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1.
为推进病历数字化发展,并确保其信息的安全性,将以HIS电子病历系统为基础,采用安信数字签名技术和PKI或PMI系统搭建相信并加以任用的授权服务,经过针对实际的PKC和CA的确认、委托与管控构建整体的数字签名平台,完成电子病历数字签名功能设计,以加强电子文件的完整性、真实性和不可抵赖性。最后以某医院的XML结构化的电子病历系统为基础进行项目实施,完成了医护人员通过HIS的快速身份认证,和准确地数字签名。  相似文献   
2.
Coxsackievirus A16 (CA16) is one of the major causative agents of hand, foot, and mouth disease (HFMD). Children aged <5 years are the most affected by CA16 HFMD globally. Although clinical symptoms of CA16 infections are usually mild, severe complications, such as aseptic meningitis or even death, have been recorded. Currently, no vaccine or antiviral therapy for CA16 infection exists. Single-chain variable fragment (scFv) antibodies significantly inhibit viral infection and could be a potential treatment for controlling the infection. In this study, scFv phage display libraries were constructed from splenocytes of a laying hen immunized with CA16-infected lysate. The pComb3X vector containing the scFv genes was introduced into ER2738 Escherichia coli and rescued by helper phages to express scFv molecules. After screening with five cycles of bio-panning, an effective scFv antibody showing favorable binding activity to proteins in CA16-infected lysate on ELISA plates was selected. Importantly, the selected scFv clone showed a neutralizing capability against the CA16 virus and cross-reacted with viral proteins in EV71-infected lysate. Intriguingly, polyclonal IgY antibody not only showed binding specificity against proteins in CA16-infected lysate but also showed significant neutralization activities. Nevertheless, IgY-binding protein did not cross-react with proteins in EV71-infected lysate. These results suggest that the IgY- and scFv-binding protein antibodies provide protection against CA16 viral infection in in vitro assays and may be potential candidates for treating CA16 infection in vulnerable young children.  相似文献   
3.
目的:探索CA724表达与新辅助化疗结合腹腔镜D2根治术治疗进展期胃癌疗效及预后的相关性。方法:回顾性分析我院2017年1月-2018年1月期间收治的局部进展期胃癌患者68例临床资料,根据治疗方案的不同分为对照组30例、研究组38例,对照组采取单纯腹腔镜D2根治术治疗,研究组在腹腔镜D2根治术的基础上结合新辅助化疗治疗,对比两组总有效率、预后情况、CA724表达水平以及阳性率差异,采用Spearman相关性分析法检验CA724水平与患者疗效及预后的关系。结果:研究组患者的总有效率(60.53%)高于对照组患者(43.33%),但差异无统计学意义(χ2=1.989,P=0.158);研究组患者的3年生存率(78.95%)明显高于对照组患者(56.67%),复发转移率(18.42%)则明显低于对照组患者(46.67%),差异有统计学意义(χ2=3.899、6.266,P=0.048、0.012);两组患者术后的CA724表达水平和阳性率均较本组治疗前明显下降,且研究组的下降幅度大于对照组(χ2/t=5.643、6.546,P<0.001);CA724的表达平与患者的疗效及三年生存率呈负相关(r=-0.625、-0.732和-0.832、-0.839,P均<0.001),与患者的复发、转移率呈正相关(r=0.662和0.873,P均<0.001)。结论:血清CA724的表达水平及阳性率变化可在一定程度上反映行新辅助化疗结合腹腔镜D2根治术治疗进展期胃癌患者的疗效及预后情况,当CA724的表达水平及阳性率较低时,提示患者的疗效及预后情况较好,具有一定的临床意义。  相似文献   
4.
以海藻酸钠(SA)、氯化钙、微米零价铁(MZVI)为原料,制备了海藻酸钙(CA)固定化MZVI填料(CAZ),通过静态烧杯实验和动态PRB模型实验,探讨了CA运用对Cr(Ⅵ)的去除性能的影响,并通过电镜扫描分析了CA避免团聚、堵塞机制。实验结果表明,CA凝胶颗粒的运用能显著提升MZVI的除Cr(Ⅵ)性能,CAZ相比MZVI对Cr(Ⅵ)的去除率和反应速率分别提升7.1倍、23.0倍;MZVI利用率的提高是CAZ反应器处理Cr(Ⅵ)水量显著大于MZVI反应器的主要原因,MZVI反应速率的提高是CAZ反应器出水Cr(Ⅵ)浓度显著低于MZVI反应器的主要原因。电镜扫描结果表明,SA与氯化钙交联形成的CA具有丰富的骨架孔道结构,具有骨架支撑作用,能有效克服MZVI颗粒因重力作用导致团聚、降低比表面积的缺陷。CA表层固定的MZVI颗粒与Cr(Ⅵ)反应生成的(FexCr1-x)(OH)3 络合沉淀会冲破CA表层外壳,释放到零价铁-渗透反应墙(Fe0-PRB)系统中,导致PRB反应初期出现堵塞现象;大部分MZVI颗粒被固定在CA内部,CA内部有较多孔隙结构,这些孔隙结构会控制(FexCr1-x)(OH)3 络合沉淀释放,从而缓解了Fe0-PRB后期长期运行持续堵塞的问题。  相似文献   
5.
