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91.
Rachana R. Borkute Sren Woelke Gang Pei Anca Dorhoi 《International journal of molecular sciences》2021,22(9)
Neutrophils readily infiltrate infection foci, phagocytose and usually destroy microbes. In tuberculosis (TB), a chronic pulmonary infection caused by Mycobacterium tuberculosis (Mtb), neutrophils harbor bacilli, are abundant in tissue lesions, and their abundances in blood correlate with poor disease outcomes in patients. The biology of these innate immune cells in TB is complex. Neutrophils have been assigned host-beneficial as well as deleterious roles. The short lifespan of neutrophils purified from blood poses challenges to cell biology studies, leaving intracellular biological processes and the precise consequences of Mtb–neutrophil interactions ill-defined. The phenotypic heterogeneity of neutrophils, and their propensity to engage in cellular cross-talk and to exert various functions during homeostasis and disease, have recently been reported, and such observations are newly emerging in TB. Here, we review the interactions of neutrophils with Mtb, including subcellular events and cell fate upon infection, and summarize the cross-talks between neutrophils and lung-residing and -recruited cells. We highlight the roles of neutrophils in TB pathophysiology, discussing recent findings from distinct models of pulmonary TB, and emphasize technical advances that could facilitate the discovery of novel neutrophil-related disease mechanisms and enrich our knowledge of TB pathogenesis. 相似文献
92.
MSc. Jessica A. I. Muller Dr. Nicole Lawrence Dr. Lai Yue Chan Dr. Peta J. Harvey Dr. Alysha G. Elliott Assoc. Prof. Mark A. T. Blaskovich Dr. Jacqueline C. Gonçalves Dr. Priscilla Galante Dr. Marcia R. Mortari Dr. Mônica C. Toffoli-Kadri Dr. Johannes Koehbach Prof. David J. Craik 《Chembiochem : a European journal of chemical biology》2021,22(8):1415-1423
Agelaia-MPI and protonectin are antimicrobial peptides isolated from the wasp Parachartergus fraternus that show antimicrobial and neuroactive activities. Previously, two analogues of these peptides, neuroVAL and protonectin-F, were designed to reduce nonspecific toxicity and improve potency. Here, the three-dimensional structures of neuroVAL, protonectin and protonectin-F were determined by using circular dichroism and NMR spectroscopy. Antibacterial, antifungal, cytotoxic and hemolytic activities were tested for the parent peptides and analogues. All peptides showed moderate antimicrobial activity against Gram-positive bacteria, with agelaia-MPI being the most active. Protonectin and protonectin-F were found to be toxic to cancerous and noncancerous cell lines. Internalization experiments revealed that these peptides accumulate inside both cell types. By contrast, neuroVAL was nontoxic to all tested cells and was able to enter cells without accumulating. In summary, neuroVAL has potential as a nontoxic cell-penetrating peptide, while protonectin-F needs further modification to realize its potential as an antitumor peptide. 相似文献
93.
Multidimensional Systems and Signal Processing - In medical Image processing, the chief objective is to detect Neoplasm effectively. Neoplasm is basically a sort of abnormal excessive cell growth... 相似文献
94.
Russian Engineering Research - Practical approaches are described for introducing an energy management system at a high-tech enterprise so as to centralize and automate the regulation of energy... 相似文献
95.
M.R. Fatahi 《Canadian Metallurgical Quarterly》2019,58(2):140-155
Enhanced gravity concentrators such as Knelson concentrator (KC) are extensively used in the mineral processing industry. The complexities of KC bowl geometry and variation of feed characteristics have forced process engineers to design empirically new units using laboratory and pilot-scale Knelson concentrators. However, numerical modelling methods such as computational fluid dynamics (CFD) and discrete element method (DEM) provide a better insight of flow behaviour of fluid and particulate solid phases inside these processing units. This article reports findings of CFD simulations for single-phase water flow inside the laboratory KC. An available standard 7.5-cm laboratory KC bowl was numerically simulated using realisable k-ε turbulence model to resolve the turbulence dispersion of existing transitional flow regime. The effects of relative centrifugal force (RCF) intensity and bed fluidisation water flow rate on the water velocity and pressure distributions were studied. Simulations confirmed the swirling flow pattern governing inside the bowl. The results revealed that the impact of RCF intensity on the water field values is greater than that of bed fluidisation water flow rate. Both velocity and pressure variations inside the bowl rings followed a linear trend. 相似文献
96.
Kulikov V. Yu. Aubakirov D. R. Kvon S. S. Dostaeva A. M. Shcherbakova E. P. 《Metallurgist》2019,62(9-10):1068-1072
Metallurgist - We provide an overview of requirements for wear-resistant materials in the Kazakhstani ore mining and smelting industry, and describe the basic variety of metallurgical parts and... 相似文献
97.
Garrido Juan E. Penichet Victor M. R. Lozano Maria Dolores Plata Alberto Mora Valls Jose A. F. 《Universal Access in the Information Society》2019,18(1):3-16
Universal Access in the Information Society - Movement-based interaction has brought about new possibilities in healthcare environments. Concretely, rehabilitation therapies represent an adequate... 相似文献
98.
A visible-light and infrared video database for performance evaluation of video/image fusion methods
Ellmauthaler Andreas Pagliari Carla L. da Silva Eduardo A. B. Gois Jonathan N. Neves Sergio R. 《Multidimensional Systems and Signal Processing》2019,30(1):119-143
Multidimensional Systems and Signal Processing - In general, the fusion of visible-light and infrared images produces a composite representation where both data are pictured in a single image. The... 相似文献
99.
K.M. Shainy Anupama R. Prasad Asha Thomas Abraham Joseph 《Egyptian Journal of Petroleum》2019,28(1):35-45
The synergistic interactions and corrosion protection properties of 2-amino 4-methyl benzothiazole, (AMBT) and 1, 2, 3-benzotriazole (BTZ) have been studied for mild steel in HCl at elevated temperatures. The extent of synergistic interaction increases with temperature. The methods of study include the conventional weight loss studies, computational screening, surface characterization and electrochemical studies. Quantum chemical approach was used to calculate some electronic properties of the molecules and to ascertain the synergistic interaction, inhibitive effect and molecular structures. The corrosion inhibition efficiencies and the global chemical reactivity relate to parameters like total energy, EHOMO, ELUMO and gap energy (ΔE). Condensed atom Fukui functions also calculated using DFT at B3LYP/6-31G* level, and were found to be correlating with the experimental results. 相似文献
100.