铜蒸汽激光器双闸流管触发系统的研究

研制成用于钢蒸汽激光器的双间流管触发系统。用两个闸流管并联进行交替触发，总输入电功率达7．8kW。低功率运行时，激光器的效率为0．6％与单间流管激光器的效率一致。     

一种简易可靠的射频激光调制器

采用ＰＩＮ电调衰减器、ＴＬ４９４等元件组成了射频（ＲＦ）大功率ＣＯ２激光调制器，调制频率、占空比和调制度单独可调。给出了电路的工作原理和测试结果。     

电解防污用开关恒流源初探

对新研制的两种电解防污开关恒流源所采用的不同逆变器、开关功率管、直流工作电源及取样方式的工作状态、工作特性进行了分析比较。在研制过程中，重点解决了恒流电源工作的安全可靠性、稳定性、抗干扰能力及输出范围宽等问题。     

Contrast‐enhanced wide‐angle high‐speed polarization modulator for active‐retarder 3‐D displays

Abstract— A contrast‐enhanced wide‐angle high‐speed polarization modulator for active‐retarder 3‐D displays is proposed. By using a double liquid‐crystal‐cell structure together with a dedicated driving scheme and an external quarter‐wave retarder, a high‐performance modulator can be realized, resulting in minimized brightness loss and low cross‐talk levels in fast‐refresh time‐multiplexed 3‐D displays.     

Mutant p53 Mediates Sensitivity to Cancer Treatment Agents in Oesophageal Adenocarcinoma Associated with MicroRNA and SLC7A11 Expression

TP53 gene mutations occur in 70% of oesophageal adenocarcinomas (OACs). Given the central role of p53 in controlling cellular response to therapy we investigated the role of mutant (mut-) p53 and SLC7A11 in a CRISPR-mediated JH-EsoAd1 TP53 knockout model. Response to 2 Gy irradiation, cisplatin, 5-FU, 4-hydroxytamoxifen, and endoxifen was assessed, followed by a TaqMan OpenArray qPCR screening for differences in miRNA expression. Knockout of mut-p53 resulted in increased chemo- and radioresistance (2 Gy survival fraction: 38% vs. 56%, p < 0.0001) and in altered miRNA expression levels. Target mRNA pathways analyses indicated several potential mechanisms of treatment resistance. SLC7A11 knockdown restored radiosensitivity (2 Gy SF: 46% vs. 73%; p = 0.0239), possibly via enhanced sensitivity to oxidative stress. Pathway analysis of the mRNA targets of differentially expressed miRNAs indicated potential involvement in several pathways associated with apoptosis, ribosomes, and p53 signaling pathways. The data suggest that mut-p53 in JH-EsoAd1, despite being classified as non-functional, has some function related to radio- and chemoresistance. The results also highlight the important role of SLC7A11 in cancer metabolism and redox balance and the influence of p53 on these processes. Inhibition of the SLC7A11-glutathione axis may represent a promising approach to overcome resistance associated with mut-p53.     

光栅光调制器周期结构的优化分析与实验

针对光栅光调制器的光学调制特点,建立一种可变周期结构的光栅光调制器模型,采用Matlab软件中的数字图像处理方法进行研究。利用傅里叶变换分析两种周期结构的光栅光调制器在频谱面和像面的光场分布,并得到不同周期结构对器件调制对比度的影响。实验得到了两种结构像面的光强输出对比。结果表明:不同周期结构对器件的亮态调制效果影响不大;当器件上下反射面中心对齐,下层反射面在器件周期方向两侧各超出上层光栅面的1/2倍光栅间隙宽度时,器件具有最佳的暗态调制效果,从而得到了光栅光调制器的一种周期结构优化方案。     

多工作模式Σ-Δ型ADC的设计

针对现有Σ-Δ型ADC芯片精度固定、无法测量内部波形,分析了Σ-Δ型A/D转换电路的工作原理,选择合适的参数,提出了一个多工作模式的Σ-Δ型ADC电路设计方案.该方案采用中小规模集成电路实现一阶Σ-Δ调制器、FPGA实现数字滤波器、单片机开发板实现波形和数据显示,用户可通过跳线设置其工作模式,并且可以用示波器观测关键点的波形.测试结果表明,该电路性能稳定,达到了设计要求.     

气压ABS压力调节单元的建模与分析

建立了本实验室所使用的某型号气压ABS压力控制单元的AMESIM模型，对该压力控制单元的动态响应特性进行了仿真。结合该压力控制单元，建立了某客车气压ABS系统的AMESIM模型，通过仿真得到了气压ABS工作过程阀特性与控制效果的关系曲线。     

连续型Δ∑调制器设计综述

Δ∑调制器作为数字转换器中重要的类型,以其较高精度及对CMOS工艺演进的更强适应性得到广泛应用.阐述了Δ∑调制器中连续型的Δ∑调制器的主要设计要点,介绍了国内外在连续型Δ∑调制器上的研究现状,并对相应设计方法进行分类总结.分析了连续Δ∑调制器的工作原理、系统结构、电路误差及模型,对其发展趋势以及面临的挑战进行了总结.结果说明合理地利用新工艺及新型积分器可以有效提高连续型Δ∑调制器的带宽及能效.