Study of physicochemical properties of flutamide-loaded Ocimum basilicum microspheres with ex vivo mucoadhesion and in vitro drug release

Drug which shows extensive first pass effect is difficult task that, needs to be solved by formulators in the pharmaceutical science. The low oral bioavailability (49%) of flutamide may be due to poor wettability, low aqueous solubility and extensive first pass effect. The aim of present investigation was to prepare flutamide loaded microspheres and incorporate it into suppositories for rectal delivery to avoid first pass effect and enhance residence time. Flutamide loaded mucoadhesive microspheres of Ocimum Basilicum mucilage (OBM) were prepared using spray drying and characterized by percent production yield, encapsulation efficiency, particle size, zeta potential, polydispersity index, DSC, SEM, XRPD, in vitro drug release and stability studies. Moreover, ex vivo mucoadhesion was investigated using falling liquid film technique to determine the adhesion of microspheres to sheep rectal mucosa. The microspheres had nearly spherical shape and size about 2.53?μm. The encapsulation efficiency and mucoadhesion of optimized formulation MBF10 were found to be 69.6?±?2.3% and 89.01?±?2.18%, respectively. Percent CDR of optimized flutamide loaded mucoadhesive microspheres was found to be 88.7?±?1.3 at 7?h. In conclusion, OBM microparticles based suppository could be used to deliver drug through rectal delivery.     

Measurement of vertical and horizontal vibrations of a probe for acoustic evaluation of food texture

Two‐dimensional (vertical and horizontal) vibrations of a wedge‐type probe upon food rupture were evaluated separately using two accelerometers placed perpendicular to a guide rod of a swing‐arm device for texture evaluation of the flesh of three varieties of apples and three types of potato chips. Voltage signals from the accelerometers were filtered using a half‐octave band‐pass filter. The energy texture index (ETI), based on kinetic energy of the vertical or horizontal probe vibrations, was calculated over low to high frequency bands (no. 1–21). The spectra for the flesh of the three varieties of apples included two common peaks for vertical ETI at band no. 11 (1,120–1,600 Hz) and 19 (17,920–25,600 Hz) and horizontal ETI at band no. 1 (0–10 Hz) and 15 (4,480–6,400 Hz). The spectra for the three types of potato chips had a common ETI peak at band no. 11 (1,120–1,600 Hz) for horizontal ETI and at no. 15 (4,480–6,400 Hz) for vertical ETI. The three apple varieties gave rise to different intensities of vertical and horizontal ETIs while the two peaks were maintained. The thick potato chip type had higher vertical and horizontal ETIs than the thin and soft varieties in most bands; however, the thin type had the highest vertical ETIs only in lower bands (0–200 Hz). The soft type had the lowest vertical and horizontal ETI. The above results suggest that different food textures can be distinguished by two‐dimensional vibration analyses of probe insertion into a food sample based on frequency bands.     

基于凸闭包集的不规则三角网算法研究与实现

不规则三角网是影响土石方量计算的关键问题之一，虽然目前已有大量研究人员对Delaunay三角网进行优化，但仍然缺少对三角网生成速率和计算精度的综合研究。针对此问题，基于VB.NET平台的点、边以及三角形的结构化数据结构设计快速生成凸闭包集形成Delaunay三角网，通过四边形空圆特性以及对角线最短原则对构网结果进行检验和优化。试验计算表明，该算法的计算结果与经典DTM法、方格网法的土方量计算相对误差均在0.30%以内。该方法不仅具有较高的组网效率，并能保持较好的计算精度。     

基于多线结构光的弱纹理物体形貌测量方法

大多数现有的主流结构光测量装置在被测物体的表面上投射单条激光,通过移动装置实现物体表面的扫描重建。为了实现物体表面的在线快速重建,将多线结构光和双目立体视觉理论相结合,设计了一种新的三维测量方法。提出了一种结合形态滤波和Zhang-Suen细化算法的光条骨架提取方法和基于光条序列关系的光条匹配算法,并通过极线约束实现光条上特征点的精确匹配。通过实验验证了方法的有效性,相对误差在3%以内。     

