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排序方式: 共有4452条查询结果,搜索用时 15 毫秒
1.
Kexin Jiao Laurence J. Walsh Sao Ivanovski Pingping Han 《International journal of molecular sciences》2021,22(9)
Periodontitis is a chronic complex inflammatory disease associated with a destructive host immune response to microbial dysbiosis, leading to irreversible loss of tooth-supporting tissues. Regeneration of functional periodontal soft (periodontal ligament and gingiva) and hard tissue components (cementum and alveolar bone) to replace lost tissues is the ultimate goal of periodontal treatment, but clinically predictable treatments are lacking. Similarly, the identification of biomarkers that can be used to accurately diagnose periodontitis activity is lacking. A relatively novel category of molecules found in oral tissue, circular RNAs (circRNAs) are single-stranded endogenous, long, non-coding RNA molecules, with covalently circular-closed structures without a 5’ cap and a 3’ tail via non-classic backsplicing. Emerging research indicates that circRNAs are tissue and disease-specific expressed and have crucial regulatory functions in various diseases. CircRNAs can function as microRNA or RNA binding sites or can regulate mRNA. In this review, we explore the biogenesis and function of circRNAs in the context of the emerging role of circRNAs in periodontitis pathogenesis and the differentiation of periodontal cells. CircMAP3K11, circCDK8, circCDR1as, circ_0062491, and circ_0095812 are associated with pathological periodontitis tissues. Furthermore, circRNAs are expressed in periodontal cells in a cell-specific manner. They can function as microRNA sponges and can form circRNA–miRNA–mRNA networks during osteogenic differentiation for periodontal-tissue (or dental pulp)-derived progenitor cells. 相似文献
2.
《International Journal of Hydrogen Energy》2022,47(59):24843-24851
Lithium alanate (LiAlH4) is a material that can be potentially used for solid-state hydrogen storage due to its high hydrogen content (10.5 wt%). Nevertheless, a high desorption temperature, slow desorption kinetic, and irreversibility have restricted the application of LiAlH4 as a solid-state hydrogen storage material. Hence, to lower the decomposition temperature and to boost the dehydrogenation kinetic, in this study, we applied K2NiF6 as an additive to LiAlH4. The addition of K2NiF6 showed an excellent improvement of the LiAlH4 dehydrogenation properties. After adding 10 wt% K2NiF6, the initial decomposition temperature of LiAlH4 within the first two dehydrogenation steps was lowered to 90 °C and 156 °C, respectively, that is 50 °C and 27 °C lower than that of the аs-milled LiAlH4. In terms of dehydrogenation kinetics, the dehydrogenation rate of K2NiF6-doped LiAlH4 sample was significantly higher as compared to аs-milled LiAlH4. The K2NiF6-doped LiAlH4 sample can release 3.07 wt% hydrogen within 90 min, while the milled LiAlH4 merely release 0.19 wt% hydrogen during the same period. According to the Arrhenius plot, the apparent activation energies for the desorption process of K2NiF6-doped LiAlH4 are 75.0 kJ/mol for the first stage and 88.0 kJ/mol for the second stage. These activation energies are lower compared to the undoped LiAlH4. The morphology study showed that the LiAlH4 particles become smaller and less agglomerated when K2NiF6 is added. The in situ formation of new phases of AlNi and LiF during the dehydrogenation process, as well as a reduction in particle size, is believed to be essential contributors in improving the LiAlH4 dehydrogenation characteristics. 相似文献
3.
