全文获取类型
收费全文 | 259篇 |
免费 | 27篇 |
国内免费 | 8篇 |
专业分类
电工技术 | 1篇 |
综合类 | 14篇 |
化学工业 | 106篇 |
金属工艺 | 4篇 |
建筑科学 | 1篇 |
轻工业 | 113篇 |
无线电 | 3篇 |
一般工业技术 | 49篇 |
原子能技术 | 1篇 |
自动化技术 | 2篇 |
出版年
2024年 | 2篇 |
2023年 | 4篇 |
2022年 | 6篇 |
2021年 | 24篇 |
2020年 | 8篇 |
2019年 | 9篇 |
2018年 | 9篇 |
2017年 | 13篇 |
2016年 | 11篇 |
2015年 | 12篇 |
2014年 | 8篇 |
2013年 | 23篇 |
2012年 | 22篇 |
2011年 | 17篇 |
2010年 | 22篇 |
2009年 | 6篇 |
2008年 | 8篇 |
2007年 | 11篇 |
2006年 | 13篇 |
2005年 | 10篇 |
2004年 | 5篇 |
2003年 | 9篇 |
2002年 | 16篇 |
2001年 | 4篇 |
2000年 | 3篇 |
1999年 | 2篇 |
1998年 | 2篇 |
1997年 | 6篇 |
1996年 | 2篇 |
1995年 | 1篇 |
1993年 | 4篇 |
1991年 | 1篇 |
1990年 | 1篇 |
排序方式: 共有294条查询结果,搜索用时 15 毫秒
1.
This study aimed to prepare cisplatin-loaded PEGylated liposomal nanoparticles targeted with folic acid and evaluate their efficacy on liver cancer cell line PLC/PRF/5 (Alexander hepatoma cell line). Nanoparticles were prepared by reverse phase evaporation technique and characterized by dynamic light scattering, scanning electron microscopy, transmission electron microscopy, inductively coupled plasma optical emission spectrometry, Fourier transform infrared spectroscopy, and 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide techniques. Nanoscale particles with appropriate drug encapsulation efficiency (13%) were prepared. Cytotoxicity results indicated that the superior potency of targeted cisplatin-loaded nanoparticles compared to the nontargeted counterpart with 23% more cytotoxicity. Findings of this study confirmed the potency of targeted PEGylated liposomal nanoparticles. 相似文献
2.
Shuangjiang Feng Shuxue Wang Yuanfei Lv Lei He Qiurong Li Tao Zhang 《Polymer International》2019,68(3):494-502
Hydrogels have been widely used as mild biomaterials due to their bio‐affinity, high drug loading capability and controllable release profiles. However, hydrogel‐based carriers are greatly limited for the delivery of hydrophobic payloads due to the lack of hydrophobic binding sites. Herein, nano‐liposome micelles were embedded in semi‐interpenetrating poly[(N‐isopropylacrylamide)‐co‐chitosan] (PNIPAAm‐co‐CS) and poly[(N‐isopropylacrylamide)‐co‐(sodium alginate)] (PNIPAAm‐co‐SA) hydrogels which were responsive to both temperature and pH, thereby establishing tunable nanocomposite hydrogel delivery systems. Nano‐micelles formed via the self‐assembly of phospholipid could serve as the link between hydrophobic drug and hydrophilic hydrogel due to their special amphiphilic structure. The results of transmission and scanning electron microscopies and infrared spectroscopy showed that the porous hydrogels were successfully fabricated and the liposomes encapsulated with baicalein could be well contained in the network. In addition, the experimental results of response release in vitro revealed that the smart hydrogels showed different degree of sensitiveness under different pH and temperature stimuli. The results of the study demonstrate that combining PNIPAAm‐co‐SA and PNIPAAm‐co‐CS hydrogels with liposomes encapsulated with hydrophobic drugs is a feasible method for hydrophobic drug delivery and have potential application prospects in the medical field. © 2018 Society of Chemical Industry 相似文献
3.
