Diphenyl-Methane Based Thyromimetic Inhibitors for Transthyretin Amyloidosis

Thyromimetics, whose physicochemical characteristics are analog to thyroid hormones (THs) and their derivatives, are promising candidates as novel therapeutics for neurodegenerative and metabolic pathologies. In particular, sobetirome (GC-1), one of the initial halogen-free thyromimetics, and newly synthesized IS25 and TG68, with optimized ADME-Tox profile, have recently attracted attention owing to their superior therapeutic benefits, selectivity, and enhanced permeability. Here, we further explored the functional capabilities of these thyromimetics to inhibit transthyretin (TTR) amyloidosis. TTR is a homotetrameric transporter protein for THs, yet it is also responsible for severe amyloid fibril formation, which is facilitated by tetramer dissociation into non-native monomers. By combining nuclear magnetic resonance (NMR) spectroscopy, computational simulation, and biochemical assays, we found that GC-1 and newly designed diphenyl-methane-based thyromimetics, namely IS25 and TG68, are TTR stabilizers and efficient suppressors of TTR aggregation. Based on these observations, we propose the novel potential of thyromimetics as a multi-functional therapeutic molecule for TTR-related pathologies, including neurodegenerative diseases.     

关于泡沫混凝土稳泡剂的探讨

介绍了泡沫混凝土稳泡剂的概念、作用机理、种类,并且通过例举相关试验,讲解了混凝土稳泡剂的选择及使用方法,以推动泡沫混凝土稳泡剂的研究和发展,提高泡沫混凝土的性能。     

化学镀镍-磷合金复合稳定剂的优化研究

采用正交试验研究了稳定剂硫酸铜、碘酸钾、DL-半胱氨酸和硫酸铈复合使用对化学镀Ni-P合金镀液稳定性、镀速、镀层磷含量和孔隙率等性能的影响变化规律。结果表明,各种稳定剂之间有相互促进作用,综合性能明显优于单一稳定剂,且复合使用采用了清洁的原料,替代了重金属Pb2+;稳定剂硫酸铜、碘酸钾、DL-半胱氨酸和硫酸铈最佳复配的质量浓度分别为:25、20、3和7.5mg/L,镀后测得镀速12.54μm/h、镀液稳定常数91.85%、孔隙率0、镀层磷质量分数为10.25%。     

Isolation of the effect of the hairy layer length on the mechanical properties of waterborne coatings

The effect of the acidic hairy layer length on the interdiffusion of polymer between particles and as a consequence on the mechanical properties of the films produced from waterborne coatings has been studied. In order to isolate this effect, latexes with the same particle diameter and molecular weight but stabilized with poly(acrylic acid)-block-poly(butyl acrylate) (PAA-b-PBA) block copolymers of controlled and different lengths were prepared. Tensile strength measurements showed at the macroscopic level that the presence of AA chains in the particle surface reduced the mechanical properties of the films dried at room temperature, being its effect worse the longer the AA chain length. Higher annealing temperatures erased the negative effect of the acidic hairy layer on mechanical properties. The neutralization with NaOH instead of with NH₄OH also led to worse mechanical properties. These macroscopic results were supported by Fluorescence Resonance Energy Transfer (FRET) experiments that showed that at the microscopic level, the extent of interdiffusion occurred slower when the AA chains in the particles surface increased, the annealing temperature was lower and when NaOH was used as neutralizing agent instead of NH₄OH.     

Innovative Ingredients and Emerging Technologies for Controlling Ice Recrystallization,Texture, and Structure Stability in Frozen Dairy Desserts: A Review

Over the past decade, ice cream manufacturers have developed a strong understanding of the functionality of key ingredients and processing, developing effective explanations for the link between structure forming agents, stability mechanisms, and perceived quality. Increasing demand for products perceived as healthier/more natural with minimal processing has identified a number of new tools to improve quality and storage stability of frozen dairy desserts. Ingredients such as dietary fiber, polysaccharides, prebiotics, alternate sweeteners, fat sources rich in unsaturated fatty acids and ice strucsturing proteins (ISP) have been successfully applied as cryoprotective, texturizing, and structuring agents. Emerging minimal processing technologies including hydrostatic pressure processing, ultrasonic or high pressure assisted freezing, low temperature extrusion and enzymatically induced biopolymers crosslinking have been evaluated for their ability to improve colloidal stability, texture and sensory quality. It is therefore timely for a comprehensive review.     

