中国传统纺织服饰图案研究述评及价值阐释

目的 了解近年来传统纺织服饰图案的研究动态及发展趋势，归纳学术研究成果并进行评价，总结研究传统服饰图案的意义和对现代设计的启示。方法 基于史论视角、社会文化视角、工艺美术视角和设计艺术视角梳理相关文献，结合现有研究分析中国传统服饰图案的资料来源及其特色、传统服饰图案的研究热点、新时代传统服饰图案的生存策略及中国传统服饰图案创新设计的应用领域。结果指出传统服饰图案的研究史料取材丰富、研究类型呈现多元；当前传统服饰图案的传承与创新体现了数字化发展、美育引导、政策支持的特点；传统服饰图案在服装设计、公共空间、文创产品中大放异彩。结论 中国传统纺织服饰图案研究多点开花，但缺乏系统整体的“中国传统纺织服饰图案知识谱系”用于指导相关研究和实践，对中国传统纺织服饰图案的研究多处于实证分析的层面且欠缺深入独到的理论，通过综述与价值阐述，提出研究的不足之处，纵深学术研究，同时为中国传统纺织服饰图案的现代设计提供新思路。     

[2.2]Paracyclophane-Based TCN-201 Analogs as GluN2A-Selective NMDA Receptor Antagonists

Recent studies have shown the involvement of GluN2A subunit-containing NMDA receptors in various neurological and pathological disorders. In the X-ray crystal structure, TCN-201 ( 1 ) and analogous pyrazine derivatives 2 and 3 adopt a U-shape (hairpin) conformation within the binding site formed by the ligand binding domains of the GluN1 and GluN2A subunits. In order to mimic the resulting π/π-interactions of two aromatic rings in the binding site, a [2.2]paracyclophane system was designed to lock these aromatic rings in a parallel orientation. Acylation of [2.2]paracyclophane ( 5 ) with oxalyl chloride and chloroacetyl chloride and subsequent transformations led to the oxalamide 7 , triazole 10 and benzamides 12 . The GluN2A inhibitory activities of the paracyclophane derivatives were tested with two-electrode voltage clamp electrophysiology using Xenopus laevis oocytes expressing selectively functional NMDA receptors with GluN2A subunit. The o-iodobenzamide 12 b with the highest similarity to TCN-201 showed the highest GuN2A inhibitory activity of this series of compounds. At a concentration of 10 μM, 12 b reached 36 % of the inhibitory activity of TCN-201 ( 1 ). This result indicates that the [2.2]paracyclophane system is well accepted by the TCN-201 binding site.     

Discovery of New Antiproliferative Imidazopyrazole Acylhydrazones Able To Interact with Microtubule Systems

Even though immunotherapy has radically changed the search for anticancer therapies, there are still many different pathways that are open to intervention with traditional small molecules. To expand our investigation in the anticancer field, we report here a new series of compounds in which our previous pyrazole and imidazopyrazole scaffolds are linked to a differently decorated phenyl ring through an acylhydrazone linker. Preliminary tests on the library were performed at the National Cancer Institute (USA) against the full NCI 60 cell panel. The best compounds among the imidazopyrazole series were then tested by immunofluorescence staining for their inhibition of cell proliferation, apoptosis induction, and their effect on the cell cycle and on microtubules. Two compounds, in particular 4-benzyloxy-3-methoxybenzyliden imidazopyrazole-7-carbohydrazide showed good growth inhibition, with IC₅₀ values in the low-micromolar range, and induced apoptosis. Both compounds altered the cell-cycle phases with the appearance of polyploid cells. Immunofluorescence analysis evidenced microtubules alterations; tubulin polymerization assays and docking studies suggested the tubulin system to be the possible, although not exclusive, target of the new acylhydrazone series reported here.     

