焊后低温热处理对马氏体不锈钢组织和性能的影响

对ZG06Cr13Ni4Mo马氏体不锈钢进行了焊后低温热处理工艺试验(240、300 ℃),通过显微组织分析、拉伸及弯曲试验、硬度试验及残余应力测试对不同低温热处理下焊接接头的显微组织、力学性能、硬度和残余应力等进行了研究。结果表明,经低温热处理后,接头焊缝热影响区组织为回火马氏体及碳化物,接头焊缝区的组织为低碳马氏体+块状马氏体+碳化物,接头的抗拉强度变化不大,硬度略有下降,经240 ℃低温热处理后,焊接接头焊缝处的残余应力消除了69.1%。     

间隙配合变轨距轮对与轨道间瞬态滚滑接触模拟研究

变轨距技术是实现不同轨距铁路联运的重要手段，我国相关研究仍在起步阶段。基于显式有限元法，建立包含渐开线花键副的三维变轨距轮对-轨道耦合瞬态分析模型，于时域内模拟速度高至400 km/h下的瞬态轮轨滚滑和花键间动态接触行为及其相互影响。模型充分考虑轮轨和花键副三维几何、系统高频结构振动等，引入时变牵引/制动转矩，采用集成库仑摩擦定律的"面-面"接触算法求解轮轨接触和花键接触。假设圆柱直齿渐开线花键，齿数取32，齿侧间隙恒0.1 mm，无激励下模拟结果表明，花键副的存在使得轮轨力波动范围大于传统轮对，例如，400 km/h下法向轮轨力波动幅值增加静载的3.7%。时速400 km/h和牵引系数0.05下，内外花键的径向和角向偏置使得花键左、右两侧各存在1个位置相对固定的承载区，各涉及5~6个键齿，承载面分别为II和I键齿工作面。瞬态法、切向接触应力极值发生在靠近一系悬挂侧的齿根或齿顶部，典型值分别为102 MPa和4.6 MPa，任一键齿的应力极值因不断有键齿进出承载区而波动上升和下降。牵引系数0.3时，左侧承载区消失，右侧承载区扩至18个键齿，相同时刻下的法、切向接触应力极值因承载齿数和总接触面积增加变为89 MPa和5.2 MPa。为变轨距机构中花键的强度和动力学分析及相关设计提供精确模拟手段。     

砂砾石地基上水闸闸墩下局部灌浆效果及合理范围分析

水闸通常需要进行地基处理,以降低差异沉降和底板应力。根据水闸荷载集中在闸墩上的特点,提出了一种在闸墩下的砂砾石地基局部灌浆的处理方式。结合工程实例,通过有限元软件ABAQUS计算和比较地基局部灌浆前后闸底板的应力,该地基处理方式降低了底板应力。比较不同灌浆范围时闸底板的最大拉应力,发现当地基局部灌浆区域总宽度与闸室宽度的比值约为35%时,闸底板最大拉应力的降幅效果最好。     

Optimized etching of porcelain and polycrystalline alumina with a glass phase

Chemical and thermal etching techniques are commonly used in ceramography to enhance microstructural features. While thermal etching works well for high purity ceramic systems, this technique may not be appropriate where glass is present. Porcelain and industrial alumina both contain a glass phase, typically 40?60 vol% and 4?30 vol%, respectively, and these glass chemistries are proposed to be similar. Chemical etching of porcelain is common, but the images published in the literature are frequently over-etched. When glass is present in the grain boundaries of alumina, thermal etching can cause the glass to disappear or to recrystallize, obscuring the microstructure. Because of this, it is proposed that both chemical and thermal etching are necessary to prepare an industrial alumina microstructure for grain size measurements. In addition, it was observed that chemical etching is sensitive to the residual stress in the glass phase, becoming more aggressive when there is residual tension in the glass.     

Investigation of thermal residual stresses during laser ablation of tantalum carbide coated graphite substrates using micro-Raman spectroscopy and COMSOL multiphysics

Laser ablation of high-temperature ceramic coatings results in thermal residual stresses due to which the coatings fail by cracking and debonding. Hence, the measurement of such residual stresses during laser ablation process holds utmost importance from the view of performance of coatings in extreme conditions. The present research aims at investigating the effect of laser parameters such as laser pulse energy, scanning speed and line spacing on thermal residual stresses induced in tantalum carbide-coated graphite substrates. Residual stresses were measured using micro-Raman spectroscopy and correlated with Raman peak shifts. Transient thermal analysis was performed using COMSOL Multiphysics to model the single ablated track and residual stresses were reported at low, moderate and high pulse energy regimes. The results showed that the initial laser conditions caused higher tensile residual stresses. Moderate pulse energy regime comprised higher compressive residual stresses due to off centre overlapping of the laser pulses. Higher pulse energy (250 μJ), higher scanning speed (1000 mm/s) and moderate line spacing (20 μm) caused accumulation of tensile residual stresses during the final stage of laser ablation. The deviation of experimental residual stresses from COMSOL numerical model was attributed to unaccounted additional stresses induced during thermal spraying process and deformation potentials in the numerical model.     

