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1.
The germline carrier of the BRCA1 pathogenic mutation has been well proven to confer an increased risk of breast and ovarian cancer. Despite BRCA1 biallelic pathogenic mutations being extremely rare, they have been reported to be embryonically lethal or to cause Fanconi anemia (FA). Here we describe a patient who was a 48-year-old female identified with biallelic pathogenic mutations of the BRCA1 gene, with no or very subtle FA-features. She was diagnosed with ovarian cancer and breast cancer at the ages of 43 and 44 and had a strong family history of breast and gynecological cancers.  相似文献   
2.
在AlSi7Mg铝合金表面制备单道和多道WC增强镍基合金激光熔覆层,研究了熔覆层的显微组织、物相组成、稀释率和显微硬度.结果表明:当激光扫描速度由3.3 mm·s-1增至6.0 mm·s-1时,单道激光熔覆层中的气孔和裂纹变少;在扫描速度4.6 mm·s-1、光斑直径1.0 mm、搭接率20%条件下,多道熔覆层中WC颗粒主要分布在熔覆区与过渡区界面处,裂纹和气孔分别位于搭接处和熔覆层底部;第1道熔覆层及最后1道(第5道)熔覆层的稀释率比第2~4道的高约10%;WC增强镍基合金熔覆层中生成了AlNi、Al3 Ni、M7 C3、M23 C3等析出相,其平均稀释率约45%,显微硬度约1100 HV.  相似文献   
3.
Heparanase (Hpse) is an endo-β-D-glucuronidase capable of cleaving heparan sulfate side chains. Its upregulated expression is implicated in tumor growth, metastasis and angiogenesis, thus making it an attractive target in cancer therapeutics. Currently, a few small molecule inhibitors have been reported to inhibit Hpse, with promising oral administration and pharmacokinetic (PK) properties. In the present study, a ligand-based pharmacophore model was generated from a dataset of well-known active small molecule Hpse inhibitors which were observed to display favorable PK properties. The compounds from the InterBioScreen database of natural (69,034) and synthetic (195,469) molecules were first filtered for their drug-likeness and the pharmacophore model was used to screen the drug-like database. The compounds acquired from screening were subjected to molecular docking with Heparanase, where two molecules used in pharmacophore generation were used as reference. From the docking analysis, 33 compounds displayed higher docking scores than the reference and favorable interactions with the catalytic residues. Complex interactions were further evaluated by molecular dynamics simulations to assess their stability over a period of 50 ns. Furthermore, the binding free energies of the 33 compounds revealed 2 natural and 2 synthetic compounds, with better binding affinities than reference molecules, and were, therefore, deemed as hits. The hit compounds presented from this in silico investigation could act as potent Heparanase inhibitors and further serve as lead scaffolds to develop compounds targeting Heparanase upregulation in cancer.  相似文献   
4.
Catalysis Letters - We converted agro-waste Custard Apple Peels (CAP) to ash via thermal treatment, on which Pd(OAc)2 was immobilized easily that produced a low-cost, highly efficient Pd/CAP-ash...  相似文献   
5.
基于现有热成形零件冷弯性能不足、氢脆敏感性强等共性技术问题,在22MnB5钢的基础上采用Nb、V微合金化的设计思路,对试验钢的显微组织、淬透性和极限尖冷弯性能进行研究。结果表明:微合金化前后22MnB5热成形钢的显微组织均为全马氏体,但是微合金化后的试验钢组织更为细小;Nb-V微合金化能有效提高22MnB5热成形钢的淬透性,其淬硬层深度达到13~14 mm,并且试验钢的极限尖冷弯角达到58°~72°,进一步拓宽了热冲压成形的工艺窗口。综合分析试验钢微观组织、淬透性能及极限尖冷弯性能的检测结果,添加0.04%Nb和0.04%V实现复合微合金化,提升材料的综合强塑性,满足了高冷弯性能汽车零部件用材需求。  相似文献   
6.
对航天用紧固件TC4钛合金棒材进行固溶时效处理,对棒材不同位置进行显微组织观察、硬度和室温拉伸性能检测。结果表明:TC4钛合金棒材经固溶时效后表面至心部的组织与性能受冷却速度的影响呈现显著差异。固溶时效后的显微组织由稳定的等轴α相、弥散的马氏体α′相和亚稳定β相组成,试样端面上因冷却速度相差不大,次生α相的形态和含量没有明显差异;中部截面上边部至心部的次生α相含量逐渐增多,同时次生α相片层厚度逐渐增大并趋于等轴化。端面上不同位置显微硬度值没有明显差异,但中部截面上由边部至心部的显微硬度值呈总体降低趋势,且中部截面上边部的显微硬度值与端面相差不大。试样心部因固溶过程中冷却缓慢,整体试样的室温拉伸性能明显低于去除心部的试样。  相似文献   
7.
