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1.
目的:探讨长春西汀对七氟醚麻醉对幼鼠远期学习与记忆功能的影响及机制。方法:60只SD幼鼠,随机分为对照组、麻醉组、长春西汀低剂量组(5 mg/kg)、长春西汀高剂量组(10 mg/kg)和GSK3β抑制剂组(10 mg/kg),每组12只。麻醉前2 h,各组幼鼠腹腔注射对应剂量药物。除对照组,各组持续吸入4%七氟醚4 h。8周后开始水迷宫实验,应用免疫荧光双染检测幼鼠脑中神经元增殖,Western blot检测海马组织中各蛋白表达。结果:训练初期各组幼鼠潜伏期没有统计学差异,第三天训练中,与对照组相比,麻醉组幼鼠到达平台潜伏期显著增加(P<0.05);第四天训练中,与麻醉组相比,长春西汀与SB216763干预显著减少了幼鼠到达平台潜伏期(P<0.05)。且测试中,与麻醉组相比,10 mg/kg长春西汀与SB216763干预幼鼠首次达到平台潜伏期显著减少(P<0.05),穿越平台次数显著增加(P<0.05)。与此同时,七氟醚麻醉介导了幼鼠BrdU/NeuN阳性细胞数显著减少(P<0.05)。此外,七氟醚介导海马中Wnt3a表达降低、p-GSK3β表达增加、β-catenin表达降低(P<0.05)。而长春西汀与SB216763干预显著逆转了这些细胞与蛋白表达。 结论:长春西汀通过Wnt/GSK3β/β-catenin信号通路改善七氟醚麻醉诱导幼鼠远期学习记忆功能。 相似文献
2.
《Ceramics International》2021,47(18):25863-25874
The inherent brittleness of bioceramics restricts their applications in load-bearing implant, although they possess good biocompatibility and bioactivity. ZnO, MgO and 58S bioglass (BG) were incorporated as additives to further improve the mechanical properties and biocompatibility of β-TCP and ZnO/MgO/BG-β-TCP composite scaffolds were manufactured via digital light processing (DLP). The composite with the best comprehensive performance was selected for degradation behavior and biocompatibility evaluation. The effects of different proportions of ZnO/MgO/BG on mechanical strength were analyzed and ZnO0·5/MgO1/BG2-β-TCP (ZMBT) samples exhibited superior mechanical strength. The improvement by 272% and 99% respectively was achieved in fracture toughness and compressive strength with the optimal recipe. The enhancement effect is realized through phase transition, alterative sliding actions and transgranular fracture to effectively prevent the load transfer combining the functions of bioglass and metal oxide. ZMBT scaffolds exhibited a more desirable pH environment and an enhanced ability of apatite-mineralization formation, meanwhile Si4+, Mg2+ and Zn2+ were gradually released from scaffolds. Furthermore, in vitro evaluation indicated that ZMBT scaffolds presented not only excellent cell attachment, proliferation, alkaline phosphatase (ALP) activity, but they up-regulated osteogenic gene (ALP, OCN, Runx2). These results suggest that the addition of ZnO/MgO/BG to DLP-printed β-TCP scaffolds offer a smart strategy to fabricate porous scaffolds with conspicuously better biological and physicochemical properties including compressive strength, bioactivity, osteogenesis and osteogenesis-related gene expression. Metal-oxide and BG synergistically enhanced the mechanical and biological properties which make the ZMBT scaffolds a strong candidate for bone repair applications. 相似文献
3.
Ning Wang Jun Chen Qi Zhou Lianzhou Jiang Liqi Wang Yingjie Dai Dianyu Yu Walid Elfalleh 《European Journal of Lipid Science and Technology》2021,123(6):2000091
Crude wax extracted from rice bran oil (RBO) is used to improve the oleogel properties and oxidative stability of RBO. The effect of crude rice bran wax (CrBW) on the formation characteristics and oxidative stability of oleogels is discussed. The results show that oleogels can be formed with 7.0 wt% CrBW at 20 °C. As the concentration of CrBW increases from 7.0 to 11.0 wt%, the hardness and solid fat content (SFC) of the oleogels increase significantly, and the oleogels are primarily β' crystals. Moreover, oleogel crystals formed with 5 and 7 wt% CrBW are flocculent; when the amount included is 9%, the oleogel crystals are transformed into long dendrites, and the density rises. After 90 days of storage at 20 °C, the peroxide value of oleogels formed with 9.0 wt% CrBW slowly rises from 3.21 to 6.52 mmol kg−1. Practical Applications: Oleogels prepared here by CrBW and RBO are an innovative structural lipid without trans fats. Useful information on the rich fats and nutrients in CrBW is provided, which reduces the production cost and improves the industrial production capacity. 相似文献
4.
Styrene-butadiene-styrene (SBS) modified asphalt (SMA) has been widely used in road engineering for decade. However, the phase separation of SMA was obvious during the transport and SBS degraded after aging. To resolve these problems, β-cyclodextrin (β-CD) was used to modify SMA in this work. Conventional properties, storage stability, the effect of short-term aging on the morphology, and rheological property for SMA and β-CD/SMA were investigated. The softening point of modified asphalt reached to the maximum of 66.7°C when 1 wt% β-CD was added to SMA, where the penetration had shown the minimum of 80.8 dmm. In addition, the ductility of β-CD/SMA increased to the maximum of 797 mm when the content of β-CD was increased to 5 wt%. Furthermore, incorporation of β-CD improved the storage stability of SMA. Importantly, the aggregation of SBS was observed in β-CD/SMA, but modifiers distributed uniformly after a short-term aging. The rutting resistance and antiaging performances of SMA were also improved by the addition of β-CD. Considering the comprehensive properties of modified asphalt, the optimum content of β-CD was found to be 2 wt%. 相似文献
5.