Pleiotropic Effects of Sodium-Glucose Cotransporter-2 Inhibitors: Renoprotective Mechanisms beyond Glycemic Control

Diabetes mellitus is a major cause of chronic kidney disease and end-stage renal disease. However, the management of chronic kidney disease, particularly diabetes, requires vast improvements. Recently, sodium-glucose cotransporter-2 (SGLT2) inhibitors, originally developed for the treatment of diabetes, have been shown to protect against kidney injury via glycemic control, as well as various other mechanisms, including blood pressure and hemodynamic regulation, protection from lipotoxicity, and uric acid control. As such, regulation of these mechanisms is recommended as an effective multidisciplinary approach for the treatment of diabetic patients with kidney disease. Thus, SGLT2 inhibitors are expected to become key drugs for treating diabetic kidney disease. This review summarizes the recent clinical evidence pertaining to SGLT2 inhibitors as well as the mechanisms underlying their renoprotective effects. Hence, the information contained herein will advance the current understanding regarding the pleiotropic effects of SGLT2 inhibitors, while promoting future research in the field.     

Translesion Synthesis or Repair by Specialized DNA Polymerases Limits Excessive Genomic Instability upon Replication Stress

DNA can experience “replication stress”, an important source of genome instability, induced by various external or endogenous impediments that slow down or stall DNA synthesis. While genome instability is largely documented to favor both tumor formation and heterogeneity, as well as drug resistance, conversely, excessive instability appears to suppress tumorigenesis and is associated with improved prognosis. These findings support the view that karyotypic diversity, necessary to adapt to selective pressures, may be limited in tumors so as to reduce the risk of excessive instability. This review aims to highlight the contribution of specialized DNA polymerases in limiting extreme genetic instability by allowing DNA replication to occur even in the presence of DNA damage, to either avoid broken forks or favor their repair after collapse. These mechanisms and their key regulators Rad18 and Polθ not only offer diversity and evolutionary advantage by increasing mutagenic events, but also provide cancer cells with a way to escape anti-cancer therapies that target replication forks.     

Some Molecular and Cellular Stress Mechanisms Associated with Neurodegenerative Diseases and Atherosclerosis

Chronic stress is a combination of nonspecific adaptive reactions of the body to the influence of various adverse stress factors which disrupt its homeostasis, and it is also a corresponding state of the organism’s nervous system (or the body in general). We hypothesized that chronic stress may be one of the causes occurence of several molecular and cellular types of stress. We analyzed literary sources and considered most of these types of stress in our review article. We examined genes and mutations of nuclear and mitochondrial genomes and also molecular variants which lead to various types of stress. The end result of chronic stress can be metabolic disturbance in humans and animals, leading to accumulation of reactive oxygen species (ROS), oxidative stress, energy deficiency in cells (due to a decrease in ATP synthesis) and mitochondrial dysfunction. These changes can last for the lifetime and lead to severe pathologies, including neurodegenerative diseases and atherosclerosis. The analysis of literature allowed us to conclude that under the influence of chronic stress, metabolism in the human body can be disrupted, mutations of the mitochondrial and nuclear genome and dysfunction of cells and their compartments can occur. As a result of these processes, oxidative, genotoxic, and cellular stress can occur. Therefore, chronic stress can be one of the causes forthe occurrence and development of neurodegenerative diseases and atherosclerosis. In particular, chronic stress can play a large role in the occurrence and development of oxidative, genotoxic, and cellular types of stress.     

水平井分段体积压裂复杂裂缝形成机制研究现状与发展趋势

水平井分段体积压裂是油气储层中复杂裂缝网络形成的重要技术之一，准确了解复杂裂缝网络形成机制、预测复杂裂缝网络形态对非常规油气资源高效开发具有重要意义，同时也是水力压裂设计优化的理论基础。围绕非常规储层复杂裂缝形成机制，国内外学者根据"应力阴影"效应对水力裂缝同步扩展、水力压裂顺序对多裂缝动态延伸影响、层理面对水力裂缝纵向扩展遮挡效应和天然裂缝与水力裂缝交互动态等方面，分别建立了相应的水力压裂模型，并从数值模拟角度对其进行了定性分析。通过总结国内外研究现状，并从模型建立假设条件、数值模拟模型思想和模型局限性3方面对现有模型进行了剖析，并对未来研究方向提出了建议，研究结果可对未来水力压裂复杂裂缝形成机制研究提供借鉴。