The aim of this study was to determine the influence of severe plastic deformation processing and the changes in microstructure resulting therefrom on the corrosion resistance of an Al–Mg–Si alloy. The alloy was processed using incremental equal channel angular pressing, which caused a reduction in grain size from 15 to 0.9 µm. The grain refinement was accompanied by an increase in the number of grain boundaries and dislocations, and by changes in grain orientation. However, there was no change in the size and number of intermetallic particles, which presumably resulted in a constant number of galvanic couplings. Electrochemical experiments revealed only slight differences between the samples before and after processing. Higher potential transients/oscillations upon immersion and increased corrosion currents in the vicinity of corrosion potential point to slightly higher reactivity of the most refined material. This indicates that intermetallic particles are the most crucial microstructural elements in terms of corrosion resistance. Their impact exceeds that of grain boundaries, in particular, at the stage of corrosion initiation. The development of corrosion attack is controlled more by the microstructure of the matrix as the grain refinement resulted in a less pronounced corrosion attack in comparison with the coarse-grained sample.  相似文献   
8.
为解决非对称断面钢轨镦粗时的波浪变形问题,设计了局部镦粗成套装置,利用已有的锻造生产线,有效地控制了非对称断面钢轨镦粗时产生的失稳和轨肢波浪变形,减少了模具更换次数;同时,设计的镦粗测量和显示装置,可精确控制镦粗量,保证镦粗成形质量稳定。经实物验证,采用本装置及工艺,单根镦粗时间由原工艺的60 min降低至8 min,效率提高了7倍以上;镦粗钢轨一次合格率达100%,较原工艺合格率提高了3倍以上。利用已有的锻造生产线,减少了设备投入,降低了投资成本,在工艺布局上可以减少镦粗工序的生产区域,优化了车间的工艺布局。最后,通过实物验证了方案可行性,并确定了工艺参数,可用于指导实际生产。  相似文献   
9.
Ce:Y3Al5O12 transparent ceramics (TCs) with appropriate emission light proportion and high thermal stability are significant to construct white light emitting diode devices with excellent chromaticity parameters. In this work, strategies of controlling crystal-field splitting around Ce3+ ion and doping orange-red emitting ion, were adopted to fabricate Ce:(Y,Tb)3(Al,Mn)5O12 TCs via vacuum sintering technique. Notably, 85.4 % of the room-temperature luminescence intensity of the TC was retained at 150 °C, and the color rendering index was as high as 79.8. Furthermore, a 12 nm red shift and a 16.2 % increase of full width at half maximum were achieved owing to the synergistic effects of Tb3+ and Mn2+ ions. By combining TCs with a 460 nm blue chip, a warm white light with a low correlated color temperature of 4155 K was acquired. Meanwhile, the action mechanism of Tb3+ ion and the energy transfer between Ce3+ and Mn2+ ions were verified in prepared TCs.  相似文献   
10.
探讨了13X分子筛对不同初始pH的Pb(Ⅱ)溶液中Pb(Ⅱ)的吸附量、吸附速率及吸附机理,以及分子筛的碱性对溶液pH的改变。结果表明,1 g/L的13X分子筛的碱性为10^-5mol/g,Pb(Ⅱ)溶液pH为3.0~9.0时,分子筛自身的碱性会使反应溶液pH升高。当Pb(Ⅱ)溶液pH由3.0升高至12.0时,分子筛对Pb(Ⅱ)的去除率由65.1%增大至99.7%。Pb(Ⅱ)溶液pH为5.0~7.0时,13X分子筛对Pb(Ⅱ)的吸附符合拟二级动力学方程,吸附速率k_2由1.72 g/(mmol·min)增大至2.85 g/(mmol·min),而当pH达到Pb(Ⅱ)开始形成沉淀时(pH>7.0),吸附速率显著降低。13X分子筛对Pb(Ⅱ)的去除机理主要为离子交换,当溶液内开始出现Pb(Ⅱ)的沉淀时,离子交换量降低,pH=10时,离子交换量仅占总去除量的30.2%。反应过程中由于13X分子筛自身的碱性和Pb(Ⅱ)易形成羟和配离子的特性,反应体系pH会在pH<7.0形成酸性缓冲区域和8.0~10.0范围内形成碱性缓冲区域。  相似文献   
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