Engineering Bioactive M2 Macrophage-Polarized Anti-Inflammatory,Antioxidant, and Antibacterial Scaffolds for Rapid Angiogenesis and Diabetic Wound Repair

Diabetic wound healing still faces great challenges due to the excessive inflammation, easy infection, and impaired angiogenesis in wound beds. The immunoregulation of macrophages polarization toward M2 phenotype that facilitates the transition from inflammation to proliferation phase has been proved to be an effective way to improve diabetic wound healing. Herein, an M2 phenotype-enabled anti-inflammatory, antioxidant, and antibacterial conductive hydrogel scaffolds (GDFE) for producing rapid angiogenesis and diabetic wound repair are reported. The GDFE scaffolds are fabricated facilely through the dynamic crosslinking between polypeptide and polydopamine and graphene oxide. The GDFE scaffolds possess thermosensitivity, self-healing behavior, injectability, broad-spectrum antibacterial activity, antioxidant and anti-inflammatory ability, and electronic conductivity. GDFE effectively activates the polarization of macrophages toward M2 phenotype and significantly promotes the proliferation of dermal fibroblasts, the migration, and in vitro angiogenesis of endothelial cells through paracrine mechanisms. The in vivo results from a full-thickness diabetic wound model demonstrate that GDFE can rapidly promote the diabetic wound repair and skin regeneration, through fast anti-inflammation and angiogenesis and M2 macrophage polarization. This study provides highly efficient strategy for treating diabetic wound repair through designing the M2 polarization-enabled anti-inflammatory, antioxidant, and antibacterial bioactive materials.     

Structural Cues for Understanding eEF1A2 Moonlighting

Spontaneous mutations in the EEF1A2 gene cause epilepsy and severe neurological disabilities in children. The crystal structure of eEF1A2 protein purified from rabbit skeletal muscle reveals a post-translationally modified dimer that provides information about the sites of interaction with numerous binding partners, including itself, and maps these mutations onto the dimer and tetramer interfaces. The spatial locations of the side chain carboxylates of Glu301 and Glu374, to which phosphatidylethanolamine is uniquely attached via an amide bond, define the anchoring points of eEF1A2 to cellular membranes and interorganellar membrane contact sites. Additional bioinformatic and molecular modeling results provide novel structural insight into the demonstrated binding of eEF1A2 to SH3 domains, the common MAPK docking groove, filamentous actin, and phosphatidylinositol-4 kinase IIIβ. In this new light, the role of eEF1A2 as an ancient, multifaceted, and articulated G protein at the crossroads of autophagy, oncogenesis and viral replication appears very distant from the “canonical” one of delivering aminoacyl-tRNAs to the ribosome that has dominated the scene and much of the thinking for many decades.     

Alternating Multilayer Structural Epoxy Composite Coating for Corrosion Protection of Steel

Epoxy composite coatings filled with fillers have been used extensively as anticorrosion materials. In this study, an alternating multilayer structure is designed to obtain multifunctional epoxy resin composite coating based on stepwise coating method via adding graphene and α‐alumina. Their mechanical properties, thermal conductivity, dielectric and anticorrosion properties are characterized. The toughness and the thermal conductivity clearly increase, while the dielectric properties decrease approximately to zero when the filler mass fraction increases from 0.00% to 0.15%. The whole corrosion process is controlled by electrochemical reaction, and the fillers effectively block the corrosive medium, thus improving the anticorrosion performance of the composite coating.     

棉织物的硅溶胶疏水整理

为实现超疏水织物的绿色加工,采用正硅酸乙酯(TEOS)为前驱体,乙醇和水为溶剂制备硅溶胶预缩体对棉织物进行疏水整理,研究各工艺因素对棉织物疏水性能的影响,重点分析预缩体的制备、硅烷偶联剂的添加、低温烘干工艺与提高整理织物疏水性的相关性。结果表明:棉织物表面的SiO₂纳米粒子形成的粗糙表面与织物表面结合的疏水脂肪烃链可赋予织物良好的疏水性;在TEOS量为0.1 mol,乙醇量为0.9 mol,水的量为0.8 mol,先二浸二轧硅溶胶,再浸轧十六烷基三甲氧基硅烷醇溶剂优化工艺条件下,整理棉织物的水接触角可达152.1°,棉织物的力学性能得到提高。     

超细纤维合成革的染色与功能整理研究进展

为了解决超细纤维合成革在制备、染色以及功能整理等方面出现的问题,系统阐述了超细纤维合成革的发展历程以及未来超细纤维合成革的发展方向;分析了染色工艺、染色助剂、染色基布的改性对聚酰胺超细纤维合成革染色性能的影响,评述了聚酯超细纤维合成革的染色现状;总结了国内超细纤维合成革经功能整理后的附加性能,包括阻燃、防污、抗静电、抗菌、耐寒、调温等。最后指出了未来超细纤维合成革在制备方式、高性能染色以及功能化整理方面应大力发展的方向,以对企业的产品优化升级、提高产品的市场竞争力提供指导。     

