全文获取类型
收费全文 | 260篇 |
免费 | 12篇 |
国内免费 | 2篇 |
专业分类
电工技术 | 2篇 |
综合类 | 14篇 |
化学工业 | 197篇 |
金属工艺 | 3篇 |
机械仪表 | 1篇 |
建筑科学 | 8篇 |
矿业工程 | 1篇 |
轻工业 | 13篇 |
石油天然气 | 18篇 |
无线电 | 1篇 |
一般工业技术 | 15篇 |
冶金工业 | 1篇 |
出版年
2023年 | 3篇 |
2022年 | 4篇 |
2021年 | 12篇 |
2020年 | 7篇 |
2019年 | 5篇 |
2018年 | 3篇 |
2017年 | 2篇 |
2016年 | 9篇 |
2015年 | 1篇 |
2014年 | 2篇 |
2013年 | 20篇 |
2012年 | 6篇 |
2011年 | 14篇 |
2010年 | 13篇 |
2009年 | 13篇 |
2008年 | 11篇 |
2007年 | 20篇 |
2006年 | 17篇 |
2005年 | 17篇 |
2004年 | 12篇 |
2003年 | 9篇 |
2002年 | 8篇 |
2001年 | 12篇 |
2000年 | 5篇 |
1999年 | 10篇 |
1998年 | 6篇 |
1997年 | 2篇 |
1996年 | 5篇 |
1995年 | 3篇 |
1994年 | 3篇 |
1993年 | 3篇 |
1992年 | 2篇 |
1991年 | 3篇 |
1990年 | 1篇 |
1989年 | 2篇 |
1987年 | 3篇 |
1986年 | 2篇 |
1985年 | 2篇 |
1984年 | 1篇 |
1982年 | 1篇 |
排序方式: 共有274条查询结果,搜索用时 31 毫秒
1.
Zifei Yan Yubin Wang Chencan Du Jian Deng Guangsheng Luo 《American Institute of Chemical Engineers》2022,68(11):e17791
Ring-opening of epoxides with carboxylic acids has been widely used to prepare many high value intermediates in the polymer and pharmaceutical industries. Most of conventional processes proceeded in batch stirred reactors. As such they always suffer from low productivity and selectivity. Here we developed an advanced technology to perform the ring-opening reaction of epichlorohydrin with neodecanoic acid (NDA) for continuous production of 3-chloro-2-hydroxypropyl neodecanoate in a more efficient and safer way. A microreaction system where a microreactor connected to a stirred reactor was established. When the conversion of NDA rapidly reaching around 90% in a microreactor at 110°C, the reaction solution was transferred to a stirred reactor at 90°C. This two-stage operating mode can reduce the reaction time and improve the selectivity through free switching of temperature in the consecutive two reactors, thus substantially reducing the consumption of energy and materials. 相似文献
2.
Christian Grin-Ferr Júlia Companys-Alemany Júlia Jarn-Ferrer Sandra Codony Celia Gonzlez-Castillo Daniel Ortuo-Sahagún Lluïsa Vilageliu Daniel Grinberg Santiago Vzquez Merc Palls 《International journal of molecular sciences》2021,22(7)
Niemann–Pick type C (NPC) disease is a rare autosomal recessive inherited childhood neurodegenerative disease characterized by the accumulation of cholesterol and glycosphingolipids, involving the autophagy-lysosome system. Inhibition of soluble epoxide hydrolase (sEH), an enzyme that metabolizes epoxy fatty acids (EpFAs) to 12-diols, exerts beneficial effects in modulating inflammation and autophagy, critical features of the NPC disease. This study aims to evaluate the effects of UB-EV-52, an sEH inhibitor (sEHi), in an NPC mouse model (Npc) by administering it for 4 weeks (5 mg/kg/day). Behavioral and cognitive tests (open-field test (OF)), elevated plus maze (EPM), novel object recognition test (NORT) and object location test (OLT) demonstrated that the treatment produced an improvement in short- and long-term memory as well as in spatial memory. Furthermore, UB-EV-52 treatment increased body weight and lifespan by 25% and reduced gene expression of the inflammatory markers (i.e., Il-1β and Mcp1) and enhanced oxidative stress (OS) markers (iNOS and Hmox1) in the treated Npc mice group. As for autophagic markers, surprisingly, we found significantly reduced levels of LC3B-II/LC3B-I ratio and significantly reduced brain protein levels of lysosomal-associated membrane protein-1 (LAMP-1) in treated Npc mice group compared to untreated ones in hippocampal tissue. Lipid profile analysis showed a significant reduction of lipid storage in the liver and some slight changes in homogenated brain tissue in the treated NPC mice compared to the untreated groups. Therefore, our results suggest that pharmacological inhibition of sEH ameliorates most of the characteristic features of NPC mice, demonstrating that sEH can be considered a potential therapeutic target for this disease. 相似文献
3.
