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为了寻找抗菌候选化合物,采用基于片段的药物发现方法,以氨基膦酸酯和磺酰氯为原料,设计合成了15个含膦酸酯结构单元的磺胺衍生物,经IR、1HNMR和13CNMR确认结构。采用两倍稀释法测定目标化合物的MIC(最小抑菌浓度)。结果表明:部分目标化合物呈潜在的抗菌活性,对所测试标准菌和耐药菌均有抑制活性。其中,化合物Ⅱf〔N-[(二乙氧基膦酰基)-4-氟苯甲基]-4-甲氧基苯磺酰胺〕对金黄色葡萄球菌(S. aureus)、大肠埃希菌(E. coli)、耐甲氧西林金黄色葡萄球菌(MRSA)及耐氟喹诺酮类大肠杆菌(MREC)的MIC分别为32、64、128和128μg/mL,化合物Ⅱl〔N-[(二乙氧基膦酰基)-4-氟苯甲基]-4-氟苯磺酰胺〕对S. aureus、E. coli、MRSA及MREC的MIC分别为32、32、64和64μg/mL,抗菌活性优于对照药磺胺嘧啶。 相似文献
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2-氯苯磺胺新工艺研究 总被引:2,自引:0,他引:2
2 氯苯磺胺是除草剂氯磺隆的中间体 ,本文开发了合成 2 氯苯磺胺的新工艺 ,用邻二氯苯为起始原料 ,经硫化、氧化性氯化和氨化反应生成磺胺 ,产品纯度可达到 95 %~ 96 % ,收率为 4 6 %。探讨了各种反应条件对反应产率的影响 ,并利用GC/MS分析氧化性氯化反应中间产物的结构。 相似文献
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为进一步扩展聚酰胺6织物的应用领域,采用磺胺作为阻燃整理剂,在高温条件下,通过浸渍沉积法对聚酰胺6织物进行阻燃防熔滴整理。并对整理后聚酰胺6织物的热稳定性、热释放性能、抗熔滴性能、阻燃性能和阻燃机制进行分析。结果表明:经磺胺阻燃整理后,聚酰胺6织物的极限氧指数达到32.2%,损毁长度和损毁面积均减小,无熔滴产生,达到阻燃B1级的要求,具有较好的阻燃效果;同时整理后聚酰胺6织物的最大热释放速率下降了16.9%,火灾危害性显著降低;磺胺主要通过气相阻燃机制提高聚酰胺6织物的阻燃性能,且阻燃整理对聚酰胺6织物的强力和手感影响较小。 相似文献
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Tomasz Jeliński Maciej Przybyłek Piotr Cysewski 《Drug development and industrial pharmacy》2013,39(7):1120-1129
Objective: The aim of this study was to explore the possibility of using natural deep eutectic solvents (NADES) as solvation media for enhancement of solubility of sulfonamides, as well as gaining some thermodynamic characteristics of the analyzed systems.Significance: Low solubility of many active pharmaceutical ingredients is a well-recognized difficulty in pharmaceutical industry, hence the need for different strategies addressing this problem. Among such strategies, those that are environmentally and economically beneficial are of particular interest.Methods: The solubility of sulfanilamide and sulfacetamide in 21 different NADES compositions comprising choline chloride with sugars or sugar alcohols was measured spectrophotometrically. Thermodynamic parameters describing the studied systems were determined using the COSMO-RS computational protocol.Results: All of the considered NADES compositions gave an increase in solubility of the studied sulfonamides, with the highest solubilities obtained for the system comprising choline chloride and glycerol in unimolar proportions, which gave a solubility advantage of 83.7 and 73.8 for sulfanilamide and sulfacetamide, respectively. Theoretical studies indicated that the dissolution of both considered sulfonamides has a low endothermic character, with the lowest enthalpy values obtained for the most optimal, i.e. unimolar, proportions. The non-monotonous trend of enthalpy of dissolution was also discussed in terms of intermolecular interactions.Conclusions: The obtained results show the feasibility of using NADES as solubility enhancers for sulfonamides and encourage for further exploration in this field. 相似文献
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合成了DTPA-2SN(二乙烯三胺二乙酰二磺胺),并对其化学结构进行了鉴定;制备了DTPA双酸酐(DTPAA),通过DTPAA与磺胺反应合成DTPA-2SN,并对其进行了99Tcm标记。采用n(K222):n( K2CO3)薄层层析法测定标记率,Sep-Pak C18小柱纯化,鉴定放化纯度。并观察其体外稳定性。结果显示DTPAA产率为85%,DTPA-2SN的产率为80%,二者经鉴定与其化学结构式相符。DTPA-2SN易于被99Tcm标记,标记率可达90%±3%。连续观察4h 99Tcm-DTPA-2SN放化纯度均大于90%,稳定性良好。 相似文献
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以对氨基苯磺酰胺、双氧水和盐酸为原料合成3,5-二氯对氨基苯磺胺,研究了原料配比、催化剂AlCl3的滴加方式、H2O2的滴加时间对收率的影响,得出最佳工艺条件为:n(Q6N2O2S):n(30%HCl质量分数):1:13.7,7g AlCl3晶体溶于剩余的盐酸中,于H2O2滴加一半时加入,H2O2的滴加时间为40min。产品的收率可达81.O%,熔点为204—205.5℃。 相似文献