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目的 了解武汉市一般人群血清中全氟及多氟烷基化合物(PFASs)浓度,探索血清中PFASs浓度水平的影响因素。方法 以在武汉市某医院进行一般体检的人群为研究对象(n=67),通过超高效液相色谱-三重四级杆质谱(UPLC-TQ/MS)联用仪测定外周血清中12种PFASs浓度,采用多元线性回归分析方法分析一般人口学特征和血清中PFASs浓度的关联性。结果 武汉市一般人群血清中12种PFASs的平均浓度水平为11.60 ng/mL。全氟辛烷磺酸及其盐类(PFOS)和全氟辛酸及其盐类(PFOA)的贡献率较大,分别为45.03%和31.86%。男性人群血清中PFOS、PFOA、全氟己基磺酸(PFHxS)、全氟壬酸(PFNA)等主要化合物的浓度高于女性,其β值(95%可信区间)分别为0.708(0.313,1.104)、0.518(0.069,0.967)、0.724(0.388,1.059)和0.684(0.399,0.968)。同时,发现血清中PFOS、PFHxS、PFNA浓度和年龄呈正相关,其β值(95%可信区间)分别为0.062(0.042,0.081)、0.035(0.019,0.052)和0.030(0.016,0.045)。结论 性别和年龄对血清中PFASs浓度有影响,在进行人体PFASs暴露评估中应考虑这些因素。 相似文献
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Dr. Franz-Josef Schmitt Dr. Stefan Frielingsdorf Prof. Dr. Thomas Friedrich Prof. Dr. Nediljko Budisa 《Chembiochem : a European journal of chemical biology》2021,22(5):818-825
Synthetic biology and especially xenobiology, as emerging new fields of science, have reached an intellectual and experimental maturity that makes them suitable for integration into the university curricula of chemical and biological disciplines. Novel scientific fields that include laboratory work are perfect playgrounds for developing highly motivating research-based teaching modules. We believe that research-based learning enriched by digital tools is the best approach for teaching new emerging essentials of academic education. This is especially true when the scientific field as such is still not canonized with text books and best-practice examples. Our experience shows that iGEM/BIOMOD competitions represent an excellent basis for designing research-based courses in xenobiology. Therefore, we present a report on “iGEM–Synthetic Biology” offered at the Technische Universität Berlin as an example. 相似文献
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A general solution technique for non-axisymmetric thermoelectroelastic problems in cylindrical domains with D∞ symmetry is constructed. The displacement and electric field are expressed in terms of the respective potential functions, and the thermoelectroelastic field quantities are expressed in terms of the elastic and piezoelastic potential functions, each of which essentially satisfies a Laplace equation with respect to the spatial coordinates, combined with the two thermoelastic displacement potential functions. As an application of the technique, the theoretical analysis of a solid cylinder subjected to combined mechanical and thermal loading is performed, and the necessity of the thermoelectroelastic analyses is demonstrated. 相似文献
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Henrik Szentes 《Construction Management & Economics》2018,36(3):125-140
In recent years, scholars have shown a growing interest in combining control and flexibility when organizing and managing large construction projects, in contrast with the traditional focus on control. Prior research recognizes that there is a paradoxical tension between control and flexibility, meaning that, while both approaches make sense individually, they appear impossible to combine. Large construction projects are interorganizational, which means that tensions between interorganizational control/flexibility coexist with tensions between intraorganizational direction/empowerment, but the interplay and possible reinforcing cycles involving the two tensions have rarely been investigated in prior research. A multiple case study of four large construction projects with three rounds of interviews show how intraorganizational direction/empowerment can influence interorganizational control/flexibility and vice versa, and demonstrate both vicious and virtuous reinforcing cycles that involve the two types of tensions. Therefore, contributing to the project management and construction management literature, it is argued that employing a systemic approach when studying interorganizational projects is essential. A systemic paradox perspective can reveal interdependencies between tensions at different organizational interfaces, improve the understanding of how individuals in all managerial positions interplay, and explain how reinforcing cycles emerge and develop; this is important to recognize when organizing, staffing and managing large construction projects. 相似文献
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水利工程的特殊性,决定了其在安全管理构建中更加注重全过程管理机制的构建,以及危险源下的精准安全管控。在传统安全管理模式之下,水利工程安全管理盲点多、效率低,不利于全过程安全管理的高效实施。文章立足水利工程的危险辨识,分析了水利工程危险源全过程安全管理中的问题,并在此基础之上,从强化危险源精准辨识、构建危险源动态管理机制、优化危险源评价工作、加快危险源信息库建设等方面,具体论述了危险源下水利工程全过程安全管理措施。 相似文献
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《International Journal of Project Management》2020,38(2):137-151
This exploratory study provides an influence diagram that shows the network of conditions that influence the use of visuals to effectively engage executives. The diagram was developed from the experiences of project managers and executives elicited through twenty-four semi-structured interviews. Twenty-nine conditions are found to influence the use of visuals to effectively engage executives. These are grouped into four categories: the executive's disposition to the use of visuals; the organisational conditions to create visuals; the project manager's understanding of the executive's information needs; and the executive's and project manager's appreciation of the benefits of using visuals. The study's results highlight that while the interviewed executives had a predisposition to the use of visuals as they are generally time-poor, capability to create visuals to support executive engagement was not widespread. Practical contributions include disclosing the criticality of organisational support for creating visuals and the vulnerability of executives in making project decisions. 相似文献