Uwe Altrock 《建筑学研究前沿(英文版)》2022,11(5):783-794
This paper asks how the livability of socially disadvantaged urban neighborhoods can be improved with the help of publicly funded area-based urban regeneration. It builds on the history of area-based regeneration policies in Germany aiming at upgrading and resolving urban problems at the neighborhood level. Its main argument is as follows. First, the fate of conventional physical upgrading policies focusing on the livability of deprived urban areas depends on the development environment. While successful upgrading sometimes makes inner-city neighborhoods so attractive that they run into a trend towards gentrification and displacement of the urban poor, the stabilization of less privileged areas cannot always be guaranteed. Second, alternative approaches are needed, linking limited physical upgrading with socially oriented policies, building on strategies like neighborhood management and empowerment. Third, they can make a substantial contribution to stabilizing deprived neighborhoods, thereby improving the general living conditions and the opportunities of the urban poor. However, they require at least some permanent intervention. Thus, they transcend the logic of area-based regeneration normally limited to restoring faith into the private real estate market and thereby directing inward investment into them that improves the quality of the physical environment. Fourth, they are hardly able to overcome significant negative stigmatization in cities that are severely hit by economic downturn and population decline. This is especially true when they act as arrival areas for consecutive waves of migrants, making it necessary to redefine the role of those areas in cities and accepting their high concentration of urban problems as a starting point for different area-based policies dealing with them. The key empirical background of the paper is the German system of urban development grants and an evaluation of the so-called program of “socially integrative city”. 相似文献
4.
《International Journal of Hydrogen Energy》2022,47(19):10799-10801
A recent paper titled “A continuous hydrogen absorption/desorption model for metal hydride reactor coupled with PCM as heat management and its application in the fuel cell power system”, published in the International Journal of Hydrogen Energy, describes the desorption kinetics modification without which the authors of this paper was unable to obtain experimental dependencies in the simulation during desorption. According to the opinion of the author of this commentary, modification of the kinetics is not required, and experimental results can be obtained using the standard kinetics by replacing the inlet/outlet boundary condition with a better one. 相似文献
5.
Filip Hromcik Jan Vokurka Michal Kyr Lydie Izakovicova Holla 《European Journal of Lipid Science and Technology》2021,123(2):2000259
The topical application of aspirin and omega-3 polyunsaturated fatty acids (PUFAs) may trigger the resolution of inflammation by inducing the biosynthesis of pro-resolvers such as lipoxins and resolvins while also avoiding the side effects of systemic aspirin intake. This study assessed the effect of enhanced granulation tissue (EGT) on periodontal tissue regeneration through the local application of aspirin and omega-3 PUFAs directly to granulation tissue (GT) during periodontal surgery. This randomized controlled experiment assesses 38 pockets in 19 patients. In every patient, two similar intrabony periodontal defects are treated with an open flap debridement, one with EGT (GT extracted, enhanced with aspirin and omega-3 PUFAs, and replaced) and the other with standard GT removal. Clinical attachment level (CAL) and probing pocket depth (PPD) are assessed at baseline and 2 and 6 months after surgery. The experimental protocol (EGT) results in a greater CAL gain as compared to that in the controls at 6 months (p < 0.05), while PPD reduction is not affected. The retained GT does not compromise healing. EGT is proposed as a promising, inexpensive, and simple method that may improve the outcome of periodontal regenerative treatment. However, the described protocol requires optimization and further assessment. Practical Applications : The biosynthesis of mediators including resolvins and lipoxins triggered by aspirin and omega-3 PUFAs promote the resolution of inflammation, eventually leading to faster regeneration of inflamed tissues. While granulation tissue is a necessary component in wound healing, enhancing granulation tissue with aspirin and omega-3 PUFAs results in CAL gain in the surgical treatment of periodontal defects. Retained granulation tissue does not compromise periodontal healing. The EGT strategy is an inexpensive and simple method that may improve the clinical outcomes of regenerative periodontal procedures. 相似文献
6.