Effects of MgAlCe‐CO3 layered double hydroxides on the thermal stability of PVC resin

MgAlCe‐CO₃ layered double hydroxides (LDHs) with different Ce/Al molar ratios were prepared by the constant pH coprecipitation method. The synthesized materials were characterized by XRD and FTIR, and the results showed that the hydrotalcite‐like materials have a layered structure. Different LDHs as stabilizers were mixed with PVC resin. The tests of thermal aging and Congo red for the PVC composites were carried out at 180 ± 1°C, respectively. The results showed when MgAlCe‐CO₃‐LDHs were added into PVC as single thermal stabilizers, 3 phr (parts per hundred PVC resin) MgAlCe‐CO₃‐LDH with Ce/Al (molar ratio) = 0.075 has a better stabilizing effect on PVC than others. Compared with single thermal stabilizers (LDHs or Ca/Zn systems), the composite thermal stabilizers including 0.3 g calcium stearate (Cast₂), 1 g zinc stearate (Znst₂), and 3 g MgAlCe‐CO₃‐LDH have significantly enhanced the thermal stability of PVC sample, and the thermal stable time was over 190 min. The main reason could be concluded to the special structure of Ce element and the synergistic reaction among MgAlCe‐CO₃‐LDHs, Cast₂, and Znst₂. © 2010 Wiley Periodicals, Inc. J Appl Polym Sci, 2011     

The final bleaching of eucalypt kraft pulps with hydrogen peroxide: relationship with industrial ECF bleaching history and cellulose degradation

BACKGROUND: The process of chemical pulp bleaching is based for the most part in chlorine dioxide within elemental chlorine free (ECF) technologies. The use of greener alternatives such as bleaching with hydrogen peroxide (P stage) is not widely used owing to selectivity concerns related to transition metal‐catalyzed decomposition reactions. Even at the final stage where peroxide is recognized to boost brightness and improve the brightness stability of the bleached pulp, cellulose degradation often overcomes these advantages. This paper presents the results of studies intended to optimize final peroxide bleaching performance considering two standard ECF industrial bleaching sequences: the conventional DED and the ECF‐light OQ(PO)D (stages name: D—chlorine dioxide; E—alkaline extraction; O—oxygen; Q—chelation, (PO)—hydrogen peroxide pressurized with oxygen). RESULTS: The addition of sodium diethylenetriaminepentaacetate (DTPA) was the most effective option in terms of DED pulp bleachability and selectivity with hydrogen peroxide, as well as in terms of brightness reversion. As regards the OQ(PO)D pulp, a blend of DTPA and magnesium was the most beneficial in those properties. CONCLUSIONS: The choice of the best hydrogen peroxide stabilizer, among the different tested combinations of magnesium and chelants (EDTA and DTPA) studied, in terms of pulp bleachability, bleaching selectivity and brightness reversion is dependent on the impact of the previous bleaching stages on metallic nature and content. The pulp Mg/(Fe + Cu) ratio was highlighted as a process parameter controlling cellulose degradation in peroxide bleaching. Copyright © 2010 Society of Chemical Industry     

中国塑料助剂业发展现状及趋辨分析

综述了中国塑料助剂目前的生产、需求等行业总体状况,重点分析了增塑剂、阻燃剂、热稳定剂的现状及发展趋势,对行业发展提出一些建议。     

航空燃料高温裂解条件下热稳定添加剂的研究进展

介绍了供氢剂和结焦抑制剂两类热稳定剂抑制航空燃料高温（>400 ℃）热裂解期结焦的研究进展。评述了一元、二元供氢剂以及含磷、有机硒、含硫结焦抑制剂的抑焦机理及其抑焦效果,并提出今后的研究方向。     

我国氮肥厂水处理技术的现状与展望（上）

详细地介绍了我国近年来大，中型氮肥厂处理的现状，较全面地总结了水处理工艺和各种水稳剂的使用情况，并提出了今后的发展方向。