Zhuo Zhang Sen Peng Xiaoqi Sun Yu Jie Hongfei Zhao Baoqing Zhu 《Drying Technology》2020,38(14):1843-1856
AbstractThis study constructed a β-galactosidase (β-gal) liposome model instead of bacterial cells to optimize spray-drying protectants and parameters. The screened protectant combination consisted of 35?g/L monosodium glutamate, 50?g/L sucrose, and 35?g/L maltodextrin. The optimal parameters for spray drying were 130?°C inlet air temperature, 7.5?mL/min feed flow rate, and 150?mL optimal protectant combination. The viability of the five lactic acid bacteria strains spray-dried with the optimized protectant and parameters was over 50%. Lactobacillus helveticus strain LH-9’s mechanism of resistance to spray-dry treatment was investigated in the presence of the optimal protectant combination. 相似文献
4.
Liposomes have been used widely as carriers for active ingredients in cosmetics because of their ability to encapsulate both hydrophilic and hydrophobic compounds. In this work, fatty acid liposomes were prepared and introduced into olive oil-in-water emulsions stabilized by C14–C18 sucrose ester mixtures at pH 8.5. Light microscopy images of the emulsions showed evidence of the coexistence of oleic acid liposomes with the emulsions. As the alkyl chain length of the sucrose ester increased, the average droplet size decreased, while the zeta potential became more negative. Further decrease in droplet size was observed when borate buffer was added to the aqueous phase. The free fatty acids in the sucrose esters and olive oil are neutralized in borate buffer; consequently, fatty acid salts were produced and served as co-surfactants. The synergistic stabilization of emulsions by the mixture of sucrose esters and fatty acid salt resulted in higher stability, smaller droplet size, and lower polydispersity. The drastic increase in negative zeta potential was possibly due to the presence of free fatty acid salts in the emulsion systems. The flow curves at steady rate displayed five distinctive regions. The polydispersity of droplets enhanced the shear thickening effect at low shear rates and shear-banding effect at middle shear rates. Formation of fatty acid salts as co-surfactants caused the viscosities of the emulsions to increase by an order of magnitude. The presence of oleic acid liposome significantly reduced the viscosities of the emulsion by half an order of magnitude; this decreased viscosity helped enhance better spreadability. 相似文献
5.
Improved physical stability of docosahexaenoic acid and eicosapentaenoic acid encapsulated using nanoliposome containing α‐tocopherol 下载免费PDF全文
Mohammad Ali Sahari Hamid Reza Moghimi Zahra Hadian Mohsen Barzegar Abdoreza Mohammadi 《International Journal of Food Science & Technology》2016,51(5):1075-1086
This study aimed to develop a nanoliposomal formulation containing α‐tocopherol loaded with eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) and to characterise the formulation by its physical stability. For this purpose, different nanoliposomal formulations with dipalmitoyl phosphocholine were prepared using a modified thin‐film hydration method and evaluated by particle size, polydispersity index (PDI), transmission electron microscopy, differential scanning calorimetry and determining the encapsulation efficiencies of DHA and EPA. A physical stability study was conducted by investigating the change in the vesicle encapsulation efficiency, particle size, PDI and shape when stored at 4, 30 and 40 °C for 3 months. High encapsulation efficiency of DHA and EPA (89.1% ± 0.6% and 81.9% ± 1.4%) and appropriate particle size (82 ± 0.8 nm) were obtained for liposomes composed of α‐tocopherol. The optimum formulation was stable for 90 days when kept at 4 °C. This study demonstrated that α‐tocopherol had a protective effect on the physical stability of the nanoliposomes containing DHA and EPA. 相似文献
6.
7.
8.
采用薄膜分散法制备格列齐特脂质体,以粒径和包封率为考核指标,通过单因素实验和正交实验优化制备条件,测定最优条件制备格列齐特脂质体的平均粒径和包封率。确定最优制备条件为:药脂比1∶10(g∶g)、超声时间10min、成膜温度60℃、缓冲液pH值6。所制备脂质体的平均粒径为(108.3±12.4)nm、包封率为(72.19±3.6)%、平均Zeta电位为(-40.8±2.3)mV,且在4℃下保存稳定性好。电镜照片显示,所制备脂质体圆整度好、粒径均一、无粘连。表明采用薄膜分散法制备格列齐特脂质体工艺稳定,质量可控。 相似文献
9.
10.