programme is now complete and we will present an analysis of the results, and show how they may be correlated with the concepts proposed in aging theories.     

Open Embedded Control

Embedded control devices today usually allow parameter changes, and possibly activation of different pre-implemented algorithms. Full reprogramming using the complete source code is not allowed for safety, efficiency, and proprietary reasons. For these reasons, embedded regulators are quite rigid and closed concerning the control structure. In several applications, like industrial robots, there is a need to tailor the low level control to meet specific application demands. In order to meet the efficiency and safety demands, a way of building more generic and open regulators has been developed. The key idea is to use pieces of compiled executable code as functional operators, which in the simplest case may appear as ordinary control parameters. In an object oriented framework, this means that new methods can be added to controller objects after implementation of the basic control, even at run-time. The implementation was carried out in industrially well accepted languages such as C and C++. The dynamic binding at run-time differs from ordinary dynamic linking in that only a subset of the symbols can be used. This subset is defined by the fixed part of the system. The safety demands can therefore still be fulfilled. Encouraged by results from fully implemented test cases, we believe that extensive use of this concept will admit more open, still efficient, embedded systems.     

Finite element simulation of the manufacturing process chain of a sheet metal assembly

An increasing number of components in automotive structures are today made from advanced high strength steel (AHSS). Since AHSS demonstrates more severe springback behaviour than ordinary mild steels, it requires more efforts to meet the design specification of the stamped parts. Consequently, the physical fine tuning of the die design and the stamping process can be time consuming. The trial-and-error development process may be shortened by replacing most of the physical try-outs with finite element (FE) simulations of the forming process, including the springback behaviour. Still it can be hard to identify when a stamped part will lead to an acceptable assembly with respect to the geometry and the residual stress state. In part since the assembling process itself will distort the components. To resolve this matter it is here proposed to extend the FE-simulation of the stamping process, to also include the first level sub-assembly stage. In this study a methodology of sequentially simulating each step in the manufacturing process of an assembly is proposed. Each step of the proposed methodology is described, and a validation of the prediction capabilities is performed by comparing with a physically manufactured assembly. The assembly is composed of three sheet metal components made from DP600 steel which are joined by spot welding. The components are designed to exhibit severe springback behaviour in order to put both the forming and subsequent assembling simulations to the test. The work presented here demonstrates that by using virtual prototyping it is possible to predict the final shape of an assembled structure.