地域文化元素融入都江堰旅游产品的设计策略

目的 针对目前市面上都江堰旅游产品识别性较弱、同质化严重，对具有地域文化特色的旅游产品开发较少的问题，以地域文化元素作为都江堰旅游产品设计的核心，提出旅游产品的设计策略。方法 研究都江堰旅游产品设计，应从地域化和文化内涵入手。通过分析旅游产品现状，地域文化元素及新旅游时代背景下旅游产品的发展趋势，结合情感化设计理念，围绕用户体验进行探究，总结出都江堰旅游产品设计开发模式。以李冰石像和鱼嘴段水利工程元素为例，进行产品实践。结论 提出符合都江堰区域特色的旅游产品设计策略，即树立品牌意识、打造IP形象，以地域文化元素为设计核心，加强情感互动、与科技相融合的设计策略。赋予旅游产品更深层次的内涵，打造更多具有地域文化特色的旅游产品，从而推动历史文化与商业价值的融合，也能够为同类型旅游产品提供具有应用价值和参考的设计策略和思路。     

Modification of the wood-plastic composite for enhancement of formaldehyde clearance and the 3D printing application

As the formaldehyde is one of the main indoor pollutants, the purpose of this study is to effectively remove indoor formaldehyde pollution by using environmentally friendly 3D printing ornaments. The wood 3D printing filaments cellulose/polylactic acid composite (Cellu/P) was selected as the starting material, and 3-aminopropyltriethoxysilane (APTES) was used for chemical modification to obtain a series of cellulose composite materials with amino groups. The modified composite materials (APTES@Cellu/P) were characterized by Fourier transform infrared, X-ray diffraction, scanning electron microscope, energy dispersive spectroscopy, thermogravimetric analysis, and mechanical tests, and a formaldehyde removal experiment was performed. The feasibility of 3D printing was evaluated, and the process of 3D printing-functionalized customized ornaments was proposed, and then a school emblem was used for modeling, printing, and surface modification. Compared with the commercially traditional activated carbon, 3D printing-customized ornaments of APTES@Cellu/P material has a better formaldehyde removal effect, and can even avoid the secondary pollution that is common to the activated carbon.     

Effects of Electromagnetic Waves with LTE and 5G Bandwidth on the Skin Pigmentation In Vitro

With the rapid growth of wireless communication devices, the influences of electromagnetic fields (EMF) on human health are gathering increasing attention. Since the skin is the largest organ of the body and is located at the outermost layer, it is considered a major target for the health effects of EMF. Skin pigmentation represents one of the most frequent symptoms caused by various non-ionizing radiations, including ultraviolet radiation, blue light, infrared, and extremely low frequency (ELF). Here, we investigated the effects of EMFs with long-term evolution (LTE, 1.762 GHz) and 5G (28 GHz) bandwidth on skin pigmentation in vitro. Murine and Human melanoma cells (B16F10 and MNT-1) were exposed to either LTE or 5G for 4 h per day, which is considered the upper bound of average smartphone use time. It was shown that neither LTE nor 5G exposure induced significant effects on cell viability or pigmentation. The dendrites of MNT-1 were neither lengthened nor regressed after EMF exposure. Skin pigmentation effects of EMFs were further examined in the human keratinocyte cell line (MNT-1-HaCaT) co-culture system, which confirmed the absence of significant hyper-pigmentation effects of LTE and 5G EMFs. Lastly, MelanoDerm™, a 3D pigmented human epidermis model, was irradiated with LTE (1.762 GHz) or 5G (28 GHz), and image analysis and special staining were performed. No changes in the brightness of MelanoDerm™ tissues were observed in LTE- or 5G-exposed tissues, except for only minimal changes in the size of melanocytes. Collectively, these results imply that exposure to LTE and 5G EMFs may not affect melanin synthesis or skin pigmentation under normal smartphone use condition.     

