微间隙共形圆柱接触力模型的适用性分析

针对目前间隙铰接副接触力模型无法有效表述不同材料耗散阻尼效应,以及不适用于微间隙共形接触的问题,分析各种接触力模型中弹性接触力和耗散阻尼力计算方法的优缺点,提出一种普适性的圆柱内接触力分析模型。该模型将接触力描述为接触深度的显式函数,并将其适用范围有效地扩展至微间隙和低恢复系数工况。采用含间隙铰接副的曲柄-滑块机构进行动力学分析,对所提出接触力进行验证,计算结果表明:所提出的普适性接触力模型体现了微间隙时更高的接触刚度和低恢复系数时显著的阻尼效应,从而可为不同材料和间隙尺寸的间隙铰接副力学分析提供更为完备的计算模型。     

直缝埋弧焊管生产线预弯机振动原因分析及预防措施

为了解决直缝埋弧焊管生产线预弯机在工作过程中因为剧烈振动，造成提升环螺栓频繁断裂等问题，通过测量油缸及下梁的水平位移，将油管连接的平板导向结构改为楔形导向结构，并对油缸上升过程中的相关参数进行了调整。结果表明，通过新增导向板间隙调整的楔块结构，提高了导向精度；增大提升环与活塞杆件的安装间隙，降低了提升环连接螺栓因为振动引起的干涉受力，解决了提升环螺栓频繁断裂的问题；增大减速斜坡行程控制参数设置量，降低了上升过程中的振动，实现了预弯机的平稳工作。     

球型惯性元件配合间隙差动共焦精密测量方法

配合间隙是决定球型惯性器件精度和可靠性的关键参数之一,针对球型惯性器球面元件表面有缺口且未完全抛光导致曲率半径难以精确测量,进而难以准确控制球碗、球冠配合间隙瓶颈问题,提出了一种球面惯性元件配合间隙激光差动共焦高精度方法。该方法利用抗散射的激光差动共焦曲率半径测量方法分别对球碗、球冠的曲率半径进行测量,然后利用差动共焦曲率半径测量系统测得的球碗和球冠的半径差来控制球型惯性器球面的配合间隙。理论分析与实验验证表明:该方法测量球冠和球碗配合间隙的相对扩展不确定度优于20×10~(-6),其为惯性器件球冠和球碗配合间隙的高精度测量与控制提供了一种全新的技术手段。     

连续波脉冲器发生原理及参数影响规律研究

连续波脉冲器是随钻测量的核心部件。为了探讨连续波脉冲器压力波发生原理及参数影响规律,基于计算流体力学相关理论与方法,建立了连续波脉冲器流场数值仿真模型,仿真分析了连续波脉冲器的流场特征。仿真结果表明:转子周期性往复开关过程中,连续波脉冲器产生流量波和压力波,流量波上、下游相位相同,压力波上、下游相位相反;压力波幅值与脉冲器控制参数相关,幅值随频率与定转子间隙的增大而减小;压力波幅值与钻井水力参数相关,随流体排量和密度的增大而增大,流体黏度对幅值影响可以忽略。研究结果对连续波脉冲器的现场应用具有一定的理论指导作用。     

月柿提取物体外抗氧化活性研究

目的以月柿提取物为原料,研究其对2,2-联苯基-1-苦基肼基(1,1-diphenyl-2-picrylhydrazyl,DPPH)自由基的清除能力,并测定其多酚类物质没食子酸的含量。方法检测波长为518 nm,反应时间为40 min条件下,以IC_(50)值(清除率为50%时,抗氧化剂的浓度值)作为抗氧化能力评价指标,并采用高效液相色谱法测定其没食子酸含量。结果月柿提取物对于DPPH自由基有良好的清除作用,其IC50值为0.1868 mg/mL,与常用抗氧化剂作用相当,且月柿提取物中没食子酸含量为1.65 g/kg。结论月柿提取物具有很强抗氧化活性,作为化妆品及功能性食品原料有广阔的开发前景。     

The Critical Role of Passive Permeability in Designing Successful Drugs

Passive permeability is a key property in drug disposition and delivery. It is critical for gastrointestinal absorption, brain penetration, renal reabsorption, defining clearance mechanisms and drug-drug interactions. Passive diffusion rate is translatable across tissues and animal species, while the extent of absorption is dependent on drug properties, as well as in vivo physiology/pathophysiology. Design principles have been developed to guide medicinal chemistry to enhance absorption, which combine the balance of aqueous solubility, permeability and the sometimes unfavorable compound characteristic demanded by the target. Permeability assays have been implemented that enable rapid development of structure-permeability relationships for absorption improvement. Future advances in assay development to reduce nonspecific binding and improve mass balance will enable more accurately measurement of passive permeability. Design principles that integrate potency, selectivity, passive permeability and other ADMET properties facilitate rapid advancement of successful drug candidates to patients.     

液压约束活塞发动机的流量脉动仿真分析

为研究间隙误差对液压约束活塞发动机流量脉动的影响,在ADAMS中建立其含有间隙误差的主运动系统动力学模型,将ADAMS中得到的模型数据导入AMESim中,建立液压系统模型。通过对比不同间隙误差模型的参数输出,分析间隙误差对系统流量脉动的影响。研究结果表明,在一定范围内,间隙误差对流量脉动有明显的影响,并随着间隙误差的增大而增加;而且,连杆大头和曲轴曲柄之间转动副径向间隙误差对系统流量脉动的影响最大。     

热轧层流辊道内冷辊回水结构的优化改进

针对某热轧厂1 580 mm生产线精轧出口层流辊道内冷辊频繁发生操作侧轴承失效问题,对其原因进行了分析,同时核算了内冷辊受热轴向膨胀后操作侧轴承侧向间隙。结果表明:操作侧轴承侧向间隙满足使用要求,轴承失效和辊筒受热膨胀无关;操作侧轴承失效的直接原因是轴套制造精度低导致骨架油封失效、内冷辊高速旋转“吸水”效应,使冷却回水进入轴承座内部,进一步造成润滑不良进而造成轴承失效。为此,对内冷辊回水结构进行了优化改进:在操作侧轴承座端盖和水套之间增加法兰,延长轴套及安装轴套的轴头,在轴头和轴套之间增加O型密封圈。改进后两年的使用周期内没有发生过轴承失效故障。     

KJS-Y系列矿用水动力降尘器的改进设计

针对当前KJS-Y系列降尘器效率低的问题,通过调整叶轮轴向间隙与径向间隙参数,分别对不同安装参数的降尘器进行数值模拟,通过数值模拟分析特定截面压力分布情况,确定了叶轮最佳安装参数,大大提高了降尘器的工作效率,同时降低了设计成本。     

A new high-pressure clearance seal with flexible laddered piston assembly in oil-free miniature compressor for potential hydrogen applications and investigation on its dynamic sealing efficiency

In this paper, a new flexible laddered piston assembly of clearance seal without any soft seal part was proposed for a long life time run of high-pressure stage in oil-free miniature compressor for potential hydrogen applications. In this assembly, the functions of radial load bearing and gas sealing were undertaken independently by large and small piston. The dynamic sealing performance evaluation was carried out by comprehensively considering the real-time variation of gas properties and piston motion with thermodynamic process in the compression chamber. Simulation study shows that the introduced clearance gap has a great influence on the expansion, compression and discharge process. Leakage through the clearance would lead to the in-cylinder pressure drop during the discharge process and bring about oscillation and earlier closure of the discharge valve. Sealing clearance exert more significant influence on the sealing efficiency in the high-pressure stage compared to sealing length and shaft speed.