一类分数阶微积分的中值定理及应用

Riemann-Liouville分数阶微积分算子是一类带有一个函数的分数阶微积分算子的特殊情形，以Riemann-Liouville分数阶微积分算子的积分中值定理和微分中值定理为基础，我们得到了一类带有一个函数的分数阶微积分算子的积分中值定理和微分中值定理，并给出其在计算方面的一些应用。     

What Can We Learn from FGF-2 Isoform-Specific Mouse Mutants? Differential Insights into FGF-2 Physiology In Vivo

Fibroblast growth factor 2 (FGF-2), ubiquitously expressed in humans and mice, is functionally involved in cell growth, migration and maturation in vitro and in vivo. Based on the same mRNA, an 18-kilo Dalton (kDa) FGF-2 isoform named FGF-2 low molecular weight (FGF-2LMW) isoform is translated in humans and rodents. Additionally, two larger isoforms weighing 21 and 22 kDa also exist, summarized as the FGF-2 high molecular weight (FGF-2HMW) isoform. Meanwhile, the human FGF-2HMW comprises a 22, 23, 24 and 34 kDa protein. Independent studies verified a specific intracellular localization, mode of action and tissue-specific spatiotemporal expression of the FGF-2 isoforms, increasing the complexity of their physiological and pathophysiological roles. In order to analyze their spectrum of effects, FGF-2LMW knock out (ko) and FGF-2HMWko mice have been generated, as well as mice specifically overexpressing either FGF-2LMW or FGF-2HMW. So far, the development and functionality of the cardiovascular system, bone formation and regeneration as well as their impact on the central nervous system including disease models of neurodegeneration, have been examined. This review provides a summary of the studies characterizing the in vivo effects modulated by the FGF-2 isoforms and, thus, offers a comprehensive overview of its actions in the aforementioned organ systems.     

自重湿陷性黄土地基预钻孔浸水处理的可靠度设计方法

为解决传统预浸水法存在的浸水时间长、浸水处理范围难以确定等不足,基于土体中水分运移规律,依据可靠度理论、极限状态设计方法及复合 Poisson 过程原理,提出一种消除黄土湿陷性的处理浸水方法——预钻孔浸水法。给出了利用预钻孔浸水法对自重湿陷性黄土地基进行浸水时,水平向及竖直向浸水影响范围的确定模型;在此基础上结合达西定律给出了浸水孔设计参数如孔深、孔间距及浸水孔个数的确定方法。结合铜川某工程,设计进行了现场预钻孔浸水试验,对该方法的合理性进行了验证,并通过现场钻探、现场勘探、室内湿陷性试验等方法对该方法的处理效果进行了评价。该浸水方法具有浸水时间短、浸水影响范围可根据浸水孔布设进行控制等优点,且浸水处理效果良好,完全符合施工要求。     

Autonomic Nervous System in Obesity and Insulin-Resistance—The Complex Interplay between Leptin and Central Nervous System

The role of the autonomic nervous system in obesity and insulin-resistant conditions has been largely explored. However, the exact mechanisms involved in this relation have not been completely elucidated yet, since most of these mechanisms display a bi-directional effect. Insulin-resistance, for instance, can be caused by sympathetic activation, but, in turn, the associated hyperinsulinemia can activate the sympathetic branch of the autonomic nervous system. The picture is made even more complex by the implicated neural, hormonal and nutritional mechanisms. Among them, leptin plays a pivotal role, being involved not only in appetite regulation and glucose homeostasis but also in energy expenditure. The purpose of this review is to offer a comprehensive view of the complex interplay between leptin and the central nervous system, providing further insights on the impact of autonomic nervous system balance on adipose tissue and insulin-resistance. Furthermore, the link between the circadian clock and leptin and its effect on metabolism and energy balance will be evaluated.     

