全文获取类型
收费全文 | 1462篇 |
免费 | 78篇 |
国内免费 | 38篇 |
专业分类
电工技术 | 142篇 |
综合类 | 74篇 |
化学工业 | 865篇 |
金属工艺 | 32篇 |
机械仪表 | 14篇 |
建筑科学 | 17篇 |
矿业工程 | 9篇 |
能源动力 | 35篇 |
轻工业 | 151篇 |
水利工程 | 2篇 |
石油天然气 | 69篇 |
武器工业 | 5篇 |
无线电 | 13篇 |
一般工业技术 | 94篇 |
冶金工业 | 21篇 |
原子能技术 | 18篇 |
自动化技术 | 17篇 |
出版年
2024年 | 7篇 |
2023年 | 12篇 |
2022年 | 33篇 |
2021年 | 43篇 |
2020年 | 37篇 |
2019年 | 33篇 |
2018年 | 30篇 |
2017年 | 47篇 |
2016年 | 56篇 |
2015年 | 53篇 |
2014年 | 83篇 |
2013年 | 89篇 |
2012年 | 112篇 |
2011年 | 104篇 |
2010年 | 83篇 |
2009年 | 78篇 |
2008年 | 46篇 |
2007年 | 93篇 |
2006年 | 74篇 |
2005年 | 83篇 |
2004年 | 58篇 |
2003年 | 56篇 |
2002年 | 32篇 |
2001年 | 34篇 |
2000年 | 42篇 |
1999年 | 28篇 |
1998年 | 22篇 |
1997年 | 18篇 |
1996年 | 17篇 |
1995年 | 11篇 |
1994年 | 15篇 |
1993年 | 12篇 |
1992年 | 11篇 |
1991年 | 5篇 |
1990年 | 8篇 |
1989年 | 3篇 |
1988年 | 1篇 |
1987年 | 1篇 |
1985年 | 2篇 |
1984年 | 1篇 |
1983年 | 2篇 |
1982年 | 1篇 |
1980年 | 1篇 |
1979年 | 1篇 |
排序方式: 共有1578条查询结果,搜索用时 15 毫秒
1.
2.
3.
聚苯硫醚酰胺的合成与表征 总被引:7,自引:1,他引:6
用4-氯苯甲酰4′-氯苯胺和硫化钠为原料在常压下合成了聚苯硫醚酰胺,并对其进行了表征。结果表明所合成的产物为结晶性聚合物,并且有较高的热稳定性。 相似文献
4.
Amir Mohammadzadeh Pter P. Lakatos Mihly Balogh Ferenc Zdor Dvid rpd Kardi Zoltn S. Zdori Kornl Kirly Anna Rita Galambos Szilvia Barsi Pl Riba Sndor Benyhe Lszl Kles Tams Tbi va Szk Laszlo G. Harsing Jr. Mahmoud Al-Khrasani 《International journal of molecular sciences》2021,22(5)
The limited effect of current medications on neuropathic pain (NP) has initiated large efforts to develop effective treatments. Animal studies showed that glycine transporter (GlyT) inhibitors are promising analgesics in NP, though concerns regarding adverse effects were raised. We aimed to study NFPS and Org-25543, GlyT-1 and GlyT-2 inhibitors, respectively and their combination in rat mononeuropathic pain evoked by partial sciatic nerve ligation. Cerebrospinal fluid (CSF) glycine content was also determined by capillary electrophoresis. Subcutaneous (s.c.) 4 mg/kg NFPS or Org-25543 showed analgesia following acute administration (30–60 min). Small doses of each compound failed to produce antiallodynia up to 180 min after the acute administration. However, NFPS (1 mg/kg) produced antiallodynia after four days of treatment. Co-treatment with subanalgesic doses of NFPS (1 mg/kg) and Org-25543 (2 mg/kg) produced analgesia at 60 min and thereafter meanwhile increased significantly the CSF glycine content. This combination alleviated NP without affecting motor function. Test compounds failed to activate G-proteins in spinal cord. To the best of our knowledge for the first time we demonstrated augmented analgesia by combining GlyT-1 and 2 inhibitors. Increased CSF glycine content supports involvement of glycinergic system. Combining selective GlyT inhibitors or developing non-selective GlyT inhibitors might have therapeutic value in NP. 相似文献
5.
Rasheed A. Bailey Derek L. Beahm I. Martha Skerrett 《International journal of molecular sciences》2021,22(5)
Glycine is an amino acid with unique properties because its side chain is composed of a single hydrogen atom. It confers conformational flexibility to proteins and conserved glycines are often indicative of protein domains involving tight turns or bends. All six beta-type connexins expressed in human epidermis (Cx26, Cx30, Cx30.3, Cx31, Cx31.1 and Cx32) contain a glycine at position 12 (G12). G12 is located about halfway through the cytoplasmic amino terminus and substitutions alter connexin function in a variety of ways, in some cases altering protein interactions and leading to cell death. There is also evidence that alteration of G12 changes the structure of the amino terminus in connexin- and amino acid- specific ways. This review integrates structural, functional and physiological information about the role of G12 in connexins, focusing on beta-connexins expressed in human epidermis. The importance of G12 substitutions in these beta-connexins is revealed in two hereditary skin disorders, keratitis ichthyosis and erythrokeratodermia variabilis, both of which result from missense mutations affecting G12. 相似文献
6.
