Acquisition and Spread of Antimicrobial Resistance: A tet(X) Case Study

Understanding the mechanisms leading to the rise and dissemination of antimicrobial resistance (AMR) is crucially important for the preservation of power of antimicrobials and controlling infectious diseases. Measures to monitor and detect AMR, however, have been significantly delayed and introduced much later after the beginning of industrial production and consumption of antimicrobials. However, monitoring and detection of AMR is largely focused on bacterial pathogens, thus missing multiple key events which take place before the emergence and spread of AMR among the pathogens. In this regard, careful analysis of AMR development towards recently introduced antimicrobials may serve as a valuable example for the better understanding of mechanisms driving AMR evolution. Here, the example of evolution of tet(X), which confers resistance to the next-generation tetracyclines, is summarised and discussed. Initial mechanisms of resistance to these antimicrobials among pathogens were mostly via chromosomal mutations leading to the overexpression of efflux pumps. High-level resistance was achieved only after the acquisition of flavin-dependent monooxygenase-encoding genes from the environmental microbiota. These genes confer resistance to all tetracyclines, including the next-generation tetracyclines, and thus were termed tet(X). ISCR2 and IS26, as well as a variety of conjugative and mobilizable plasmids of different incompatibility groups, played an essential role in the acquisition of tet(X) genes from natural reservoirs and in further dissemination among bacterial commensals and pathogens. This process, which took place within the last decade, demonstrates how rapidly AMR evolution may progress, taking away some drugs of last resort from our arsenal.     

电网设备线夹开裂原因

某电力公司变电站用铝合金设备线夹在运行过程发生批次开裂事故,通过宏观观察、断口分析、化学成分分析、力学性能测试、冷冻模拟试验等方法,对设备线夹的开裂原因和开裂机理进行了分析。结果表明:设备线夹焊缝存在焊接缺陷,导致焊缝强度下降;设备线夹接线管底部存在积水空间,寒冷天气下积水结冰,体积膨胀,使焊缝承受设计工况外的负载而过载开裂,造成了线夹开裂。     

5G与WiMAX双模AeroMACS机载终端设计与实现

针对现有航空移动机场通信系统(Aeronautical Mobile Airport Communication System,AeroMACS)尚未形成成熟的机载装机产品的问题,开展AeroMACS机载终端的研究。提出一种基于5G与WiMAX技术的双模AeroMACS机载终端设计方案,不仅能够实现国际标准WiMAX模式下的AeroMACS数据通信,而且利用国内5G技术的优势,大幅提升了AeroMACS机载终端的数据传输性能。通过设计的双通测试与传输速率测试方案,采用灌包测试的方法,验证了所设计的AeroMACS机载终端可以进行双模同时通信的功能,也表明了5G技术下的AeroMACS机载终端传输速率优于WiMAX技术。     

小微数据包高效无线传输技术的发展和趋势

5G-NR和B5G系统都需能高效地支持小微数据包(块)的传输,且在不同的无线传输技术(如宽带或超低时延)之间快速灵活地切换。系统梳理和比较和小微数据包(块)相关的多种无线传输技术,如两步RACH、预配置授权和公共资源竞争等,分析它们对3GPP各个系统和各个RAN协议的影响和复杂度优劣等,并进一步展望其未来发展和应用趋势。     

移动边缘计算环境下的动态资源分配策略

在通讯设备爆炸式增长的时代,移动边缘计算作为5G通讯技术的核心技术之一,对其进行合理的资源分配显得尤为重要。移动边缘计算的思想是把云计算中心下沉到基站部署(边缘云),使云计算中心更加靠近用户,以快速解决计算资源分配问题。但是,相对于大型的云计算中心,边缘云的计算资源有限,传统的虚拟机分配方式不足以灵活应对边缘云的计算资源分配问题。为解决此问题,提出一种根据用户综合需求变化的动态计算资源和频谱分配算法(DRFAA),采用"分治"策略,并将资源模拟成"流体"资源进行分配,以寻求较大的吞吐量和较低的传输时延。实验仿真结果显示,动态计算资源和频谱分配算法可以有效地降低用户与边缘云之间的传输时延,也可以提高边缘云的吞吐量。     