Collaboration has been found in previous studies on the design of assembly lines to be a useful mechanism. In this study, the focus is on a collaborative assembly (CA) framework, inspired by the design principles of CCT, the Collaborative Control Theory, to improve balanceability and flexibility of assembly lines through tool sharing (TS) among idle and bottleneck workstations. TS is widely practiced in advanced assembly facilities to reduce cost and improve consistency and standardization in assembly and in assembly-and-test utilities, relying often on real time control. The framework developed here addresses the systems design aspect of Mechatronics, covering the planning, execution, and control mechanisms. Planning includes assembly line balancing (ALB) and initial TS decisions, made continually by solving a bi-objective mixed-integer program (BOMIP). A collaborative multi-agent system (CMAS) enhanced with a TS-best matching (BM) protocol is developed to execute the plan, control the process, and modify the TS decisions, considering dynamic changes in the system’s operations. Experiments show that the new CA framework significantly outperforms classic approaches (i.e., ALB without TS-BM) in terms of cycle time, utilization of tools, and balanceability. In addition, the control mechanism is proven to augment the line’s flexibility against the inherent uncertainties of assembly processes, compared to the previously developed static CA frameworks.  相似文献   
6.
周娟  葛万成  汪亮友  林佳燕 《通信技术》2015,48(9):1053-1057
以LTE-Advanced系统为研究背景,提出了一种基于动态频谱接入技术的载波聚合方案(DSA-CA)。该方案的主要思想是使支持载波聚合技术的eNB根据小区的平均负载自适应地调节聚合的载波数量,从而达到合理利用频谱的目的。通过对基于动态频谱接入技术的载波聚合方案在LTE-Advanced 系统中的性能进行仿真研究,结果表明:DSA-CA方案与传统载波聚合方案(CA)相比,可使系统性能在一定程度上得到提高,尤其当一个小区处于高负载、另一个小区处于低负载时,DSA-CA方案的优势更加明显,此时高负载小区系统吞吐量得到明显提高,低负载小区的频谱效率也显著上升。  相似文献   
7.
李俊  舒志兵 《机床与液压》2019,47(11):39-42
针对遗传算法在移动机器人路径规划中易产生早熟现象和收敛速度慢的问题,提出了改进的D~* Lite遗传算法。该算法将D~* Lite算法和遗传算法相结合,通过引入碰撞系数和可视检测技术以提高路径安全性,寻找最短路径。在遗传算法设计中加入动态调整交叉与变异概率,以解决算法在路径规划中因陷入局部最优值而不能到达目标点的问题。最后,通过实验仿真可知:与蚁群算法和免疫遗传算法相比,改进的D~* Lite遗传算法执行效率高,可以快速规划出全局最优路径。  相似文献   
8.
针对无线传感器网络(WSN)路由协议设计需首要解决的节能问题,提出一种将元胞自动机(CA)用于无线传感器网络的高效节能机制。该机制在路由层设置元胞处理模块,通过路由报文捎带CA信息网络节点自组织形成以sink节点为中心的多级元胞自动机区域,决策节点根据通信过程中携带的元胞信息切换传感节点的工作状态以实现节能。仿真结果验证了该机制能降低网络整体能量消耗,提高能量利用率,延长整个网络生存周期。  相似文献   
9.
IEEE 802.11 wireless network standard has become one of the most used wireless networking technologies for smart devices as it offers mobility support and low cost deployment. However, these devices deeply rely on the energy provided by their batteries, which results in limited running time. IEEE 802.11 network standard provides stations with carrier sense multiple access with collision avoidance for the medium access. Yet it results in stations to consume an important amount of power. Therefore, minimizing WiFi‐based energy consumption in smart devices has been received substantial attention in both academia and industry. Accordingly, this paper * proposes a novel beacon‐based energy‐efficient collision‐free medium access control protocol for any type of IEEE 802.11 stations, regardless of being stationary or mobile, or having different amount of traffic flow, transmission rates, or traffic types. The proposed scheme is valid for all types of low or wide bandwidth, single or multiuser multiple‐input multiple‐output WLAN channels, such as IEEE 802.11a\b\g\n\ac. In the proposed scheme, energy saving is achieved, enabling stations to transmit on the right time and maintaining stations in the doze state during a predetermined sleep_time interval after each successful frame transmission, by making use of modified control and management frames of the standard IEEE 802.11 protocol. The proposed scheme reduces the probability of collisions and may allow stations to enter the collision‐free state, regardless of the number of stations on the channel and their traffic types. Widespread simulations have been executed to validate the efficiency of the proposed method. The results demonstrate that the proposed method significantly increases overall throughput and reduces power consumption of stations over IEEE 802.11 WLANs.  相似文献   
10.
Selective Laser Melting (SLM) was used to process a powder mixture of CP Ti, 6.5 wt% Mo and 3.5 wt% Mo2C. The process parameters were optimized to obtain full-density, crack free parts. After the in situ decomposition of Mo2C in favor of the formation of TiC, the material consisted of a homogeneous dispersion of submicrometer sized TiC platelets in a β-(Ti,Mo) matrix exhibiting a high hardness up to 550 HV and compressive yield stress of 1164 ± 37 MPa. The microstructure and mechanical properties could be tailored by variation of the process parameters within the high-density processing window, as well as through post-process heat treatments.  相似文献   
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