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1.
L.J. Espinoza-Pérez S. Esquivel-Medina E. López-Honorato 《Ceramics International》2021,47(11):15527-15532
The influence of the microstructure on the corrosion rate of three monolithic SiC samples in FLiNaK salt at 900 °C for 250 h was studied. The SiC samples, labeled as SiC-1, SiC-2, and SiC-3, had corrosion rates of 0.137, 0.020, and 0.043 mg/cm2h, respectively. Compared with grain size and the presence of special grain boundaries (i.e., Σ3), the content of high-angle grain boundaries (HAGBs) appeared to have the strongest influence on the corrosion rate of SiC in FLiNaK salt, since the corrosion rate increased six times as the concentration of high-angle grain boundaries increased from 19 to 32% for SiC-2 and SiC-1, respectively. These results stress the importance of controlling the content of HAGBs during the production process of SiC. 相似文献
2.
Olga Azevedo Filipa Cordeiro Miguel Fernandes Gago Gabriel Miltenberger-Miltenyi Catarina Ferreira Nuno Sousa Damio Cunha 《International journal of molecular sciences》2021,22(9)
Fabry disease (FD) is an X-linked lysosomal storage disorder caused by mutations of the GLA gene that result in a deficiency of the enzymatic activity of α-galactosidase A and consequent accumulation of glycosphingolipids in body fluids and lysosomes of the cells throughout the body. GB3 accumulation occurs in virtually all cardiac cells (cardiomyocytes, conduction system cells, fibroblasts, and endothelial and smooth muscle vascular cells), ultimately leading to ventricular hypertrophy and fibrosis, heart failure, valve disease, angina, dysrhythmias, cardiac conduction abnormalities, and sudden death. Despite available therapies and supportive treatment, cardiac involvement carries a major prognostic impact, representing the main cause of death in FD. In the last years, knowledge has substantially evolved on the pathophysiological mechanisms leading to cardiac damage, the natural history of cardiac manifestations, the late-onset phenotypes with predominant cardiac involvement, the early markers of cardiac damage, the role of multimodality cardiac imaging on the diagnosis, management and follow-up of Fabry patients, and the cardiac efficacy of available therapies. Herein, we provide a comprehensive and integrated review on the cardiac involvement of FD, at the pathophysiological, anatomopathological, laboratory, imaging, and clinical levels, as well as on the diagnosis and management of cardiac manifestations, their supportive treatment, and the cardiac efficacy of specific therapies, such as enzyme replacement therapy and migalastat. 相似文献
3.
基于PFC3D的北京砂卵石地层盾构刀盘选型及刀具布置数值模拟研究 总被引:1,自引:0,他引:1
砂卵石地层是一种典型的力学不稳定地层及强磨蚀性地层,盾构在该类地层中掘进通常会面临刀盘、刀具磨损严重,盾构推力与刀盘扭矩偏高且波动幅度大、地层变形不易控制等问题。砂卵石地层盾构掘进效率的高低及地层控制的好坏,刀盘选型及刀具配置是关键。以北京地铁新机场线“磁各庄站~1#风井”盾构区间为工程依托,利用PFC3D数值模拟及现场测试相结合的手段,研究刀盘开口率、刀具组合高差、先行刀刀间距等参数对盾构掘进效率及地层变形的影响。研究结果表明:相同掘进参数下大开口率辐条式刀盘比小开口率辐板式刀盘具有更好的掘进速度,小开口率辐板式刀盘掘进时引起的地表变形更小,对周围地层的扰动范围也更小;先行刀与切削刀的组合高差为70 mm时盾构掘进效率较高且扭矩较低;先行刀刀间距设定为300 mm时,盾构有较好的掘进效率和较低的刀盘扭矩。工程实践表明;要实现砂卵石地层盾构长距离高效掘进,大开口率辐条式刀盘设计及大高差梯次化刀具布置是基础,高贯入度、低转速的掘进控制是关键。研究结果可为类似工程的盾构刀盘选型与刀具布设提供借鉴。 相似文献
4.
在电力信息化战略的不断深入下,电力巡检机器人日益普及,为完善机器人功能,拓宽其应用前景,提出一种挂空异物智能检测方法。根据光照强度、天气状况等因素,基于不同颜色空间变量值与背景特征关联,合理利用对应滤波方式去除图像内噪声杂质。面向模糊不清的采集图像,依据前景与背景的分割阈值和平均灰度值,改变分段区间与拉伸区间,增强图像对比度。结合输电线路的直线特征与点线对偶特性,以霍夫变换直线提取法为基础识别出输电线路;通过设计的拟合恢复方法,获取完整的输电线路由局部二值模式图像特征点匹配策略,建立矩形兴趣范围,遍历像素点,检测出线路上的挂空异物。实验环节分别通过检测图像与评估指标数据,从主客观角度全面分析了检测效果,经实验结果验证,所提方法具有良好的可行性与适用性,能够较为准确地检测出多种异物。 相似文献
5.