菜豆环氧化物水解酶1和2(PvEH1、PvEH2)能够动力学拆分外消旋邻甲基苯基缩水甘油醚(rac-oMGE),从而保留(R)-oMGE。基于对PvEH1和PvEH2结构的同源模拟和分析,发现二者分子中的盖子环差异较大,故本文选择盖子环作为研究目标。经融合聚合酶链式反应(FPCR),获得了PvEH2的盖子环区域被PvEH1对应区域替换的杂合酶Pv2Pv1。用全细胞酶E. coli/pv2pv1催化rac-oMGE,当(S)-oMGE刚好水解完全时,产物(S)-3-邻甲苯基-1,2-丙二醇((S)-oTPD)的eep由PvEH2的58.3%提高至75.5%。为进一步提高酶的性质,在Pv2Pv1中选取11个氨基酸位点进行丙氨酸(A)突变,获得最优突变子E. coli/pv2pv1K176A,活性为E. coli/pv2pv1(4.2U/g)的2.1倍,且当S构型的底物刚好完全水解时,(S)-oTPD的eep进一步提高为80.3%。分子对接分析发现,盖子环替换和K176位点突变为A,均使(R)-oMGE环氧环中的Cα更易受到酶中D101位点的攻击。利用E. coli/pv2pv1K176A催化150mmol/L rac-oMGE水解制备(R)-oMGE(ees>99%)和(S)-oTPD(eep=80.4%),二者的产率YS和YP分别为32.7%和60.1%,时空产率STYS和STYP为1.6g/(L·h)和3.3g/(L·h)。本实验为改善EH的催化性质提供了一种有效策略。 相似文献
4.
Sadia Salsabil Bristy Mohammad Mostafizar Rahman Mohammad Mahbubor Rahman Mohammad Ashraful Alam Mohammad Rabiul Karim Hasan Ahmad 《International Journal of Applied Ceramic Technology》2019,16(3):1239-1252
In this investigation, magnetic γ-Al2O3 nanocomposite polymer particles with epoxide functionality were prepared following a multistep process. The prepared nanocomposite polymer particle was named as γ-Al2O3/Fe3O4/SiO2/poly(glycidyl methacrylate (PGMA). The surface property was evaluated by carrying out the adsorption study of Remazol Navy RGB (RN), a model reactive azo dye, on both γ-Al2O3/Fe3O4/SiO2 and γ-Al2O3/Fe3O4/SiO2/PGMA nanocomposite particles, that is, before and after epoxide functionalization. A contact time, temperature, adsorbent dose, and dye concentration dependent change in adsorption behavior was observed on both nanocomposite particles. The adsorption amount reached equilibrium (qe) value within 5 minutes at the respective point of zero charge (PZC). The adsorption density of RN per unit specific surface area on epoxide functional γ-Al2O3/Fe3O4/SiO2/PGMA nanocomposite polymer particles (1.30 mg/m2) was higher relative to that on γ-Al2O3/Fe3O4/SiO2 nanocomposite particles (0.87 mg/m2). The optimum adsorbent dose for obtaining the maximum adsorption density was 0.01 g. Comparatively, Langmuir isotherm model was better to describe the adsorption process and the adsorption process was favorable at low temperature (283 K). Batch kinetic adsorption experiment suggested that a pseudo-second-order rate kinetic model is more appropriate. Nanocomposite polymer particles were used as adsorbent up to third cycle with almost 99% adsorption efficiency. 相似文献
5.
焦油聚氨酯有毒、怕水、抗老化能力差 ,采用无莫卡固化剂 ,可以降低毒性 ,能在潮湿面施工。彩色及沥青焦油聚氨酯可以提高抗老化性能。膨胀焦油聚氨酯可代替膨胀橡皮 ,造价低 ,适用已建成的工程伸缩缝止水处理。水溶性环氧树脂适于有水面施工 ,克服了环氧树脂的缺陷 ,应用范围更加广泛。环氧聚氨酯具有刚中有柔的性能 ,适于特殊工程的处理 相似文献
6.
