Preparation and Evaluation of a Self-Nanoemulsifying Drug Delivery System Loaded with Heparin Phospholipid Complex

A self-nanoemulsifying drug delivery system (SNEDDS) was developed to enhance the absorption of heparin after oral administration, in which heparin was compounded with phospholipids to achieve better fat solubility in the form of heparin-phospholipid (HEP-Pc) complex. HEP-Pc complex was prepared using the solvent evaporation method, which increased the solubility of heparin in n-octanol. The successful preparation of HEP-Pc complex was confirmed by differential scanning calorimetry (DSC), Fourier-transform infrared (FT-IR) spectroscopy, NMR, and SEM. A heparin lipid microemulsion (HEP-LM) was prepared by high-pressure homogenization and characterized. HEP-LM can enhance the absorption of heparin after oral administration, significantly prolong activated partial thromboplastin time (APTT) and thrombin time (TT) in mice, and reduce fibrinogen (FIB) content. All these outcomes indicate that HEP-LM has great potential as an oral heparin formulation.     

建筑工业化发展的多群体演化博弈与仿真研究

新型建筑工业化具有高质量、低消耗、可循环发展等特征，其推广已上升到国家战略层面。利用演化博弈方法，建立“政府-开发商-银行” 的三方动态演化博弈模型，进行各博弈主体策略的演化稳定性分析，并针对初始状态、奖惩力度、借贷风险和开发成本等对演化结果的影响进行动态仿真。在此基础上， 考虑开发商群体的网络拓扑特征对演化真实性的影响，引入复杂网络理论， 以无标度网络为载体描述开发商个体的连接偏好和决策机制，构建政府监管下的建筑工业化扩散模型，并通过仿真深入研究相关因素对扩散深度的影响作用，最后结合仿真结果给出相应对策建议。     

基于蜻蜓翅脉结构的连续碳纤维增强树脂基复合材料仿生设计与增材制造

以具有轻质高强优异性能的蜻蜓翅脉结构为设计灵感，在分析翅脉网格结构抗冲击原理的基础上，设计了传统和仿生两类对比结构。采用熔融挤出3D打印机成功制备了具有不同结构的连续碳纤维增强聚乳酸复合材料试样，并对不同结构复合材料试样的拉伸性能和抗冲击性能进行了测试和对比分析。研究分析结果表明：由于拉伸力方向上的连续碳纤维含量相对较少，限制了仿生结构复合材料抗拉强度的提高，但仿生结构的平均抗拉强度为传统结构的1.18倍；当仿生结构复合材料试样受到冲击力时，其内部六边形结构的连接角度会发生变化，从而极大消耗冲击能量，同时具有六边形网格结构的连续碳纤维可以有效阻碍裂纹的扩展，因此仿生结构的平均冲击韧性可以达到传统结构的2.46倍；仿生蜻蜓翅脉结构可以显著提高增材制造复合材料的综合力学性能，且对于抗冲击性能的提高具体突出效果。连续碳纤维增强树脂基复合材料的有效可行的仿生蜻蜓翅脉结构设计和增材制造，可极大扩展其在高冲击载荷领域中的相应应用。     

某铁矿强磁尾矿反浮选回收试验研究

针对我国西部某铁矿强磁选尾矿进行了反浮选回收铁资源的试验研究, 探讨了pH值、抑制剂可溶性淀粉用量、阳离子捕收剂十二胺用量对浮选指标的影响。结果表明, 在矿浆pH=10、可溶性淀粉用量2 400 g/t、十二胺用量400 g/t条件下进行一粗一精(精选药剂用量减半)闭路反浮选, 可获得铁品位43.88%、回收率50.93%的铁精矿产品。     

Gluten-free cakes with walnut flour: a technological,sensory, and microstructural approach

Walnut flour (WF), a by-product of walnut oil production, is characterised by high polyunsaturated fatty acids, proteins, and fibre contents and presents suitability for bakery products. However, when using non-traditional ingredients, it is essential to evaluate the effect on the quality properties of the final product. So, this work aimed to assess the impact of WF on the technological, physicochemical, and sensory properties of gluten-free (GF) cakes. WF was added at a flour blend (cassava (CS) and maize (MS) starches and rice flour) at 0, 10%, 15%, and 20%. The results showed that WF modified starch gelatinisation, increased amylose–lipid complex (ALC) content, and made crumbs easier to chew. Besides, the total dietary fibre (TDF) and protein content significantly increased. Cakes with 15% WF presented the highest specific volume (SV) and no differences in overall acceptability with respect to control. Hence, WF is a suitable ingredient for gluten-free bakery products.     

Chemically complex intermetallic alloys: A new frontier for innovative structural materials

Intermetallic materials are bestowed by diverse ordered superlattice structures together with many unusual properties. In particular, the advent of chemically complex intermetallic alloys (CCIMAs) has received considerable attention in recent years and offers a new paradigm to develop novel metallic materials for advanced structural applications. These newly emerged CCIMAs exhibit synergistic modulations of structural and chemical features, such as self-assembled long-range close-packed ordering, complex sublattice occupancy, and interfacial disordered nanoscale layer, potentially allowing for superb physical and mechanical properties that are unmatched in conventional metallic materials. In this paper, we critically review the historical developments and recent advances in ordered intermetallic materials from the simple binary to chemically complex alloy systems. We are focused on the unique multicomponent superlattice microstructures, nanoscale grain-boundary segregation, and disordering, as well as the various extraordinary mechanical and functional properties of these newly developed CCIMAs. Finally, perspectives on the future research orientation, challenges, and opportunities of this new frontier are provided.     