西湖凹陷中部西斜坡地区超压成因机制

沉积盆地超压成因研究已取得了重要进展，关于超压主要成因的认识也发生了重要变化，以往一些被普遍认为属于典型不均衡压实成因的超压已被部分或完全否定，生烃作用作为超压成因的普遍性得到愈来愈多的证实。西湖凹陷多个构造带的不同层位均发育超压，目前认为超压的形成仍然离不开不均衡压实（欠压实作用）的贡献。根据异常压力形成的基本地质条件和异常压力产生的地质、地球物理效应两方面因素，利用测井曲线组合分析法、鲍尔斯法（加载-卸载曲线法）、声波速度-密度交会图法、孔隙度对比法、压力计算反推法以及综合分析法系统解剖分析了西湖凹陷中部西斜坡地区平湖组不同岩性异常压力成因。研究结果表明：西湖凹陷中部西斜坡泥岩中烃源岩超压主要为自源生烃增压，非烃源岩超压为邻源压力传导成因。储层中至少存在常压-超压型和常压-超压-常压型两种压力结构类型，异常压力自南向北顶界面逐渐变深，主要为油气在生烃增压驱动下向储层运移过程中的压力传导所致。     

Visually deficient working conditions and reduced work performance in office workers: Is it mediated by visual discomfort?

IntroductionThe main purpose of this cross-sectional study was to investigate whether visual discomfort acts as a mediating factor between perceived visual ergonomic working conditions and self-rated visual performance among office workers who carry out administrative tasks and computer-based work at the Swedish Tax Agency.MethodsA questionnaire was sent to 94 office workers addressing: 1) perceived visual quality of the visual display units; 2) prevalence of eye symptoms; and 3) self-rated visual performance. Eighty-six persons (54 women (63%), 31 men (36%), and 1 of unspecified sex) answered the questionnaire. Multiple regression analysis investigated the association between visual ergonomic working conditions and visual performance, both with and without visual discomfort as a mediator.ResultsThe group mean of the Indexed survey questions indicated a reasonably good quality of visual ergonomic working conditions, a relative absence of eye symptoms, and acceptable self-rated visual performance. Results from multiple regression analysis showed a significant association between perceived visual ergonomic working conditions and self-rated visual performance (r² = 0.30, β = 0.327, p < 0.01). When visual discomfort was used as a mediator, the association between perceived visual ergonomic working conditions and self-rated visual performance remained the same (r² = 0.32, β = 0.315, p < 0.01).DiscussionIt was remarkable to discover that self-rated visual performance was independent of visual discomfort. Possible explanations include exposure factors not included in the current study, such as dry air and sensory irritation in the eyes, psychosocial stress, time spent performing near work activities, or time exposed to visually deficient working conditions.Relevance to industryThe strong connection between satisfaction with visual ergonomic working conditions and productivity in this study has implications for workplace profitability and staff satisfaction. If productivity is enhanced by better visual ergonomic working conditions, then managers of workplaces may be able to improve work outcomes by optimizing the physical work environment.     

Study of planar structure applying reciprocity technique combined with MGEC and analysis of discontinuity

The 3D structure electromagnetic computation presents several difficulties related to the volume mesh. In fact, the entire volume space must be taken into account even the smallest details. In this article, we propose a formulation based on the reciprocity theorem combined with the generalized equivalent circuit method to model a planar 3D structure with both coaxial and planar excitation. The major advantage of this formulation is the fact to reduce the computational volume into 2D ones in the discontinuity plane. In addition, we focused on the calculation of the discontinuity between the excitation source and the planar structure to determine the exact behavior of the electric coaxial excitation model. The obtained current density, electric field distributions, and the input impedance are presented and discussed in the following sections. An approximately good agreement of input impedance with those obtained by the simulator and measurement is shown.     

Weighted preliminary-summation-based principal component analysis for non-Gaussian processes

For industrial chemical process, preliminary-summation-based principal component analysis (PS-PCA), an amended PCA method was recently provided for coping with both Gaussian and non-Gaussian characteristics. By summing the training and monitoring data respectively, PS-PCA is capable of resolving the issue of non-Gaussian processes and achieves higher fault detection rate than the traditional PCA. However, in the PS-PCA summation operation, all data samples are regarded as the same weight, which results in the fault information of newly-samples may be diluted, leading to significant detection delays. To address this challenge, in this paper, we propose a novel weighted PS-PCA (WPS-PCA) method that employs an exponential weighting scheme to put more emphasis on recent information. Subsequently, a mathematical argument demonstrates that when the number of variables is enough plentiful, the obtained summation combined with the generalized central limit theorem conforms to approximately a Gaussian distribution. The kurtosis relationships indicate this conversion will bring out well-pleasing feasibility for conventional PCA. Ultimately, the proposed technique verifies detection performance using the Tennessee Eastman process, which is compared with the existing PCA and PS-PCA schemes, in terms of the fault detection time and fault detection rate. The simulation studies reveal that the proposed method is efficient and superior.