Iron complexation to carboxyl groups in a bovine serum albumin digest

Protein is known to aid iron absorption from foods. The possible complexation occurring between iron and an in-vitro protein digest was studied by pH titration and by measuring the concentration of sulphydryl, amino and carboxyl groups in the presence and absence of ferrous and ferric iron. Complexation of iron was shown to occur with the protein digestion products and the carboxyl groups were identified as a site of complexation.     

In-vitro availability of starch in cereal products

The in-vitro availability of starch in Heudebert breads and Lu biscuits was assessed. Starch digestibility increased in the order semi-sweet biscuits, muesli, wholemeal breads, white breads, French toast, extruded crispbread. The results confirm that manufacturing conditions play a determinant role in starch availability in vitro.     

Plasticizing effect of ibuprofen induced an alteration of drug released from Kollidon SR matrices produced by direct compression

The objectives of this study were to investigate the effect of storage temperature on drug release from matrices containing 10, 40 and 70% w/w ibuprofen in Kollidon® SR (KSR). The matrix tablets were produced by direct compression and then kept at 30 and 45?°C for 3 months. Drug release from the matrix tablets was examined after storage for 0, 1, 4 and 12 weeks. Scanning electron microscope was used to reveal physical appearance of the tablet surface at the respective time intervals. In addition, differential scanning calorimeter was used to investigate glass transition temperature (T_g) of ibuprofen in KSR at 0–100% w/w based on the principle of Gordon–Taylor equation. At 45?°C, the dissolution of ibuprofen in KSR as well as the coalescence of polymer particles were observed to be higher than those of storage at 30?°C. The physical state of ibuprofen dispersed in the polymeric matrix and degree of polymer coalescence led to the variation of drug release. The coalescence of polymer particles was a result of the polymer transition from glassy to rubbery state according to water absorption of KSR and plasticizing effect of ibuprofen. The reduction of the T_g of ibuprofen blended with KSR could be better described by the Kwei equation, a modified version of Gordon–Taylor equation.     

应用于化妆品的水杨酸微胶囊载体系统的制备及表征

以阿拉伯胶和麦芽糊精为微胶囊壁材,采用喷雾干燥法制备水杨酸微胶囊,并用傅里叶红外光谱及扫描电子显微镜对包埋行为进行鉴定,还研究了最佳阿拉伯胶／麦芽糊精比、微胶囊溶解度、释放机制及体外透皮性,实验结果表明,最佳阿拉伯胶／麦芽糊精比为1：1,微胶囊化后水杨酸溶解度能够提高至26mg/mL。水杨酸微胶囊呈现球状结构,并具有一定的缓释性,体外透皮结果显示微胶囊化后水杨酸透皮速率减慢并且无突释现象,与未包埋水杨酸相比,水杨酸微胶囊具有更高的皮表保留量和较低的皮肤驻留量。     

Nutritional and anti-nutritional characteristics of mucuna (Mucuna utilis) bean seeds

Some nutritional and anti-nutritional characteristics of mucuna (Mucuna utilis (Wight) Burck) bean seeds were studied. The mature seeds contained 264 g crude protein, 63 g crude fibre, 41 g crude fat, 37 g ash and 595 g carbohydrates kg^?1 DM. The essential amino acid profile compared well with the FAO/WHO scoring pattern except for a deficiency of sulphur-containing amino acids. Mineral composition was similar to those reported for most tropical grain legumes. Raw mucuna seed samples contained moderately high levels of anti-tryptic activity (2170 trypsin units inhibited g^?1 DM), but this was completely destroyed by cooking. The other anti-nutritional factors (phytate, cyanide and tannins) are probably of little nutritional significance provided that the beans are properly processed. The in-vitro protein digestibility of raw and cooked beans were 71·5 and 80·3 %, respectively. In view of the high L-DOPA contents reported in some mucuna cultivars, overconsumption of mucuna beans should be viewed with some caution until suitable processing methods are developed.