Advanced Functional Materials Constructed from Pillar[n]arenes

Pillar[n]arenes are new generation of supramolecular macrocyclic host, which exhibit excellent host−guest recognition properties. In the last decade, functional materials constructed from pillar[n]arenes have been attracted more and more attention and displayed outstanding characteristics, such as stimuli-responsiveness, self-healing and adaptability. In this mini-review, we provide a survey of the pillar[n]arene-based literatures covering light-harvesting systems, functional hydrogels, and solid materials. It is anticipated that more and more pillar[n]arenes-based advanced materials with multi-functional properties will appear in the near future.     

2-L-天冬氨酸-2-脱氧-D-葡萄糖的合成及热裂解分析

以D-果糖和L-天冬氨酸单钾盐为原料合成了2-L-天冬氨酸-2-脱氧-D-葡萄糖，利用傅里叶变换红外光谱、 1H核磁共振（nuclear magnetic resonance，NMR）、13C NMR和高分辨率质谱技术进行结构表征。应用热重-微商 热重和在线裂解气相色谱/质谱联用技术分别研究了2-L-天冬氨酸-2-脱氧-D-葡萄糖的热失重和热裂解行为。采用 1,1-二苯基-2-三硝基苯肼（1-diphenyl-2-picrylhydrazyl，DPPH）自由基清除法和还原能力法对其体外抗氧化活性进 行测定。结果表明：合成产物为目标化合物；目标化合物的裂解温度为187.8 ℃，700 ℃时总失重达到91.26%；目 标化合物裂解产物的数量随温度的升高而增多，裂解产物包括杂环类、酮类、羧酸类、醛类、酚类、烯烃类、醇类 和芳烃类等化合物，裂解产物表现出烘焙香、甜香、焦甜香、可可香、花香和奶香等香韵；目标产物具有较强的 DPPH自由基清除能力和还原能力，是一种潜在的抗氧化剂。     

Potential Applications of Cucurbit[n]urils Inclusion Complexes in Photodynamic Therapy

Cucurbit[n]urils (CB[n]s) have emerged as potential candidates for drug delivery in several areas due to their strong binding interactions and low toxicity. More recently, their benefits for a type of cancer treatment termed Photodynamic Therapy (PDT) have been recognized. The outcomes of this therapy rely on better drug delivery strategies and improving overall photoactivity of the drugs, which is where CB[n]s could have a strong impact. The effects of these molecular containers on photoactivity are discussed and new interesting work is highlighted.     

Fabrication of fine-grained α/β Si3N4 by Hot Pressing Flowing Sintering at 1550 °C

In this paper, Hot Pressing Flowing Sintering (HPFS) was successfully applied to the consolidation of silicon nitride ceramics at low sintering temperature. Fine-grained α/β-Si₃N₄ with high density was fabricated by HPFS at 1550 °C. The low temperature densification process was based on the hot pressing flow enhanced particle rearrangement mechanism. The shear stress which generated in the flowing process helped enhance the particle rearrangement with the lubrication of the liquid phase, which lead to collapse of the pores. The densification process was finished with minimum grain growth. Meanwhile, the rod-like β-Si₃N₄ nuclei was textured during the flowing process. The (101)/(210) ratio of β-Si₃N₄ was 0.09 on the plane perpendicular to the hot-pressing direction. The Vickers hardness and flexural strength of the sintered sample was 19.59 ± 0.36 GPa and 1022 ± 138 MPa, respectively.     

基于k-shell的复杂网络最短路径近似算法

复杂网络最短路径经典算法的处理效率较低，不适用于大规模复杂网络，而现有近似算法通用性有限，且计算准确率不理想，不能满足规模日益扩大的复杂网络中的最短路径计算需求。针对于此，提出基于[k]-shell的复杂网络最短路径近似算法。算法利用节点的[k]-shell值进行网络划分并引导搜索路径，利用超点聚合处理[k]-shell子网来降低路径搜索中节点和连边的规模，通过在路径搜索过程使用双向搜索树方法提高算法的计算效率和准确率。实验结果表明，算法通用性较好，在现实与仿真大规模复杂网络中均具有较高的计算效率和准确率。