Hierarchical sampling optimization of particle filter for global robot localization in pervasive network environment

This paper presents a hierarchical framework for managing the sampling distribution of a particle filter (PF) that estimates the global positions of mobile robots in a large‐scale area. The key concept is to gradually improve the accuracy of the global localization by fusing sensor information with different characteristics. The sensor observations are the received signal strength indications (RSSIs) of Wi‐Fi devices as network facilities and the range of a laser scanner. First, the RSSI data used for determining certain global areas within which the robot is located are represented as RSSI bins. In addition, the results of the RSSI bins contain the uncertainty of localization, which is utilized for calculating the optimal sampling size of the PF to cover the regions of the RSSI bins. The range data are then used to estimate the precise position of the robot in the regions of the RSSI bins using the core process of the PF. The experimental results demonstrate superior performance compared with other approaches in terms of the success rate of the global localization and the amount of computation for managing the optimal sampling size.     

小型机载激光通信系统设计与验证

针对空空宽带高速通信的需求，设计了小型化机载激光通信系统。仿真分析了300 km、2.5 Gb/s无线激光链路性能，并通过运动仿真台模拟机动环境测试了系统的跟踪与通信性能，其中粗跟踪误差为533.2 μrad(1σ)，精跟踪误差为3.6 μrad(1σ)，测试数据传输240 s，通信误码率为2.82×10-9。仿真与实验验证了该系统用于远距离空空无线激光通信的可行性。     

Adaptive super-twisting fractional-order nonsingular terminal sliding mode control of cable-driven manipulators

This paper proposes a novel adaptive super-twisting fractional-order nonsingular terminal sliding mode (AST–FONTSM) control scheme using time delay estimation (TDE) for the cable-driven manipulators. The designed control scheme utilizes TDE to obtain the estimation of system dynamics, and therefore no system dynamic model information will be required. Afterwards, AST and FONTSM schemes are applied to ensure good control performance in both reaching and sliding mode phases. Due to the adoption of AST scheme, good robustness and high control precision are obtained in the reaching phase, while the boundary information of the lumped uncertainties will be no longer required. Thanks to the utilization of FONTSM error dynamics, fast convergence and accurate tracking and strong robustness can be simultaneously ensured in the sliding mode phase. Corresponding comparative simulation and experimental results demonstrate the effectiveness and superiorities of our proposed method over the existing control methods.     

基于支持向量机的RSA电磁旁路分析方法

针对在旁路分析过程中由于噪声的影响，不能直接观察出RSA的加密过程这一问题，提出结合支持向量机的旁路分析方法，从分类的角度对RSA二进制模幂运算中的平方、乘法操作进行识别，根据密钥与操作的相关性，推断出RSA二进制密钥序列。基于此，对移动设备PCM-9589F凌动主板进行了RSA电磁旁路分析研究，使用串口通信技术实现了对目标设备CPU的旁路电磁信号的采集，并采用基于边界的单类支持向量机的方法，以分类的正确率为70%为阈值，实现了对RSA二进制模幂运算中平方、乘法操作的识别，提取了OpenSSL加密库中1?024位RSA加密算法的二进制密钥序列。相比于传统的简单分析方法，克服了因旁路信号质量低而无法破解密钥的难题。     

多约束下距离加权最优滑模末制导律

为解决多约束下制导炮弹的精确制导问题,采用带有相对距离权函数的最优滑模末制导律,将权函数引入到最优制导律中,通过改变制导炮弹的运动轨迹、运动时间,进而增强制导精度。针对单权函数难以同时满足制导精度与导引头视线角、过载等约束的问题,采用不同权函数的分段加权方法解决加权最优末制导引起的制导问题。结合滑模变结构控制理论,设计分段加权最优滑模末制导律,增强制导系统的抗干扰能力。仿真验证结果表明,该末制导律既能解决过载、导引头视线角、落角等多约束情况下的精确制导问题,同时又具有一定的鲁棒性。