Deepa Jonnalagadda Debin Wan Jerold Chun Bruce D. Hammock Yasuyuki Kihara 《International journal of molecular sciences》2021,22(9)
Polyunsaturated fatty acids (PUFAs) are essential FAs for human health. Cytochrome P450 oxygenates PUFAs to produce anti-inflammatory and pain-resolving epoxy fatty acids (EpFAs) and other oxylipins whose epoxide ring is opened by the soluble epoxide hydrolase (sEH/Ephx2), resulting in the formation of toxic and pro-inflammatory vicinal diols (dihydroxy-FAs). Pharmacological inhibition of sEH is a promising strategy for the treatment of pain, inflammation, cardiovascular diseases, and other conditions. We tested the efficacy of a potent, selective sEH inhibitor, 1-trifluoromethoxyphenyl-3-(1-propionylpiperidin-4-yl) urea (TPPU), in an animal model of multiple sclerosis (MS), experimental autoimmune encephalomyelitis (EAE). Prophylactic TPPU treatment significantly ameliorated EAE without affecting circulating white blood cell counts. TPPU accumulated in the spinal cords (SCs), which was correlated with plasma TPPU concentration. Targeted lipidomics in EAE SCs and plasma identified that TPPU blocked production of dihydroxy-FAs efficiently and increased some EpFA species including 12(13)-epoxy-octadecenoic acid (12(13)-EpOME) and 17(18)-epoxy-eicosatrienoic acid (17(18)-EpETE). TPPU did not alter levels of cyclooxygenase (COX-1/2) metabolites, while it increased 12-hydroxyeicosatetraenoic acid (12-HETE) and other 12/15-lipoxygenase metabolites. These analytical results are consistent with sEH inhibitors that reduce neuroinflammation and accelerate anti-inflammatory responses, providing the possibility that sEH inhibitors could be used as a disease modifying therapy, as well as for MS-associated pain relief. 相似文献
7.
Erkan Ertürk Mustaf Ali Tezeren Tahir Tilki Tuba Erdogan Ahmet C Gren 《Polymer International》2012,61(5):795-799
The readily available mixed‐valent iron trifluoroacetate complex [Fe2IIIFeII(µ3‐O)(O2CCF3)6(H2O)3] is an effective catalyst for the polymerization of epoxides. A very small amount of the catalyst (1.0–0.01 mol%) could initiate the polymerization of cyclohexene oxide, cyclopentene oxide and epichlorohydrin. Based on quantitative end‐group analysis by 19F NMR spectroscopy, a Lewis acid (LA⊕) catalyzed anionic reaction mechanism is proposed. Copyright © 2012 Society of Chemical Industry 相似文献
8.
9.
Alternating copolymers of carbon dioxide with glycidyl ethers for novel ion-conductive polymer electrolytes 总被引:1,自引:0,他引:1
To overcome the low ionic conduction of existing poly(ethylene oxide)-based polymer electrolytes, we consider polycarbonates obtained from the copolymerization of CO2 and epoxy monomers. We synthesized four types of polycarbonates possessing phenyl, n-butyl, t-butyl and methoxyethyl side groups using zinc glutarate, and measured the ionic conductivity of their electrolytes, including 10 mol% of LiTFSI. The electrolyte possessing methoxyethyl side groups had the highest conductivity, of the order of 10−6 S cm−1 at room temperature. The activation energy (Ea) for ionic conduction in the polycarbonate electrolytes was estimated from the VTF equation, and the Ea of the electrolyte possessing n-butyl side groups was almost the same with the polyether-based electrolytes. An interesting feature of our study is that the polycarbonate is a unique candidate for ion-conductive polymers because of its flexible and hydrophobic properties. 相似文献
10.
Mamdouh Al‐Harthi 《加拿大化工杂志》2011,89(2):384-391
A stochastic model was developed to simulate the polymerisation kinetics and the detailed microstructure of the resulting polymers made by the living radical polymerisation of styrene initiated by epoxide radical ring opening. The model was used to predict monomer conversion, average molecular weight, polydispersity index, and molecular weight distribution as a function of polymerisation time. Simulations were used to explore the effects of rate constant values on chain microstructures and polymer properties and validated with experimental data published in the literature. It was found that some parameters, such as the exchange rate constant, have no significant effect on the polymerisation kinetics, whereas major effects were observed when other rate constants, such as the reduction rate constant, were changed. 相似文献