为改善超高温瞬时灭菌(ultra-high temperature instantaneous sterilization,UHT)乳中VE的热稳定性,以β-乳球蛋白(β-lactoglobulin,β-LG)和VE为材料制备复合物,探究β-LG对VE热稳定性的影响。通过浊度、粒径、Zeta电位、扫描电子显微镜、十二烷基硫酸钠-聚丙烯酰胺凝胶电泳、红外光谱和荧光光谱研究β-LG与VE的结合情况;利用生物膜干涉技术进一步分析β-LG与VE之间的结合程度;通过高效液相色谱法测定普通强化乳(添加VE)和复合物强化乳(添加β-LG/VE复合物)中UHT前后的VE含量并计算VE热损失率,以确定β-LG对VE热稳定性的影响。结果表明,β-LG可以通过氢键和疏水相互作用与VE结合形成复合物,β-LG与VE结合后,可以减少VE在水溶液中的聚集,使VE的溶解性增加;生物膜干涉技术也证明β-LG与VE之间存在结合,亲和力常数为7.493×10-2?mol/L;复合物强化乳中VE损失率为(4.01±0.18)%,显著低于普通强化乳((10.90±0.17)%)(P<0.05)。以上说明,β-LG可以显著提高VE的热稳定性,为开发维生素强化乳制品提供理论基础。 相似文献
6.
7.
Zhongwei Tan Xingguo Xu Yu Wan Chengjun Kang Zhaoqiang Zhang Zhenxia Zhao Fang Shen Kungang Chai Hongbing Ji 《中国化学工程学报》2022,49(9):150-160
Adsorptive recovery of valuable components from industrial wastewater is highly desirable for avoiding resource wastage but remains a challenge. Herein, we develop an efficient continuous adsorption process for recovering aromatic compounds in wastewater from styrene monomer and propylene oxide co-production (SMPO) plant. Based on our insight into the potential of bio-based porous materials for adsorption application, starch-graft-polystyrene (SPS) and aryl-modified β-cyclodextrin (ACD) were prepared, and novel hypercrosslinked porous polymers combined SPS with ACD (HSPS-ACDs) were synthesized through external crosslinking approach. In a binary-component system, the best-performing one HSPS-ACD(H) with high ACD content and large specific surface area possessed superior capacities for the representative aromatic compounds, acetophenone (AP, 2.81 mmol·g-1) and 1-phenylethanol (1-PE, 1.35 mmol·g-1) compared with the previously reported materials. Further, the adsorption properties of aromatic compounds on HSPS-ACD(H) were investigated in batch mode. For practical application, continuous adsorption experiments were conducted in a HSPS-ACD(H)-packed fixed bed, where the target aromatic components in wastewater were effectively retained and further released by elution. Besides showing the reversible adsorption and efficient enrichment effect, the HSPS-ACD(H)-packed fixed bed also maintained great stability in multiple cycles. Moreover, quantum chemical calculations were performed to elucidate the potential mechanism of adsorption of AP and 1-PE onto HSPS-ACD(H). 相似文献
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9.
抗生素滥用已经成为全世界面临的公共卫生问题,去除环境中残留的抗生素刻不容缓。采用聚氧乙烯月桂醚(Brij30)对β-FeOOH进行表面改性,辅助水热法制备Brij30/β-FeOOH/GO复合材料。通过X-射线粉末衍射仪(XRD)、透射电子显微镜(TEM)、X-射线光电子能谱仪(XPS)、红外光谱仪(FT-IR)和Zeta电位对其组成及微观结构表征。考察了吸附剂投加量、溶液的pH值和共存离子对盐酸四环素(TCH)吸附性能的影响,研究了吸附机理。结果表明,在优化反应条件(Brij30/β-FeOOH/GO投加量0.01 g、溶液pH=5、吸附10 h、TCH初始浓度40 mg/L)下,吸附量达65.97 mg/g,吸附行为符合伪二级动力学方程和Freundlich吸附等温线模型,属于化学吸附并存的多分子层吸附。存在的吸附机理为π-π键堆积、氢键结合、螯合作用和电荷转移。 相似文献
10.
Shanshan Zhuang Wenxiong Zheng Yunong Na Naiyi Chen Fan Gong Bingxuan Huang Stephen Brennan Charles Congyi Liu Jian Cheng Lukai Ma Huifan Liu 《International Journal of Food Science & Technology》2022,57(2):1093-1103
The β-Carotene (BC), an important precursor of vitamin A (VA), possesses antioxidant activity but is fat-soluble and has low bioavailability. In previous in-vitro assays evaluating antioxidant and 2,2′-azobis(2-amidinopropane) dihydrochloride (AAPH) free radical scavenging, both BC and VA showed a strong ability to scavenge radicals and protected cells from oxidative stress. Here, we used artificially simulated gastrointestinal digestion and Caco-2 cell absorption models to evaluate the bioavailability of the BC during gastrointestinal digestion and absorption using high-performance liquid chromatography (HPLC) analysis. We observed high absorptive and transfer rates of BC and detected retinol metabolites (Vitamin A). Therefore, BC can be detected in the acidic gastrointestinal environment using HPLC. Optimised method provided better separation of BC and VA in the column, improving the accuracy of the test results. 相似文献