On the Merits of Clinical Judgment: Comment.

Comments on the article by D. Westen and J. Weinberger (see record 2004-19091-002), which criticized academic clinical psychologists for being cynical about clinical judgment and clinical practice. In our view, it seems unlikely that more than a few academic clinical psychologists believe that they have little to learn from clinical practice or experience. In this comment, we examine the arguments about clinical judgment made by Westen and Weinberger (2004). Westen and Weinberger (2004) conflate the effect of training with the effect of experience. Westen and Weinberger (2004) do not mention that the value of training in psychology has been well-supported by research. While Westen and Weinberger (2004) make positive comments about the types of feedback that clinicians receive, for a number of reasons, including the Barnum effect, psychologists can be misled by feedback. Westen and Weinberger (2004) also argue that "psychotherapists tend to have much more direct and immediate feedback than most other medical practitioners, who may prescribe a medication or perform a procedure and not see the patient again for a year" (p. 603). But when psychologists make a diagnosis or describe a personality trait, they frequently do not receive "direct and immediate feedback" on whether they are right or wrong. In contrast, physicians often receive highly valid feedback. Finally, in discussing the value of ratings made by clinicians, Westen and Weinberger (2004) observe that "empirically, we have found surprisingly little evidence of theory-driven observational bias in using clinician-report methods" (p. 601). The issue is important because Westen and Weinberger argue in favor of using clinician ratings to construct diagnostic criteria. If clinicians' ratings are biased, then the criteria will be biased. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

An exploration of the base rate scores of the Millon Clinical Multiaxial Inventory–III.

The Millon Clinical Multiaxial Inventory (3rd ed.; MCMI–III) is a widely used psychological assessment of clinical and personality disorders. Unlike typical tests, the MCMI–III uses a base-rate score transformation to incorporate prior probabilities of disorder (i.e., base rates) in test output and diagnostic thresholds. The authors describe the base rate transformation and contend that its supporting documentation in the MCMI–III manual is incomplete and fails to meet interdisciplinary test documentation standards. They show that the MCMI–III's base rate transformation is not optimal, and they derive an optimal alternative transformation using Bayes' theorem. Bayes transformation formulae for 7 exponential family distributions are given. The authors discuss the effect of the base rate transformation and further argue that the MCMI–III's use of a single base rate per diagnostic category is ill-advised. They argue that base rates differ among clinical settings and that tests like the MCMI–III should flexibly incorporate a base rate of disorder pertinent to the examinee's characteristics, such as demographics, chief complaint, clinical history, or other variables. They explain how this can readily be accomplished. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Sunscreens prevent sunburn cell formation in human skin

Sunscreens with different sun protection factors were examined for their ability to prevent sunburn cell formation in human skin exposed to ultraviolet radiation from a xenon solar simulator. There was either complete or partial protection against the cytotoxic effects of ultraviolet radiation. Protection was related to the sun protection factor of the sunscreen and to the dose of radiation administered.     

Response of the GLAST LAT calorimeter to relativistic heavy ions

The CsI calorimeter of the Gamma-Ray Large-Area Space Telescope (GLAST) will be calibrated in flight with cosmic-ray heavy ions. In order to determine the response of the calorimeter to relativistic heavy ions lighter than Fe, an experiment was carried out at the GSI heavy ion facility using the Fragment Separator (FRS). The measured response exhibits an unexpected feature for light ions, opposite to that observed at low incident energy: for a given deposited energy, the observed signal is greater for these ions than for protons (or more generally Z=1 minimum ionizing particles). Pulse shapes are found to be almost identical for carbon ions and Z=1 particles, with a significant slow scintillation component, which constitutes another departure from the low-energy behavior. Data on the energy resolution for the individual CsI crystals and on the loss of ions due to nuclear reactions in the calorimeter are also presented.     

Toward a resolution of the Rorschach controversy.

