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排序方式: 共有6563条查询结果,搜索用时 25 毫秒
1.
Corey Andrews Yiting Xu Michael Kirberger Jenny J. Yang 《International journal of molecular sciences》2021,22(1)
Calmodulin (CaM) is an important intracellular protein that binds Ca2+ and functions as a critical second messenger involved in numerous biological activities through extensive interactions with proteins and peptides. CaM’s ability to adapt to binding targets with different structures is related to the flexible central helix separating the N- and C-terminal lobes, which allows for conformational changes between extended and collapsed forms of the protein. CaM-binding targets are most often identified using prediction algorithms that utilize sequence and structural data to predict regions of peptides and proteins that can interact with CaM. In this review, we provide an overview of different CaM-binding proteins, the motifs through which they interact with CaM, and shared properties that make them good binding partners for CaM. Additionally, we discuss the historical and current methods for predicting CaM binding, and the similarities and differences between these methods and their relative success at prediction. As new CaM-binding proteins are identified and classified, we will gain a broader understanding of the biological processes regulated through changes in Ca2+ concentration through interactions with CaM. 相似文献
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The present study proposes an algorithm for fault detection in terms of condition‐based maintenance with data mining techniques. The proposed algorithm is applied on an aircraft turbofan engine using flight data and consists of two main sections. In the first section, the relationship between engine exhaust gas temperature (EGT) as the main engine health monitoring criterion and other operational and environmental parameters of the engine was modelled using the data‐driven models. In the second section, a data set including EGT residuals, that is, the difference between the actual EGT of the system and the EGT estimated by the developed model in the health conditions of the engine, was created. Finally, faults occurring in each flight were detected based on the identification of abnormal events by a one‐class support vector machine trained by the health condition EGT residual data set. The results indicated that the proposed algorithm was an effective approach for inspecting aircraft engine conditions and detecting faults, with no need for technical knowledge on the interior characteristics of the aircraft engine. 相似文献
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Prediction of methane adsorption content in continental coal-bearing shale reservoir using SLD model
Shale gas, as an important unconventional resource, has drawn global attention. It is mainly composed of adsorption gas and free gas. Adsorption gas content could play an important guiding role on both the selection of favorable perspective area and the exploration and exploitation of shale gas resources. In order to accurately measure adsorption gas content, a new approach was established to predict the adsorption isotherm of methane on shale. Based on the simplified local-density (SLD) method, both the adsorption isotherms of illite, illite/smectite mixed-layer, cholorite and type III kerogen and the total shale rock could be well fitted. The fitting results show good coincidences with the true experimental test data, which proves the method is reasonable and dependable and the prediction results are effective and credible. In addition, the good simulation results show that the SLD parameters can reflect the pore structure characteristics and corresponding adsorption characteristics of the shale samples, which can be used for the quantitative characterization of shale pore system. 相似文献
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为了提高花粉浓度预报的准确率,解决现有花粉浓度预报准确率不高的问题,提出了一种基于粒子群优化(PSO)算法和支持向量机(SVM)的花粉浓度预报模型。首先,综合考虑气温、气温日较差、相对湿度、降水量、风力、日照时数等多种气象要素,选择与花粉浓度相关性较强的气象要素构成特征向量;其次,利用特征向量与花粉浓度数据建立SVM预测模型,并使用PSO算法找出最优参数;然后利用最优参数优化花粉浓度预测模型;最后,使用优化后的模型对花粉未来24 h浓度进行预测,并与未优化的SVM、多元线性回归法(MLR)、反向神经网络(BPNN)作对比。此外使用优化后的模型对某市南郊观象台和密云两个站点进行逐日花粉浓度预测。实验结果表明,相比其他预报方法,所提方法能有效提高花粉浓度未来24 h预测精度,并具有较高的泛化能力。 相似文献
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针对现有混合入侵检测模型仅定性选取特征而导致检测精度较低的问题,同时为了充分结合误用检测模型和异常检测模型的优势,提出一种采用信息增益率的混合入侵检测模型.首先,利用信息增益率定量地选择特征子集,最大程度地保留样本信息;其次,采用余弦时变粒子群算法确定支持向量机参数构建误用检测模型,使其更好地平衡粒子在全局和局部的搜索能力,然后,选取灰狼算法确定单类支持向量机参数构建异常检测模型,以此来提高对最优参数的搜索效率和精细程度,综合提高混合入侵检测模型对攻击的检测效果;最后,通过两种数据集进行仿真实验,验证了所提混合入侵检测模型具有较好的检测性能. 相似文献
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为提高风电预测的精度,提出一种鲸鱼优化支持向量机SVM(support vector machine)的组合预测模型。该模型针对风电序列的非平稳波动特性,首先应用集合经验模态分解技术EEMD(ensemble empirical mode de?composition)将原始风电序列分解为一系列不同特征尺度的子序列;并引入鲸鱼优化算法WOA(whales optimiza?tion algorithm)解决SVM中学习参数选择难的问题,进而对各子序列建立WOA_SVM预测模型;最后,叠加各子序列的预测值以得到最终预测值。仿真表明,所提EEMD_WOA_SVM模型具有较高的风电预测精度,显著优于其他基本模型。 相似文献
8.
This paper proposes a design of control and estimation strategy for induction motor based on the variable structure approach. It describes a coupling of sliding mode direct torque control (DTC) with sliding mode flux and speed observer. This algorithm uses direct torque control basics and the sliding mode approach. A robust electromagnetic torque and flux controllers are designed to overcome the conventional SVM-DTC drawbacks and to ensure fast response and full reference tracking with desired dynamic behavior and low ripple level. The sliding mode controller is used to generate reference voltages in stationary frame and give them to the controlled motor after modulation by a space vector modulation (SVM) inverter. The second aim of this paper is to design a sliding mode speed/flux observer which can improve the control performances by using a sensorless algorithm to get an accurate estimation, and consequently, increase the reliability of the system and decrease the cost of using sensors. The effectiveness of the whole composed control algorithm is investigated in different robustness tests with simulation using Matlab/Simulink and verified by real time experimental implementation based on dS pace 1104 board. 相似文献
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该文针对法律领域民事案件中的“交通事故”类案件进行研究,期望在该“交通事故”数据集上实现自动判案。从“中国裁判文书网”采集14 000条数据文本,并对数据进行人工标注。基于对数据集的分析,分别对数据进行粗粒度和细粒度分类,粗粒度为4类,细粒度为8类。该文使用了三种模型: 基于SVM的模型、基于BI-GRU的模型和基于Attention+BI-GRU的模型。实验结果表明: 在该数据集上,对数据进行粗粒度分类时,基于Attention+BI-GRU的模型F1值为80.26%,基于SVM的模型为77.24%,基于BI-GRU的模型为72.65%。在细粒度分类时,基于BI-GRU的模型F1值为48.59%,基于SVM的模型为38.29%,基于Attention+BI-GRU的模型为40.87%。 相似文献