Studies on waterline corrosion processes and corrosion product characteristics of carbon steel in 3.5 wt% NaCl solution

The waterline corrosion behaviors of carbon steel partially immersed in a 3.5 wt% NaCl solution were investigated using the wire beam electrode technique, and the effects of corrosion products on the processes of waterline corrosion were analyzed. The results demonstrated that the initial stage and development stage of waterline corrosion were mainly controlled by the concentration and diffusion of dissolved oxygen, respectively, and the deceleration stage of waterline corrosion was mainly affected by corrosion products. The main component of the yellow corrosion products was γ-FeOOH, and γ-FeOOH that exhibited a high reduction reactivity could be involved in the cathodic reaction. The black corrosion products were mainly composed of Fe₃O₄ with strong thermodynamic stability and the processes of dissolved oxygen diffusion and ion transports were obviously affected due to the continuous accumulation of Fe₃O₄ on the surface of the electrodes. Polarity reversals were observed on the single electrodes below the waterline, but the reasons for the phenomena were different from each other.     

Oil Demand and Stocks

Current data of world oil demand. This includes international bunkers and refinery fuel. Updated on a monthly basis. Current data of oil demand from counties such as Canada, the United States of America, Japan, OECD Europe, Belgium, France, Germany, Italy, Netherlands, Spain, Sweden, the United Kingdom, Australia, Mexico, Republic of Korea, and Turkey. Updated on a monthly basis. Current data for crude oil and refined product stocks in Canada, Chile, Mexico, the United States (Western Hemisphere), France, Germany, Italy, Netherlands, Spain, the United Kingdom and Other Europe (Europe), Japan, Republic of Korea, Other Pacific (Asia‐Pacific), and Total OECD (Table 12.1) Current data for refined product stocks in the OECD Western Hemisphere, OECD Europe, OECD Asia‐Pacific and Total OECD. Products include gasoline, diesel and gasoil, and heavy fuel oil. Updated on a monthly basis (Table 12.2).     

Development of Phosphodiesterase–Protein-Kinase Complexes as Novel Targets for Discovery of Inhibitors with Enhanced Specificity

Phosphodiesterases (PDEs) hydrolyze cyclic nucleotides to modulate multiple signaling events in cells. PDEs are recognized to actively associate with cyclic nucleotide receptors (protein kinases, PKs) in larger macromolecular assemblies referred to as signalosomes. Complexation of PDEs with PKs generates an expanded active site that enhances PDE activity. This facilitates signalosome-associated PDEs to preferentially catalyze active hydrolysis of cyclic nucleotides bound to PKs and aid in signal termination. PDEs are important drug targets, and current strategies for inhibitor discovery are based entirely on targeting conserved PDE catalytic domains. This often results in inhibitors with cross-reactivity amongst closely related PDEs and attendant unwanted side effects. Here, our approach targeted PDE–PK complexes as they would occur in signalosomes, thereby offering greater specificity. Our developed fluorescence polarization assay was adapted to identify inhibitors that block cyclic nucleotide pockets in PDE–PK complexes in one mode and disrupt protein-protein interactions between PDEs and PKs in a second mode. We tested this approach with three different systems—cAMP-specific PDE8–PKAR, cGMP-specific PDE5–PKG, and dual-specificity RegA–R_D complexes—and ranked inhibitors according to their inhibition potency. Targeting PDE–PK complexes offers biochemical tools for describing the exquisite specificity of cyclic nucleotide signaling networks in cells.     