采场顶板关键层"横U-Y"型周期破断特征的试验研究

针对部分坚硬顶板矿井采动导水裂缝带处于8~15倍采高的高位关键层,"横O-X"破断运动引发工作面动载矿压甚至压架、临采空侧回风平巷超前100~200 m底鼓大变形等动力灾害的问题,采用自制的大尺度三维物理模拟实验平台,研究高位关键层的破断运动特征。结果表明:关键层发生横向破断时,首先,关键层板正面两侧长边和反面中部长轴方向同时形成破断裂隙;其次,关键层板正面两侧短边形成弧形裂隙,而反面沿中轴线端点同步形成八字形破断裂隙;再次,在板正面形成"O"形裂隙的同时反面形成"X"形裂隙,正面形成"U"形裂隙的同时反面形成"Y"形裂隙;最后,正反面裂缝贯通形成"横O-X"型初次破断和"横U-Y"型周期破断,在工作面上方形成"弧形三角板"和巷道上方形成"梯形板"的破断块体结构。统计发现,"横O-X"型初次破断步距与"横U-Y"型周期破断步距长度基本一致;横向破断形成的"弧形三角板"块体角度为75°~78°,与腰线和弧形切线形成的夹角72°~82°基本相等,近似于一个等角的"弧形三角板"。砌块模型试验结果表明,"弧形三角板"块体大幅回转过程中,因其顶点易与"梯形板"结构发生回转变形失稳而出现脱离现象,导致"弧形三角板"滑落失稳从而会引发工作面强矿压。研究成果为大采高开采工作面强矿压灾害防治提供试验基础。     

基于普吕克直线的多线结构光视觉传感器标定方法

针对多线结构光系统的快速标定,提出了一种基于普吕克直线的标定方法。传统的线结构光标定方法大多以单点的形式进行提取和坐标系转换,从而获得平面方程。然而单点数量较多会导致操作复杂,不适用于多线结构光的标定。为了解决这个问题,提出了一种新的标定方法,该方法在标定过程中全部采用普吕克矩阵的形式,而不是直接使用点特征。该方法有利于在摄像机坐标系下快速准确地获得光平面方程。同时设计了一种与该方法相对应的用于标定多线结构光的平面标定靶标。为了将一般直线转换为普吕克直线,将图像平面维度延展,定义了一个新的图像空间。为了对普吕克直线的坐标系进行转换,重新表达了基于普吕克直线的透视投影模型。基于普吕克空间中直线与平面的性质,对多条结构光线的普吕克矩阵进行合并即可高效地构造出线性的矩阵方程,从而进一步拟合出结构光平面方程。实验验证了所提方法并证明了校准精度的显著提高,当测试距离为1.8 m时,测量得到的三维点的RMS误差在0.08 mm之内。     

45钢圆钢热顶锻开裂原因分析及改进措施

针对福建省三钢集团有限责任公司棒材厂45钢圆钢热顶锻出现的爆裂、斜向开裂、4角纵向通长开裂、纵向断续微裂4种开裂形式，从表面质量、组织、夹杂物、断口形貌等方面分析了其产生原因。结果表明，钢中存在粗大夹杂物是产生爆裂的主要原因；母材塑性不足是斜向开裂的主要原因；孔型设计不合理带来的皱褶缺陷引起了4角纵向通长开裂；除鳞不净，氧化铁皮压入导致了纵向断续微裂的产生。为此，提出了提高冶炼质量、改进化学成分、调整高压水除鳞工艺、优化孔型设计等措施，显著提高了其热顶锻合格率。     

Mini-MPM连轧管机194 mm系列孔型开发

在现有Mini-MPM连轧管机孔型参数的基础上,按照顶部延伸系数分配法,开发出194 mm系列连轧管机孔型,同时重新设计穿孔机顶头;统计194 mm系列孔型生产Φ139.7 mm×7.72 mm规格石油套管和Φ178mm×9 mm规格车轴管的成材率和壁厚情况。分析认为:设计的194 mm系列孔型是可行的;采用194 mm系列孔型轧制的两个规格产品,其产品质量稳定,且成材率高。     

国家级绿色矿山试点单位成效分析与建议

随着全国绿色矿山名录的公布,国家级绿色矿山试点单位也完成了其历史使命。原有的661家国家级绿色矿山试点单位中有398家通过遴选进入了名录,本文从省份、区域、行业、规模等方面对试点单位通过遴选的情况进行了梳理分析,进而对试点建设工作成效与作用进行了总结,认为经过试点工作树立了大批先进典型模式、探索了矿业转型升级新路径、为全国绿色矿山名录形成奠定了重要基础,并对下一步继续推进绿色矿山建设工作提出了相关建议,认为不同类型矿山企业创建绿色矿山时工作要有所侧重、已纳入名录绿色矿山要持续推进绿色发展避免被除名、管理部门对纳入名录的绿色矿山要加强激励支持与监督管理。