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Scope: An early reaction in osteoarthritic chondrocytes is hyaluronan overproduction followed by proteoglycan loss and collagen degradation. We recently found that hyaluronan is exported by the ATP‐binding cassette transporter multidrug resistance associated protein 5 (MRP5) in competition with cGMP and that some phosphodiesterase 5 inhibitors also inhibited hyaluronan export. These inhibitors also prevented osteoarthritic reactions in cartilage. In an effort to identify the improved inhibitors directed primarily toward MRP5, we analyzed the flavonoids Methods and results: Prenylflavonoids from hop xanthohumol, isoxanthohumol and 8‐prenylnaringenin inhibited MRP5 export at lower concentrations than phosphodiesterase 5 activity. They were analyzed for their effect on IL‐induced osteoarthritic reactions in bovine chondrocytes. Xanthohumol was the superior compound to inhibit hyaluronan export, as well as proteoglycan and collagen loss. It also prevented the shedding of metalloproteases into the culture medium. It directly inhibited MRP5, because it reduced the export of the MRP5 substrate fluorescein immediately and did not influence the hyaluronan synthase activity. Conclusions: Xanthohumol may be a natural compound to prevent hyaluronan overproduction and subsequent reactions in osteoarthritis. 相似文献
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根据生产计划与控制的基本功能要求,分析物料需求计划在不同时期的发展状况,再次强调了MRP的概念,对MRP系统有效运行的进行详细的分析,最终对企业的生产管理和控制提供帮助,提高其竞争力。 相似文献
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MRP系统的设计缺陷改进研究 总被引:4,自引:0,他引:4
从MRP系统内部进行分析,将引起问题的原因归结为MRP在系统设计上的两个缺陷:一是批量计算上的缺陷;二是作业计划上的缺陷。然后采纳其他管理思想和技术(如ABC、JIT、APS等)的可取之处去改进这两个缺陷,以提高国内企业实施MRP的成功率。 相似文献
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针对复杂产品制造企业应用常规MRP算法编制的生产计划存在有效性差、调整频繁、重复计算量大等问题,提出了一种以计划网络为基础的MRP算法.该算法是在常规MRP算法的基础上,将运算产生的多级需求计划指令与生产实际安排建立关联关系,应用网络计划技术构建零组件计划网络,增强和扩展了MRP功能,提高了需求计划指令的有效性,并在原型系统开发中得到可行性验证. 相似文献
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小型制造企业如何改进利用MRP制订采购计划 总被引:1,自引:0,他引:1
傅静芳 《宁波工程学院学报》2008,20(3):9-11
文章主要针对小型生产企业量少类多、计划多变而导致料品采购库存难以控制的特点,提出在传统MRP的基础上,结合甘特图的特点,进行改进并设计表格,以适合小型生产企业。 相似文献
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S. C. L. Koh A. Gunasekaran S. M. Saad 《The International Journal of Advanced Manufacturing Technology》2006,31(3-4):305-315
This research has developed and implemented a part recognition and classification structure to execute parts verification in a multi-level-dependent demand manufacturing system. The part-recognition algorithm enables the parent and child relationship between parts to be recognised in a finite-capacitated manufacturing system. This algorithm was developed using the SIMAN simulation language and implemented in a multi-level-dependent demand manufacturing simulation model. The part-classification structure enables the modelling of a multi-level-dependent demand manufacturing system between parts to be carried out effectively. The part-classification structure was programmed using Visual Basic Application (VBA) and was integrated into the work-to-list generated from a simulated materials requirements planning (MRP) model. This part-classification structure was then implemented in the multi-level-dependent demand manufacturing simulation model. Two stages of implementation, namely, parameterisation and execution, of the part recognition and classification structure were carried out. A real case study was used and five detailed steps of execution were processed. Simulation experiments and MRP were run to verify and validate the part recognition and classification structure. The results led to the conclusion that implementation of the recognition and classification structure has effectively verified the correct parts and sub-assemblies used for the correct product and order. No parts nor sub-assembly shortages were found, and the quantity required was produced. The scheduled release for some orders was delayed due to overload of the required resources. When the loading is normal, all scheduled release timing is adhered to. The recognition and classification structure has a robust design; hence, it can be easily adapted to new system parameters to study different or more complex cases. 相似文献
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基于Internet的虚拟企业资源计划V-ERP 总被引:11,自引:0,他引:11
虚拟企业(VE)是随着Internet而出现的。随着VE的出现,经历了从MRP、MRPⅡ到ERP的发展过程的计划技术必须跟着演进。文章在分析计划技术发展过程的基础上提出了基于Internet的虚拟企业资源计划(V-ERP)。V-ERP是由顾客需求驱动的,它可以集成不同计划方法来制订虚拟企业中所有合作伙伴的计划。文章分析了V-ERP的特点,并讨论了其构成。 相似文献