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Yanmiao Fan Mads Lüchow Yuning Zhang Jinjian Lin Lisa Fortuin Soumitra Mohanty Annelie Brauner Michael Malkoch 《Advanced functional materials》2021,31(7):2006453
Biocompatible and degradable dual-delivery gel systems based on hyperbranched dendritic−linear−dendritic copolymers (HBDLDs) is herein conceptualized and accomplished via thiol-ene click chemistry. The elasticity of the hydrogels is tunable by varying the lengths of PEG (2, 6, 10 kDa) or the dry weight percentages (20, 30, 40 wt%), and are found to range from 2–14.7 kPa, comparable to human skin. The co-delivery of antibiotics is achieved, where the hydrophilic drug novobiocin sodium salt (NB) is entrapped within the hydrophilic hydrogel, while the hydrophobic antibiotic ciprofloxacin (CIP) is encapsulated within the dendritic nanogels (DNGs) with hydrophobic cores (DNGs-CIP). The DNGs-CIP with drug loading capacity of 2.83 wt% are then physically entrapped within the hybrid hydrogels through UV curing. The hybrid hydrogels enable the quick release of NB and prolonged released of CIP. In vitro cell infection assays showed that the antibiotic-loaded hybrid hydrogels are able to treat bacterial infections with significant bacterial reduction. Hybrid hydrogel band aids are fabricated and exhibited better antibacterial activity compared with commercial antimicrobial band aids. Remarkably, most hydrogels and hybrid hydrogels show enhanced human dermal cell proliferation and could be degraded into non-toxic constituents, showing great promise as wound dressing materials. 相似文献
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A series of partially photodegradable o‐nitrobenzyl nanogels (NBNG) with different caged functional groups (COOH, OH, SH) are prepared and compared with a nondegradable nanogel as additives in photocurable materials. Photoinduced nanogel network disruption and photoinitiated polymerization of infiltrating and dispersing monomer could be controlled independently. In triethylene glycol dimethacrylate (TEGDMA), o‐NBNGs that release a COOH or OH functional group upon photodegradation of the o‐nitrobenzyl crosslinker, the reduced chemical crosslinking density of the nanogel network allows greater penetration of monomer into the partially degraded nanogel network, which results in an increase in volumetric shrinkage and polymerization stress. In contrast, the formulation of o‐NBNGs with caged SH groups also can be photodegraded but is able to rebuild the chemical crosslinking through thiol‐based chain transfer reactions when photocured as a dispersion in TEGDMA. As such, it behaves like a photo‐inert nanogel. Dynamic thermomechanical analysis and testing by three‐point bending further confirms the photoinduced crosslink density variation influences mechanical properties of the final polymer networks. This work demonstrates the inherent properties of the nanogel network and the type of crosslinking can alter the performance of the photocured resin while a separate photochemical process can be used to regulate photoinduced polymerization. 相似文献
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《Small Methods》2018,2(3)
Polymer nanogels, which are nanosized particles of hydrogels formed by physically or chemically crosslinking polymers, are one of the most promising nanoplatforms for use in biomedical applications, including drug delivery, gene therapy, and bioimaging. Polypeptide nanogels exhibit many advantages for applications in biomedical fields, including stable 3D structures, high drug‐loading efficiency, excellent biocompatibility, stimuli responsiveness, and so forth. More specifically, smart polypeptide nanogels undergo suitable transitions under endogenous (e.g., reduction, reactive oxygen species, pH, and enzymes) or exogenous stimuli (e.g., light, temperature, voltage, and magnetic fields) for on‐demand drug delivery. Here, a comprehensive introduction to the preparation and applications of diverse stimuli‐responsive polypeptide nanogels is given. Moreover, the opportunities and challenges of polypeptide nanogels for the development of biomedicine are briefly predicted. 相似文献
