全文获取类型
收费全文 | 266篇 |
免费 | 13篇 |
国内免费 | 37篇 |
专业分类
电工技术 | 1篇 |
综合类 | 18篇 |
化学工业 | 120篇 |
金属工艺 | 57篇 |
机械仪表 | 3篇 |
建筑科学 | 1篇 |
轻工业 | 34篇 |
石油天然气 | 62篇 |
一般工业技术 | 16篇 |
冶金工业 | 2篇 |
原子能技术 | 2篇 |
出版年
2024年 | 1篇 |
2023年 | 1篇 |
2022年 | 6篇 |
2021年 | 5篇 |
2020年 | 5篇 |
2019年 | 4篇 |
2018年 | 4篇 |
2017年 | 11篇 |
2016年 | 10篇 |
2015年 | 11篇 |
2014年 | 15篇 |
2013年 | 13篇 |
2012年 | 28篇 |
2011年 | 35篇 |
2010年 | 20篇 |
2009年 | 29篇 |
2008年 | 6篇 |
2007年 | 10篇 |
2006年 | 19篇 |
2005年 | 12篇 |
2004年 | 11篇 |
2003年 | 10篇 |
2002年 | 7篇 |
2001年 | 11篇 |
2000年 | 7篇 |
1999年 | 5篇 |
1998年 | 5篇 |
1997年 | 2篇 |
1996年 | 3篇 |
1995年 | 2篇 |
1994年 | 1篇 |
1993年 | 1篇 |
1992年 | 1篇 |
1990年 | 2篇 |
1987年 | 2篇 |
1979年 | 1篇 |
排序方式: 共有316条查询结果,搜索用时 15 毫秒
1.
Dr. Jessica Ceramella Dr. Annaluisa Mariconda Dr. Camillo Rosano Dr. Domenico Iacopetta Dr. Anna Caruso Prof. Pasquale Longo Prof. Maria Stefania Sinicropi Prof. Carmela Saturnino 《ChemMedChem》2020,15(23):2306-2316
Cancer is going to be the first cause of mortality worldwide in the 21th century. It is considered a multifactorial disease that results from the combined influence of many genetic aberrations, leading to abnormal cell proliferation. As microtubules are strongly implicated in cellular growth, they represent an important target for cancer treatment. The well-known microtubule-targeting agents (MTAs) including paclitaxel, colchicine and vinca alkaloids are commonly used in the treatment of various cancers. However, adverse effects and drug resistance are major limitations in their clinical use. To find new candidates able to induce microtubule alteration with reduced toxic effects or drug resistance, we studied a small new series of derivatives that present imidazolinic, guanidinic, thioureidic and hydrazinic groups ( 1 – 9 ). All the compounds were tested for their antitumor activity against a panel of six tumoral cell models. In particular, compound 8 (nonane-1,9-diyl-bis-S-amidinothiourea dihydrobromide) showed the lowest IC50 value against HeLa cells, together with a low cytotoxicity for normal cells. This compound was able to induce the apoptotic mitochondrial pathway and inhibited tubulin polymerization with a similar efficacy to vinblastine and nocodazole. Taken together, these promising biological properties make compound 8 useful for the development of novel therapeutic approaches in cancer treatment. 相似文献
2.
3.
4.
对脱氢枞酸二乙烯三胺盐(Ⅱ)进行热重分析,提出了一种制备脱氢枞基咪唑啉(Ⅳ)的方法。将脱氢枞酸(Ⅰ)用带水剂二甲苯溶解,滴加到热的二乙烯三胺(DETA)中进行高温液液短接触脱水缩合反应,得到产品;DETA既是反应物,又是产品的不良溶剂,还起到调控反应温度的作用;二甲苯受热快速蒸发并将反应生成的水带离反应体系。反应结束后,该产品易于从反应混合物中冷却结晶析出、过滤分离,经元素分析、红外光谱、紫外光谱、1HNMR及13CNMR核磁共振谱的波谱结构表征确证。反应物料比可以改变反应体系的温度,进而对产品产率与外观色泽有较大的影响;在化合物Ⅰ的用量为30 mmol、DETA与化合物Ⅰ的物质的量之比为15.7、反应温度为210℃的条件下,产品产率为86.0%。 相似文献
5.
Synthesis,Corrosion Inhibition Performance and Biodegradability of Novel Alkyl Hydroxyethyl Imidazoline Salts 下载免费PDF全文
Hongqin Liu Jun Hu Xiaoze Zhou Dan Liu Baocai Xu Yawen Zhou 《Journal of surfactants and detergents》2015,18(6):1025-1031
New alkyl hydroxyethyl imidazoline salts were synthesized via a high pressure process with imidazoline and dimethyl carbonate, and their chemical structure were confirmed using mass spectral fragmentation and FTIR spectroscopic analysis. In addition, several quaternary ammonium salts with new counterions (formic acid, acetic acid and lactic acid) were also synthesized by ion exchange reaction of methyl carbonate quaternary ammoniums with the corresponding acids. These new compounds reduced the surface tension of water to a minimum value of approximately 27 mN m?1 at a concentration of 8.72 × 10?5 mol L?1. They also show efficient corrosion inhibition performances and could significantly inhibit the corrosion of mild steel in acid solutions. It was also found that the biological degradation of these imidazoline surfactants was greater than 98 % after 7 days. 相似文献
6.
7.
8.
针对油田注水开发过程中存在的腐蚀问题,合成了水溶性的咪唑啉类缓蚀剂LRX,利用静态挂片法和极化曲线法考察了其缓蚀性能。结果表明,在苯甲酸与二乙烯三胺的摩尔比为1∶1.4,咪唑啉中间体与氯乙酸的摩尔比1∶1.5,季铵化温度控制在60℃,反应时间4 h时,合成的咪唑啉类缓蚀剂LRX为阳极型缓蚀剂,对20#钢的缓蚀率达85%;合成的咪唑啉类缓蚀剂LRX与阻垢剂HEDP复配后,在缓蚀和阻CaCO3垢性能方面具有良好的协同效应。 相似文献
9.
10.