An infinite chain, {[Ni(tn)2]3[Fe(CN)4(μ-CN)2]2}n,a new catalyst for electrochemical-driven water splitting and photochemical-driven hydrogen evolution from water under blue light

A new catalyst for both water reduction and oxidation, based on an infinite chain, {[Ni(tn)₂]₃ [Fe(CN)₄ (μ-CN)₂]₂}_n, is formed by the reaction of NiCl₂, 1,3-propanediamine (tn) and K₃ [Fe(CN)₆]. {[Ni(tn)₂]₃ [Fe(CN)₄ (μ-CN)₂]₂}_n can electro-catalyze hydrogen evolution from a neutral aqueous buffer (pH 7.0) with a turnover frequency (TOF) of 1561 mol of hydrogen per mole of catalyst per hour (H₂/mol catalyst/h) at an overpotential (OP) of 837 mV {[Ni(tn)₂]₃ [Fe(CN)₄ (μ-CN)₂]₂}_n also can electro-catalyze O₂ production from water with a TOF of ～45 mol O₂ (mol cat)^?1s^?1 at an OP of 591 mV. Under blue light (λ = 469 nm), together with CdS nanorods (CdS NRs) as a photosensitizer, and ascorbic acid (H₂A) as a sacrificial electron donor, {[Ni(tn)₂]₃ [Fe(CN)₄ (μ-CN)₂]₂}_n can photo-catalyze hydrogen generation from an aqueous buffer (pH 4.0) with a turnover number (TON) of 11,450 mol H₂ per mole of catalyst (mol of H₂ (mol of cat)^?1) during 10 h irradiation. The average of apparent quantum yield (AQY) is as high as 40.96% during 10 h irradiation. Studies indicate that {[Ni(tn)₂]₃ [Fe(CN)₄ (μ-CN)₂]₂}_n exists in two forms: a cyano-bridged chain ({[Ni(tn)₂]₃ [Fe(CN)₄ (μ-CN)₂]₂}_n) in solid, and a salt ([Ni(tn)₂]₃ [Fe(CN)₆]₂) in aqueous media; Catalytic reaction occurs on the nickel center of [Ni(tn)₂]²⁺, and the introduction of [Fe(CN)₆]^3- can improve the catalytic efficiency of [Ni(tn)₂]²⁺ for H₂ or O₂ generation. We hope these findings can afford a new method for the design of catalysts for both water reduction and oxidation.     

Predetermination of potential plastic hinges on reinforced concrete frames using GFRP reinforcement

In the past, glass fiber-reinforced polymer (GFRP)-reinforcement has been successfully applied in reinforced concrete (RC) structures where corrosion resistance, electromagnetic neutrality, or cuttability were required. Previous investigations suggest that the application of GFRP in RC structures could be advantageous in areas with seismic activity due to their high deformability and strength. However, especially the low modulus of elasticity of GFRP limited its wide application as GFRP-reinforced members usually exhibit considerably larger deformations under service loads than comparable steel-reinforced elements. To overcome the aforementioned issues, the combination of steel and GFRP reinforcement in hybrid RC sections has been investigated in the past. Based on this idea, this paper presents a novel concept for the predetermination of potential plastic hinges in RC frames using GFRP reinforcement. To analyze the efficiency of the concept, nonlinear finite element simulations were performed. The results underscore the high efficiency of hybrid steel-GFRP RC sections for predetermining potential plastic hinges on RC frames. The results also indicate that the overall seismic behavior of RC structures could be improved by means of GFRP as both the column base shear force during the seismic activity as well as the plastic deformations after the earthquake were considerably less pronounced than in the steel-reinforced reference structure.     

电荷调节剂的研究现状与进展

电荷调节剂（charge control agent，CCA）作为一种重要的改变墨粉带电特性与起电速率的添加剂，逐渐受到研究者们越来越多的重视。本文针对目前墨粉所用的几类传统电荷调节剂的发展历程进行了总结。文中指出按照电性的不同，CCA可分为正电性与负电性两大类。在传统CCA中，正电性CCA包括苯胺黑类与季铵盐类，前者由于本身具有颜色无法应用到彩色打印中，而季铵盐类因其合成简单、色彩较浅等优势是目前使用最多的正电性CCA。负电性CCA包括偶氮金属络合物类与叔丁基水杨酸金属络合物类，其中后者因其带电量稳定、在树脂中分散性好且无色的优点成为目前应用最广泛的传统CCA。近年来，金属络合物型CCA由于在高温状态下不稳定的缺点使结构中不含金属离子的新型CCA成为研究的热点。此外，由于对环境无害及高画质的要求提高，生物基材料型CCA与通过聚合反应合成的CCA应用也越来越普及。在世界范围内，日本的东方化学工业株式会社、保土谷化学工业株式会社与中国湖北鼎龙化学股份有限公司是最大的3个CCA生产商，而前两家公司目前占据全球80%以上的份额，因此研究发展高端显像信息化学品仍然是我国墨粉行业的重要任务。文章针对未来如何解决不含金属离子的电荷调节剂合成成本过高的问题，指出发展更具价格竞争力、带电性能充分、对环境无害、面向彩色打印的无色电荷调节剂将成为电荷调节剂发展的新趋势。     

基于改进LFM算法的主动解列断面搜索方法

针对传统解列断面算法复杂度高的问题,提出一种基于改进LFM算法的解列断面搜索方式。首先,基于节点间电气联系和能量转移分布熵完成电网加权复杂网络建模;其次,基于主动解列断面约束条件,对LFM算法做适应性改良;最后,通过改进LFM算法得到解列断面,并在IEEE39节点系统中验证了算法有效性。仿真结果表明,改进LFM算法可充分考虑传统解列断面的约束条件,在算法具有较低复杂度的同时对系统运行状态更强的适应性。