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1.
Different types of anxiety disorders have become the number one mental health issue in developed countries. The search for new, safer and effective drug-like molecules among naturally derived substances faces two difficulties: an efficient method of isolation compounds with a high-purity and high-throughput animal model for activity assay. Thus, the aim of the present study was to isolate by liquid–liquid chromatography high-purity rare coumarins from the fruits of Seseli devenyense Simonk. and evaluate their anxiolytic effect (defined as reversed thimotaxis) using a 5-days post-fertilization (dpf) Danio rerio larvae model. Liquid–liquid chromatography enabled the isolation of one simple hydroxycoumarin (devenyol) and four pyranocoumarins (cis-khellactone, d-laserpitin, isolaserpitin and octanoyllomatin). The anxiolytic effect was defined as a decrease in the time spent in the boundaries of the living space (also described as reversed thigmotaxis). Our results show that all isolated courmarins exerted a significant influence on the anxiety behavior (anxiolytic activity) in the zebrafish larvae model. According to our knowledge, this is the first report of anxiolytic activity of pyranocoumarins and devenyol.  相似文献   
2.
ABSTRACT

People around the world spend hours of their daily lives using smartphones; therefore, it is important to conduct cross-cultural research on the effects of smartphone use on health and well-being as culture influences values, motivations and communication patterns. The purpose of this study was to explore 5 popular uses of the smartphone – messaging, browsing the Internet, posting social content, reading social content, and playing games – how they relate to anxiety and depression scores, and how they vary depending on the country of the participants: Spain, the United States, and Colombia. In all three countries the ranking of most popular uses was the same: (1) Messaging, (2) Reading social content, and (3) Browsing the Internet. In the USA, game playing contributed to anxiety scores whereas reading social content was a protective factor; regarding depression scores, text messaging was a contributing factor. In Spain, browsing the Internet contributed to anxiety scores; regarding depression scores, messaging was a contributing factor and posting social content was a protective factor. In Colombia, no specific use influenced anxiety scores; regarding depression scores, only game playing was a protective factor. Our results showed that in all the countries, problematic smartphone use contributed to anxiety scores.  相似文献   
3.
4.
This paper outlines changes to the ocular surface caused by contact lenses and their degree of clinical significance. Substantial research and development to improve oxygen permeability of rigid and soft contact lenses has meant that in many countries the issues caused by hypoxia to the ocular surface have largely been negated. The ability of contact lenses to change the axial growth characteristics of the globe is being utilised to help reduce the myopia pandemic and several studies and meta-analyses have shown that wearing orthokeratology lenses or soft multifocal contact lenses can reduce axial length growth (and hence myopia).However, effects on blinking, ptosis, the function of Meibomian glands, fluorescein and lissamine green staining of the conjunctiva and cornea, production of lid-parallel conjunctival folds and lid wiper epitheliopathy have received less research attention. Contact lens wear produces a subclinical inflammatory response manifested by increases in the number of dendritiform cells in the conjunctiva, cornea and limbus. Papillary conjunctivitis is also a complication of all types of contact lenses. Changes to wear schedule (daily disposable from overnight wear) or lens materials (hydrogel from SiHy) can reduce papillary conjunctivitis, but the effect of such changes on dendritic cell migration needs further study. These changes may be associated with decreased comfort but confirmatory studies are needed. Contact lenses can affect the sensitivity of the ocular surface to mechanical stimulation, but whether these changes affect comfort requires further investigation.In conclusion, there have been changes to lens materials, design and wear schedules over the past 20+ years that have improved their safety and seen the development of lenses that can reduce the myopia development. However, several changes to the ocular surface still occur and warrant further research effort in order to optimise the lens wearing experience.  相似文献   
5.
在“互联网+”大环境下,以用户价值为导向、加速供需双方实现技术转移、各取所需为核心的,以产业链整合、加强横向用户关系圈扩展、助力进一步解决产学研信息不对称的,以扩大产学研合作范围、提升产学研合作成效为目标的产学研合作生态服务模式应运而生.基于产学研合作生态服务模式,构建生态服务模型,应用于实践,建设“互联网+产学研合作智能服务平台”,提供多样化的产学研内容、社交和对接生态服务,并取得了显著的成效.  相似文献   
6.
学生党支部是学生学风建设的重要力量。文章分析了当前高校学风状况及成因,阐述了学生党支部工作特点,并进行了创新学风建设实践的思考,从学生党支部在思想政治教育中的功能和工作方式等角度,论述了学生党支部开展学风建设的路径及条件保障。  相似文献   
7.
With the rapid development of artificial intelligence (AI), AI anxiety has emerged and is receiving widespread attention, but research on this topic is not comprehensive. Therefore, we investigated the dimensions of AI anxiety using the theoretical model of integrated fear acquisition and a questionnaire survey. A total of 494 valid questionnaires were recovered. Through a first-order confirmatory factor analysis (CFA), a factor model of AI anxiety was constructed, and eight factors of AI anxiety were verified. Then, a second-order CFA was applied to verify the adaptation of the factor structure of AI anxiety to fear acquisition. We identified four dimensions of AI anxiety and proposed a theory of AI anxiety acquisition that illustrates four pathways of AI anxiety acquisition. Each pathway includes two factors that cause AI anxiety. We conclude by analyzing the limitations of current AI anxiety research and proposing a broader research agenda for AI anxiety.  相似文献   
8.
以《城市规划学刊》《规划师》《国际城市规划》为文献来源,依托中国知网(CNKI)文献计量可视化平台,分析以上期刊文献的关键词、文献共被引、文献指数等,结合对近3年相关中央文件的解读,总结我国城乡规划研究动态:①整体研究趋势为经典问题始终延续、前沿问题不断涌现;②经典问题包括:法定规划、问题导向的城市设计、国情政策导向的城镇化研究;③涌现的前沿问题包括新型城镇化、生态城市、旅游规划、产城融合;④未来研究趋势一方面延续新型城镇化、生态城市等领域的研究,另一方面将展开对乡村的系统性研究、对本土规划理论的构建以及健康与安全城市研究。  相似文献   
9.
撰写英文论文是科研人员必备的基本功,学习撰写英文文章也是每一个研究生的必修课。只有掌握撰写论文的技巧,并通过反复实践,才能加强自身的研究能力。本文从英文文献的阅读习惯出发,通过整个篇章的分析、文章结构的安排和逆向梳理法运用,对如何培养准确清楚的表达和撰写化学专业英语论文的能力进行了阐述。  相似文献   
10.
This paper uses a mixed-methods approach to examine the relation between online academic disclosure and academic performance. A multi-ethnic sample of college students (N = 261; male = 66; female = 195; M age ≈ 22 years) responded to open-ended questions about their Facebook use. Thematic analysis revealed that over 14% of the Facebook wall posts/status updates (N = 714) contained academic themes; positive states were more frequent than negative and neutral states and students with lower GPAs expressed negative states more often. A path analysis suggested that academic performance may determine college students’ Facebook use, rather than the reverse. Implications for student support services are discussed.  相似文献   
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