Flexible electronic skin with high performance pressure sensing based on PVDF/rGO/BaTiO3 composite thin film

The wearable intelligent electronic product similar to electronic skin has a great application prospect. However, flexible electronic with high performance pressure sensing functions are still facing great challenges. In this paper, the highly sensitive flexible electronic skin (FES) based on the PVDF/rGO/BaTiO₃ composite thin film was fabricated using the near-field electrohydrodynamic direct-writing (NFEDW) method. The PVDF/rGO/BaTiO₃ composite solution was directly written on flexible substrate by the NFEDW method to fabricate FES with micro/nano fiber structure, which has the function of sensing pressure with high sensitivity and fast response. The surface morphology and microstructure were characterized by SEM, AFM, and optical microscope in detail. The fabricated FES has high sensitivity (59 kPa⁻¹) and faster response time (130 ms). FES has been successfully applied to the detection of human motion and subtle physiological signals. The experimental results show that FES has good stability and reliability. FES can recognize human motion, and it has a broad application prospect in the field of wearable devices.     

Microstructure evolution of CMAS glass below melting temperature and its potential influence on thermal barrier coatings

CaO–MgO–Al₂O₃–SiO₂ (CMAS) deposition significantly degrades the performance of thermal barrier coatings (TBCs). In this study, the microstructure evolution of CMAS glass at temperatures below its melting point was investigated in order to study the potential influence of temperature on the applicability of CMAS glass in TBCs. The CMAS glass fabricated in this study had a melting point of 1240 °C, became opaque, and underwent self-crystallization when the temperature reached 1000 °C. After heat treatment at 1050 °C, diopside and anorthite phases precipitated from the glass; at a higher temperature (1150 °C), diopside, anorthite, and wollastonite were formed as the self-crystallization products. An increase in the dwelling time resulted in the transformation of diopside to wollastonite and anorthite. At 1250 °C, all products formed a eutectic microstructure and melted. The results indicate that even at low temperatures, CMAS glass underwent microstructure evolution, which could influence the coating surface and stress distribution when deposited on TBCs.     

副溶血性弧菌多克隆抗体制备及应用

以热灭活副溶血性弧菌(Vibrio parahaemolyticus,VP ATCC17802)免疫新西兰大白兔制备多克隆抗体,用间接酶联免疫吸附法测定抗血清效价,纯化后的多克隆抗体效价为512000。该抗体与5株副溶血性弧菌均能特异性结合,但与其他12株非副溶血性弧菌无交叉反应。在此基础之上建立了间接竞争酶联免疫吸附法(indirect competitive enzyme-linked immunosorbent assay,ic-ELISA),并优化了抗原抗体浓度、二抗浓度、封闭液等条件。结果表明,该法的线性范围为5×10^4~107CFU/m L,线性回归方程为y=0.21x-0.74(R2=0.99),IC50为106CFU/m L,最低检出限为1.7×10^4CFU/m L,板内变异系数为2.61%~4.15%,板间变异系数为4.71%~8.74%。用建立的ic-ELISA检测市场中鱼、贝类养殖水和实验室用水中的VP,实验结果与国标检测方法的结果一致。该方法快速便捷,灵敏度高,准确性好,为进一步研究VP的快速检测奠定了基础。     

发用类、肤用清洁类化妆品的急性皮肤和眼刺激损害特点

分析发用类、肤用清洁类化妆品的急性皮肤刺激和急性眼刺激损害特点,了解其卫生安全状况。于2012年采用《化妆品卫生规范》(2007年版)中的急性皮肤刺激性实验和急性眼刺激性实验对发用类、肤用清洁类共计158种化妆品样品进行测试。两类受试化妆品显示出不同程度的急性皮肤刺激性和急性眼刺激性损害效应。发用类化妆品在实验中基本无皮肤刺激性损伤;肤用清洁类化妆品在实验中有少量的皮肤刺激性损伤,但大都为轻刺激性(31.0%),只有个别(3.8%)出现了皮肤红斑水肿的中刺激性损伤。发用类、肤用清洁类化妆品在急性眼刺激性实验中检出一定比例具有微刺激性及以上刺激性的样品,但引起的眼损伤都能够在观察期限内恢复。本次调查的所有化妆品中,洁面类、洗发类化妆品普遍具有急性眼刺激性和急性皮肤刺激性损害,需加强对化妆品的监督管理,进一步提升化妆品卫生安全水平,保障化妆品使用安全。