Comments are made about the articles comprising the first round of the Special Series on the Rorschach. G. Stricker and J. R. Gold (see record 1999-11130-002) and D. J. Viglione (see record 199911130-003) praised the Rorschach, but they consistently failed to cite negative findings. R. M. Dawes (see record 1999-11130-006) obtained results that provide modest support for the Rorschach, but one of his data sets is flawed. J. B. Hiller et al (see record 1999-11130-005) reported the results of a meta-analysis, but, among other problems, their coders were not blind to the results of all the studies. J. Hunsley and J. M. Bailey (see record 1999-11130-004) made a strong case for concluding that there is no scientific basis for using the Rorschach. Recommendations are made for resolving the Rorschach controversy. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Contour entropy: A new determinant of perceiving ground or a hole.

Figure-ground perception is typically described as seeing one surface occluding another. Figure properties, not ground properties, are considered the significant factors. In scenes, however, a near surface will often occlude multiple contours and surfaces, often at different depths, producing alignments that are improbable except under conditions of occlusion. We thus hypothesized that unrelated (high entropy) lines would tend to appear as ground in a figure-ground paradigm more often than similarly aligned ordered (low entropy) lines. We further hypothesized that for lines spanning a closed area, high line entropy should increase the hole-like appearance of that area. These predictions were confirmed in three experiments. The probability that patterned rectangles were seen as ground when alternated with blank rectangles increased with pattern entropy. A single rectangular shape appeared more hole-like when the entropy of the enclosed contours increased. Furthermore, these same contours, with the outline shape removed, gave rise to bounding illusory contours whose strength increased with contour entropy. We conclude that figure-ground and hole perception can be determined by properties of ground in the absence of any figural shape, or surround, factors. (PsycINFO Database Record (c) 2011 APA, all rights reserved)     

Meehl's contribution to clinical versus statistical prediction.

Paul E. Meehl's work on the clinical versus statistical prediction controversy is reviewed. His contributions included the following: putting the controversy center stage in applied psychology; clarifying concepts underpinning the debate (especially his crucial distinction between ways of gathering data and ways of combining them) as well as establishing that the controversy was real and not concocted, analyzing clinical inference from both theoretical and probabilistic points of view, and reviewing studies that compared the accuracy of these 2 methods of data combination. Meehl's (1954/1996) conclusion that statistical prediction consistently outperforms clinical judgment has stood up extremely well for half a century. His conceptual analyses have not been significantly improved since he published them in the 1950s and 1960s. His work in this area contains several citation classics, which are part of the working knowledge of all competent applied psychologists today. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Differential apoptotic behaviors of c-myc, N-myc, and L-myc oncoproteins

c-, N-, and L-myc are related nuclear oncoproteins that bind similar DNA sites and cooperate with activated ras oncogenes to transform primary fibroblasts. Although c-myc can also promote apoptosis in some cells after growth factor withdrawal or exposure to cytotoxic agents, roles for N- and L-myc in apoptosis remain undetermined. To address this, c-, N-, or L-myc were stably expressed in the interleukin 3 (IL-3)-dependent 32D hematopoietic cell line. The apoptotic response of each cell line was assessed after IL-3 withdrawal or treatment with four structurally unrelated cytotoxic agents. All three oncoproteins accelerated apoptosis after IL-3 withdrawal. In contrast, whereas c-myc overexpression generally sensitized cells to cytotoxic drugs, N-myc and L-myc overexpression produced resistance. myc expression tended to be associated with a more robust G2-M arrest after drug exposure, but this did not correlate with drug sensitivity or resistance. Bcl-2 and Bcl-X(L) protected control cells against apoptosis after either IL-3 withdrawal or drug exposure, although in some cases this effect could be overridden by myc oncoproteins, particularly N-myc and L-myc. Our results suggest that the apoptotic pathways activated upon IL-3 withdrawal and cytotoxic drug treatment are distinct and differentially affected by members of the myc and Bcl-2 families.