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排序方式: 共有10000条查询结果,搜索用时 15 毫秒
1.
Mingchang Lin Yufei Zhang Guosong Chen Ming Jiang 《Small (Weinheim an der Bergstrasse, Germany)》2015,11(45):6065-6070
Glyco‐mimicking nanoparticles (glyco‐NPs) with Förster resonance energy transfer (FRET) donor and acceptor groups formed via dynamic covalent bond of benzoboroxole and sugar from two complementary polymers are prepared. The glyco‐NPs are proved to be quite stable under physiological conditions but sensitive to pH. So the glyco‐NPs can be internalized by dendritic cells with integrity and nontoxicity and then dissociate within the acidic organelles. This particle dissociation is directly observed and visualized in vitro, for the first time via the FRET measurements and fluorescent microscopy. This feature makes controlled release of drug or protein by glyco‐NPs possible, i.e., when model antigen Ovalbumin is loaded in the glyco‐NPs, the released Ovalbumin in dendritic cells stimulates T cells more efficiently than the free Ovalbumin itself as a result of the enhanced antigen processing and presentation. Thus, the results enlighten a bright future of the glyco‐NPs in immunotherapy. 相似文献
2.
Hashim A.
Hashim 《国际强度与非线性控制杂志
》2020,30(10):3848-3870
》2020,30(10):3848-3870
This paper introduces two novel nonlinear stochastic attitude estimators developed on the Special Orthogonal Group with the tracking error of the normalized Euclidean distance meeting predefined transient and steady‐state characteristics. The tracking error is confined to initially start within a predetermined large set such that the transient performance is guaranteed to obey dynamically reducing boundaries and decrease smoothly and asymptotically to the origin in probability from almost any initial condition. The proposed estimators produce accurate attitude estimates with remarkable convergence properties using measurements obtained from low‐cost inertial measurement units. The estimators proposed in continuous form are complemented by their discrete versions for the implementation purposes. The simulation results illustrate the effectiveness and robustness of the proposed estimators against uncertain measurements and large initialization error, whether in continuous or discrete form. 相似文献
3.
讨论了在VMI管理思想下对具有随机需求特性的多客户库存分配问题 ,重点论述了有效近似算法的设计过程 ,最后基于一组模拟数据给出了一个算例。 相似文献
4.
声波测井换能器的激发响应由换能器振动时所表现出来的动态阻抗和激发电路参数决定。而换能器的动态(阻抗)参数随压电晶体及其装配方式(力学边界条件)改变。为了测量换能器动态参数的影响,采用声波测井仪器常用的压电晶体和升压变压器,通过改变激发脉冲宽度和直流电压进行了实验,结果发现:在换能器两端的瞬态响应中,一共有三个二阶网络响应,分别对应于不同的频率。最低的一个影响声波测井波形的基线、与换能器主频接近的一个决定激发效率以及电路与压电晶体之间的匹配关系,是激发电路设计中比较关键的,其参数可以通过导纳圆测量仪器得到。 相似文献
5.
论文提出利用用户提供的个性化信息来随机产生关联大素数,保证了素数选取的随机化、个性化,提高了RSA算法的安全性。 相似文献
6.
Kruk Menno R.; Halász József; Meelis Wout; Haller József 《Canadian Metallurgical Quarterly》2004,118(5):1062
Aggressive behavior induces an adrenocortical stress response, and sudden stressors often precipitate violent behavior. Experiments in rats revealed a fast, mutual, positive feedback between the adrenocortical stress response and a brain mechanism controlling aggression. Stimulation of the aggressive area in the hypothalamus rapidly activated the adrenocortical response, even in the absence of an opponent and fighting. Hypothalamic aggression, in turn, was rapidly facilitated by a corticosterone injection in rats in which the natural adrenocortical stress response was prevented by adrenalectomy. The rapidity of both effects points to a fast, mutual, positive feedback of the controlling mechanisms within the time frame of a single conflict. Such a mutual facilitation may contribute to the precipitation and escalation of violent behavior under stressful conditions. (PsycINFO Database Record (c) 2010 APA, all rights reserved) 相似文献
7.
8.
The effects of parameter uncertainty on optimal policy have been a matter of interest for academics, and even for some policymakers,
for a long time. Two lines of literature have developed analytical results on this matter. The first line uses static models
and the second dynamic models. In this dynamic line most of the results are confined to models with a single state and a single
control variable.
In this paper we want to encourage the analysis of more general dynamic cases. To do so, the results in the dynamic line are
extended from one-state and one-control finite horizon models to models with a pair of control variables. We then discuss
some of the hurdles which must be surmounted for the results to be made more general and suggests some lines for further research.
JEL classification: C61; E61 相似文献
9.
叙述了二代近贴聚焦像增强器批量生产所用真空设备性能及特点,同时给出了管子工艺考核结果及管子纳秒时间响应特性。工艺考核结果表明,制管工艺可靠、性能稳定,管子批量生产合格率大于70%。 相似文献
10.
This paper proposes an original method for obtaining analytical approximations of the invariant probability density function of multi-dimensional Hamiltonian dissipative dynamic systems under Gaussian white noise excitations, with linear non-conservative parts and nonlinear conservative parts. The method is based on an exact result and a heuristic argument. Its pertinence is attested by numerical tests. 相似文献