Spindle speed variation (SSV) is one of the effective methods which suppresses regenerative chatter. However, regenerative chatter can grow even if SSV is applied. In the previous work, the chatter growth characteristics in SSV were clarified. The chatter frequency changes proportionally to the varying spindle speed, and it causes the change of the magnitude of the dynamic compliance. Hence, chatter can be suppressed through SSV since the dynamic compliance usually reduces as the chatter frequency changes. A greater compliance reduction can be obtained by a higher rate of spindle speeds in two consecutive revolutions at the same angular position, i.e., acceleration rate. From the investigations in the previous work, limitation of the conventionally utilized SSV profiles is found as follows: the acceleration rate always fluctuates with speed variation and the chatter vibration grows where the acceleration rate is insufficient for suppression, and hence suppressing chatter in all sections of SSV is difficult. In this paper, a new SSV profile with a constant acceleration rate, namely CAR-SSV, is proposed to overcome the limitation of chatter stability improvement by utilizing conventional SSV profiles. The magnitude of the acceleration rate is kept constant to realize the chatter suppression effect throughout the cutting process. Through time-domain simulation and cutting experiments, the chatter stability of CAR-SSV is investigated based on the previously introduced chatter stability evaluation indices. Influence of the parameters of CAR-SSV on the stability is investigated, and an appropriate strategy for setting SSV parameters to achieve higher stability is discussed. In addition, in order to verify the effectiveness of the proposed profile, the stabilities of conventional SSV profiles and CAR-SSV are compared through time-domain simulations and cutting experiments. 相似文献
6.
7.
Guglielmina Chimienti Anna Picca Flavio Fracasso Francesco Russo Antonella Orlando Giuseppe Riezzo Christiaan Leeuwenburgh Vito Pesce Angela Maria Serena Lezza 《International journal of molecular sciences》2021,22(4)
Calorie restriction (CR) is the most efficacious treatment to delay the onset of age-related changes such as mitochondrial dysfunction. However, the sensitivity of mitochondrial markers to CR and the age-related boundaries of CR efficacy are not fully elucidated. We used liver samples from ad libitum-fed (AL) rats divided in: 18-month-old (AL-18), 28-month-old (AL-28), and 32-month-old (AL-32) groups, and from CR-treated (CR) 28-month-old (CR-28) and 32-month-old (CR-32) counterparts to assay the effect of CR on several mitochondrial markers. The age-related decreases in citrate synthase activity, in TFAM, MFN2, and DRP1 protein amounts and in the mtDNA content in the AL-28 group were prevented in CR-28 counterparts. Accordingly, CR reduced oxidative mtDNA damage assessed through the incidence of oxidized purines at specific mtDNA regions in CR-28 animals. These findings support the anti-aging effect of CR up to 28 months. Conversely, the protein amounts of LonP1, Cyt c, OGG1, and APE1 and the 4.8 Kb mtDNA deletion content were not affected in CR-28 rats. The absence of significant differences between the AL-32 values and the CR-32 counterparts suggests an age-related boundary of CR efficacy at this age. However, this only partially curtails the CR benefits in counteracting the generalized aging decline and the related mitochondrial involvement. 相似文献
8.
Tao TIAN Chao-lan ZHANG Feng ZHU Shan-xin YUAN Ying GUO Sheng-guo XUE 《中国有色金属学会会刊》2021,31(5):1484-1495
A column experiment was conducted to investigate the effect of phosphogypsum (PG) on the saline- alkalinity, and aggregate stability of bauxite residue. Results showed that: with increasing leaching time, the concentrations of saline-alkali ions decreased while the concentration increased in bauxite residue leachate; compared with CK (control group) treatment, pH, electric conductivity (EC), exchangeable sodium percentage (ESP), sodium absorption ratio (SAR), and exchangeable Na+ content of bauxite residue were reduced following PG treatment; average particle sizes in aggregates following CK and PG treatments were determined to be 155 and 193 nm, respectively. SR-μCT test results also confirmed that bauxite residue following PG treatment acquired larger aggregates and larger pore diameter. These results indicate that the PG treatment could significantly modulate the saline-alkalinity, and simultaneously enhance aggregate stability of bauxite residue, which provides a facile approach to reclaim bauxite residue disposal areas. 相似文献
9.
对航天用紧固件TC4钛合金棒材进行固溶时效处理,对棒材不同位置进行显微组织观察、硬度和室温拉伸性能检测。结果表明:TC4钛合金棒材经固溶时效后表面至心部的组织与性能受冷却速度的影响呈现显著差异。固溶时效后的显微组织由稳定的等轴α相、弥散的马氏体α′相和亚稳定β相组成,试样端面上因冷却速度相差不大,次生α相的形态和含量没有明显差异;中部截面上边部至心部的次生α相含量逐渐增多,同时次生α相片层厚度逐渐增大并趋于等轴化。端面上不同位置显微硬度值没有明显差异,但中部截面上由边部至心部的显微硬度值呈总体降低趋势,且中部截面上边部的显微硬度值与端面相差不大。试样心部因固溶过程中冷却缓慢,整体试样的室温拉伸性能明显低于去除心部的试样。 相似文献
10.
在GB/T 228征求意见稿中规定了方法A和方法B速率控制模式,主要分为基于引伸计反馈的应变速率控制,以及根据平行长度估计的应变速率,即通过控制平行长度与需要的应变速率相乘得到的横梁分离速率。采用GB/T 228新标准中规定的不同速率控制模式对连续屈服和不连续屈服试样材料屈服强度(规定塑性延伸强度)进行试验,探讨了不同速率控制模式对于材料屈服强度的影响。结果发现,对于连续屈服试样采用应变速率控制和估计的平行长度应变速率控制,其性能指标未见明显差异。不连续屈服试样当无需ReH时,可以采用应变速率控制或估计的平行长度应变速率控制。当需要ReH时,应采用估计的平行长度应变速率控制。 相似文献