Johann M. Rohwer Chantelle Schutte Rencia van der Sluis 《International journal of molecular sciences》2021,22(6)
The glycine conjugation pathway in humans is involved in the metabolism of natural substrates and the detoxification of xenobiotics. The interactions between the various substrates in this pathway and their competition for the pathway enzymes are currently unknown. The pathway consists of a mitochondrial xenobiotic/medium-chain fatty acid: coenzyme A (CoA) ligase (ACSM2B) and glycine N-acyltransferase (GLYAT). The catalytic mechanism and substrate specificity of both of these enzymes have not been thoroughly characterised. In this study, the level of evolutionary conservation of GLYAT missense variants and haplotypes were analysed. From these data, haplotype variants were selected (156Asn > Ser, [17Ser > Thr,156Asn > Ser] and [156Asn > Ser,199Arg > Cys]) in order to characterise the kinetic mechanism of the enzyme over a wide range of substrate concentrations. The 156Asn > Ser haplotype has the highest frequency and the highest relative enzyme activity in all populations studied, and hence was used as the reference in this study. Cooperative substrate binding was observed, and the kinetic data were fitted to a two-substrate Hill equation. The coding region of the GLYAT gene was found to be highly conserved and the rare 156Asn > Ser,199Arg > Cys variant negatively affected the relative enzyme activity. Even though the 156Asn > Ser,199Arg > Cys variant had a higher affinity for benzoyl-CoA (s0.5,benz = 61.2 µM), kcat was reduced to 9.8% of the most abundant haplotype 156Asn > Ser (s0.5,benz = 96.6 µM), while the activity of 17Ser > Thr,156Asn > Ser (s0.5,benz = 118 µM) was 73% of 156Asn > Ser. The in vitro kinetic analyses of the effect of the 156Asn > Ser,199Arg > Cys variant on human GLYAT enzyme activity indicated that individuals with this haplotype might have a decreased ability to metabolise benzoate when compared to individuals with the 156Asn > Ser variant. Furthermore, the accumulation of acyl-CoA intermediates can inhibit ACSM2B leading to a reduction in mitochondrial energy production. 相似文献
7.
We investigate the thermodynamics, kinetics, and capacity of the hydrogen storage reaction: Li2Mg(NH)2 + 2H2 Mg(NH2)2 + 2LiH. Starting with LiNH2 and MgH2, two distinct procedures have been previously proposed for activating samples to induce the reversible storage reaction. We clarify here the impact of these two activation procedures on the resulting capacity for the Li–Mg–N–H reaction. Additionally, we measure the temperature-dependent kinetic absorption data for this hydrogen storage system. Finally, our experiments confirm the previously reported formation enthalpy (ΔH), hydrogen capacity, and pressure–composition–isotherm (PCI) data, and suggest that this system represents a kinetically (but not thermodynamically) limited system for vehicular on-board storage applications. 相似文献
8.
D-HPG废水的预处理 总被引:1,自引:0,他引:1
D-对羟基苯甘氨酸制药废水 COD高 ,成分复杂。采用 Fe粉及 Fenton试剂预处理 ,COD总去除率高达98%以上。小试确定了 Fe粉加入量为 14 0 g/ L、曝气时间为 7h、Fenton法预处理 D- HPG废水的最佳反应条件 :H2 O2 质量浓度为 2 1.5 g/ L,Fe SO4 质量浓度为 3.8g/ L,氧化时间为 4 h,p H为 5 相似文献
9.
10.
A novel technique for the preparation of secondary fatty amides 总被引:1,自引:0,他引:1
Alexander Bilyk Raymond G. Bistline Jr. George J. Piazza Stephen H. Feairheller Michael J. Haas 《Journal of the American Oil Chemists' Society》1992,69(5):488-491
A technique for the synthesis of monosubstituted fatty amides at low temperature and ambient pressure was developed. This
method involved the condensation of an amine with a triacylglycerol. The primary amine (ethyl,n-butyl,n-hexyl andn-octyl were tested) acted as reagent and solvent for the fatty substrates. No additional organic solvent or catalyst was added.
Tallow, vegetable oils and fish oil all served well as substrates, as did pure tripalmitin. The rate of amidation was dependent
upon temperature and the ratio of fat to amine. In a series of experiments conducted with tallow andn-butylamine at a fat:amine molar ratio of 1:16, amidation could be carried out at 20°C, producingn-butyltallowamide in 83% yield in 24 hr. When the fat:amine molar ratio was reduced to 1:8, and the temperature raised to
45°C, the amide yield was 87.6% in 24 hr. When the reaction was carried out at the boiling point ofn-butylamine (78°C) and at a fat:amine ratio of 1:8, the amide yield was 93.2% in 4 hr. The reaction progressed more rapidly
with higher molecular weight amines. The identity and purity of the amides was assessed by thin-layer chromatography and confirmed
by elemental analyses and infrared and C13 nuclear magnetic resonance spectroscopy. 相似文献