硅氧烷功能化石墨烯改性有机硅皮革手感剂的稳定性与应用

硅氧烷功能化石墨烯具有良好的分散性与稳定性,功能化石墨烯改性有机硅具有良好的耐酸、耐碱能力。本文使用纳米粒度及电位分析仪、Taber耐磨试验机、摩擦褪色试验机等测试了硅氧烷功能化石墨烯改性有机硅的zeta电位、纳米粒度、粒径分布及成革物理机械性能,结果表明:石墨烯改性有机硅在pH值为0.5~11.5时稳定性高;碱性越强,纳米粒度越大,粒径分布越集中,粒径分布系数越小;酸性越强,粒径分布越分散,粒径分布系数越大。将硅氧烷功能化石墨烯与聚氨酯光亮剂或硝化棉光亮剂共混应用于皮革顶层涂饰,能显著提升涂层物理机械性能,且石墨烯改性有机硅对聚氨酯光亮剂的增强效果高于硝化棉光亮剂。     

氟硅烷改性CuS/SiO2复合气凝胶的超双疏防紫外线纺织品

以甲基三甲氧基硅烷(MTMS)为前驱体,在溶胶-凝胶反应过程中,加入纳米CuS,并采用十七氟癸基三乙氧基硅烷(PFDTES)对其改性,成功制备了氟硅烷改性CuS/SiO2复合气凝胶(F-CuS/SiO2),并将其与聚二甲基硅氧烷(PDMS)混合应用到棉织物上,制备了超双疏防紫外多功能棉织物。探讨了F-CuS/SiO2质量分数、PDMS质量分数、焙烘温度、焙烘时间等主要因素对整理棉织物疏水性能的影响。结果表明:当F-CuS/SiO2气凝胶为2%,PDMS为1%,焙烘温度为160℃,焙烘时间为8 min时,整理棉织物的疏水性能最佳,水滴接触角可达159.4°,油滴接触角可达151.8°,紫外线防护系数(UPF)为237.43,整理棉织物具有良好的超双疏防紫外自清洁效果。     

涤纶针织布的有机硅改性聚酯-聚醚共聚物整理

采用酯交换-缩聚反应,在催化剂与稳定剂的作用下,以对苯二甲酸二甲酯、乙二醇、聚乙二醇与自制聚醚硅油为原料合成了有机硅聚酯-聚醚共聚物整理剂。试验探究了聚醚硅油的用量对反应产物性能的影响,通过红外光谱表征了有机硅聚酯-聚醚共聚物的结构,并对其在涤纶针织物上的最佳应用条件进行了研究。结果表明:聚醚硅油用量占酯交换反应物质量分数为6%时,用其处理的针织物亲水性和手感较好;最佳使用工艺条件为浸轧法,质量浓度20 g/L,120℃焙烘60s。     

综采工作面收尾技术研究与应用

陈四楼煤矿于1997年投产，随开采年限的增加矿井开采深度逐渐增加，综采工作面回采条件日益复杂，综采工作面布置受地质构造影响越来越大，致使小储量的综采工作面出现次数和综采工作面搬家次数逐渐增多，综采工作面收尾越发频繁。采取合适的综采工作面收尾方法，对提高综采工作面收尾速度、确保综采工作面收尾安全起到至关重要的作用，对确保综采工作面安全、高效回撤起到至关重要作用，对缓解矿井采掘接替紧张也起到一定作用。介绍了陈四楼煤矿2802综采工作面地质条件、主要生产系统及设备布置，通过对比、分析，总结和说明了综采工作面收尾上网上绳阶段及扩通道阶段采用的两种不同方法的优缺点，为今后综采工作面收尾方法的选取提供了理论和实践依据。     

Progress in the design of zeolite catalysts for biomass conversion into biofuels and bio-based chemicals

This article reviews the recent advances in the development of zeolite catalysts for biomass valorization processes to produce both biofuels and/or bio-based chemicals, which is an emerging and fast expanding field. The work deals with different types of feedstocks, including vegetable oils, lignocellulose and sugars, as well as with a number of relevant intermediates and platform molecules. Transformation of biomass into valuable products is hindered by a number of factors, mainly related to its complex composition, as biomass typically consists of bulky molecules with high oxygen content. Accordingly, biomass processing usually requires the combination of multiple steps and severe conditions, hence concepts like atom efficiency, product selectivity, and catalyst deactivation become of special relevance. A great progress has been achieved in the past years engineering the properties of zeolites for being adapted to the challenges associated to biomass valorization. The possibility of tailoring the main physicochemical properties of zeolites has become now a reality, being the major reason that explains the success achieved by this class of materials in a growing variety of biomass conversion pathways, as those described in this work: catalytic cracking and pyrolysis, hydrotreatments, with special relevance for hydrodeoxygenation processes, as well as in a high number of condensation, isomerization, and dehydration reactions. Thus, the development of hierarchical zeolites, exhibiting enhanced accessibility, and the possibility of introducing and combining in a controlled way different types of active sites (Brønsted and Lewis acid centers, basic sites, and metal phases) are the main basis of the excellent performance of zeolites in numerous biomass conversion routes.