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以甲基丙烯酸羟乙酯(HEMA)和甲基丙烯酸(MAA)为聚合单体,异辛烷为分散介质,Span80和Tween80为复配乳化剂,采用反相微乳液聚合法制得不同单体配比的聚(甲基丙烯酸羟乙酯-co-甲基丙烯酸)(P(HEMA-co-MAA))纳米凝胶。确定了产物的pKa值及实际单体物质的量比,对产物的形貌进行了表征并研究了产物的pH响应性.结果显示,MAA物质的量分数为20%的纳米凝胶的pKa值为5.83,在pH=3和pH=7时其数均粒径分别为48 nm和90 nm;当环境pH接近pKa值时,纳米凝胶分散液的浊度明显降低,溶胀率明显上升,表观黏度急剧增加,说明纳米凝胶具有良好的pH响应性。 相似文献
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Aracely Serrano-Medina Irasema Oroz-Parra Victor E. Gomez-Resendiz Alexei Licea-Navarro 《国际聚合物材料杂志》2018,67(1):20-26
Temperature- and pH-sensitive core–shell nanogels were prepared by one-pot soapless emulsion polymerization of N-isopropylacrylamide and 2-methacryloyloxy benzoic acid with the aid of a crosslinker (core) using poly(ethylene glycol) methyl ether methacrylate as stabilizer (shell). The size of nanogels depended on the crosslinker used, being considerable smaller (around 100?nm) with the use of the acid-labile crosslinker 9-divinyl-2,4,8,10-tetraoxaspiro[5.5]-undecane (DVA). Doxorubicine (DOX) was loaded in nanogels with good efficiency. The empty nanogels were biocompatible for a lung cancer cell line (NCI-H1437), while the DOX-loaded, DVA-crosslinked nanogels resulted with efficient cytotoxicity for that cell line. 相似文献
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Cationic Nanogels: Reduction‐Sensitive Dextran Nanogels Aimed for Intracellular Delivery of Antigens (Adv. Funct. Mater. 20/2015) 
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Jakes Udabe Amanda Muñoz-Juan Belal Tafech María Soledad Orellano Sarah Hedtrich Anna Laromaine Marcelo Calderón 《Advanced functional materials》2024,34(45):2407044
Mucus is a hydrated, viscoelastic, and adhesive gel that lubricates and protects the body from pathogens; however, its protective function hinders drug/nanomedicine diffusion and treatment efficiency. Therefore, novel drug delivery strategies are required to overcome challenging mucosal barriers. Here, multi-responsive nanogels (NGs) are developed and explored their interaction with mucus. Specific NG features (e.g., surface charge, temperature responsiveness, and redox response) are evaluated in a typical mucus-associated environment (i.e., mucin proteins and high glutathione concentrations). The results demonstrate that biocompatibility and the capacity to deliver a protein through mucosal barriers in different in vitro and in vivo models highlight the importance of specific NG design elements. Disulfide bonds are highlighted as redox-sensitive cross-linkers within the NG structure as critical for drug delivery performance; they function as degradation points that enable NG degradation and subsequent drug release and anchoring points to adhere to mucin, thereby enhancing their residence time at the desired site of action. Additionally, it is confirmed that surface charges impact interactions with mucin; positively charged NGs exhibit improved interactions with mucin compared to negatively charged and neutral NGs. Overall, the findings underline the importance of redox response and surface charge in NG design for reaching efficient mucosal drug delivery. 相似文献
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《国际聚合物材料杂志》2012,61(3):155-167
Extensive research has been carried out for developing nanocarriers to overcome the major barriers preventing success in oral insulin therapy, which includes (a) identification of in vivo barriers, (b) incorporation of prerequisite characteristics into single nanocarrier, and (c) exclusion of the use of additional potentially toxic chemicals as enzyme inhibitors or permeation enhancers. The present review identifies the prerequisite characteristics of single nanocarrier that could avoid major hindrance being faced in oral insulin delivery. An effort is made to discuss the involvement of prerequisite characters to overcome the major hurdles, which prevent the success in oral insulin delivery. 相似文献