Douglas Weber David Patsch Annika Neumann Dr. Margit Winkler Prof. Dr. Dörte Rother 《Chembiochem : a European journal of chemical biology》2021,22(10):1823-1832
Accessing aldehydes from carboxylate moieties is often a challenging task. In this regard, carboxylate reductases (CARs) are promising catalysts provided by nature that are able to accomplish this task in just one step, avoiding over-reduction to the alcohol product. However, the heterologous expression of CARs can be quite difficult due to the excessive formation of insoluble protein, thus hindering further characterization and application of the enzyme. Here, the heterologous production of the carboxylate reductase from Nocardia otitidiscaviarum (NoCAR) was optimized by a combination of i) optimized cultivation conditions, ii) post-translational modification with a phosphopantetheinyl transferase and iii) selection of an appropriate expression strain. Especially, the selection of Escherichia coli tuner cells as host had a strong effect on the final 110-fold increase in the specific activity of NoCAR. This highly active NoCAR was used to reduce sodium benzoate to benzaldehyde, and it was successfully assembled with an in vitro regeneration of ATP and NADPH, being capable of reducing about 30 mM sodium benzoate with high selectivity in only 2 h of reaction. 相似文献
7.
Qianqian Liu Yu-Jin Kim Gwang-Bum Im Jintao Zhu Yuzhou Wu Yijing Liu Suk Ho Bhang 《Advanced functional materials》2021,31(12):2008171
Inorganic nanoparticles (NPs) offer significant advantages to the biomedical field owing to their large surface area, controllable structures, diverse surface chemistry, and unique optical and physical properties. Researchers worldwide have shown that inorganic NPs and the released metal ions can act as therapeutic agents in targeted tissues or to cure various diseases without acute toxicity. In this progress report, the recent developments in inorganic NPs with different compositions directly used as therapeutics are discussed. First, the recent convergence of nanotechnology and biotechnology in biomedical applications as well as the unique functions, features, and advantages of inorganic NPs in biomedical applications are summarized. Thereafter, the biological effects of inorganic compositions in NPs which include balancing the intracellular redox environment, regulating the specific cellular signaling and cellular behaviors, and apoptosis are explained. In addition, the emerging therapeutic applications of inorganic NPs in various diseases are exemplified. Finally, the perspectives and challenges for overcoming the weaknesses of inorganic NPs as therapeutics are discussed. By carefully considering and investigating the biological effects of inorganic NPs and metal ions released from NPs, more promising inorganic NPs based therapeutic agents can be developed. 相似文献
8.
《International Journal of Hydrogen Energy》2021,46(66):33197-33205
Plumbene, a recently discovered 2D material, has been examined for hydrogen storage. First principles calculations have been performed to investigate the hydrogen adsorption on pristine plumbene monolayer. The hydrogen molecule prefers to adsorb on three adsorption sites, i.e. H (hollow-site), T (top-site) and B (bond-site), of plumbene surface with desired adsorption energy. The adsorption energy is highest (−149 meV) at hollow site and lowest (−104 meV) at bond site. One side hydrogen decorated plumbene exhibit 3.37 wt% Hydrogen Gravimetric Density (HGD). Whereas 6.74 wt% (HGD), with the average adsorption energy of −117 meV/H2, has been achieved in both side hydrogen decorated plumbene monolayer. Applied electric field can effectively controls the adsorption and desorption processes. Positive electric field makes the adsorption strong while the negative electric field results in weakening of hydrogen adsorption. It means electric field act as a switch to store and release hydrogen with good control and usage selectivity. Present study reveals that the plumbene is a strong candidate for hydrogen storage to meet the desired target of HGD suggested by U.S. Department of Energy by the year 2021. 相似文献
9.
10.
This paper considers thermochemical recuperation (TCR) of waste-heat using natural gas reforming by steam and combustion products. Combustion products contain steam (H2O), carbon dioxide (CO2), and ballast nitrogen (N2). Because endothermic chemical reactions take place, methane steam-dry reforming creates new synthetic fuel that contains valuable combustion components: hydrogen (H2), carbon monoxide (CO), and unreformed methane (CH4). There are several advantages to performing TCR in the industrial furnaces: high energy efficiency, high regeneration rate (rate of waste-heat recovery), and low emission of greenhouse gases (CO2, NOx). As will be shown, the use of TCR is significantly increasing the efficiency of industrial furnaces – it has been observed that TCR is capable of reducing fuel consumption by nearly 25%. Additionally, increased energy efficiency has a beneficial effect on the environment as it leads to a reduction in greenhouse gas emissions. 相似文献