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1.
Multiple lines of evidence support the pathogenic role of maternal immune activation (MIA) in the occurrence of the schizophrenia-like disturbances in offspring. While in the brain the homeostatic role of neuron-microglia protein systems is well documented, the participation of the CX3CL1-CX3CR1 and CD200-CD200R dyads in the adverse impact of MIA often goes under-recognized. Therefore, in the present study, we examined the effect of MIA induced by polyinosinic:polycytidylic acid (Poly I:C) on the CX3CL1-CX3CR1 and CD200-CD200R axes, microglial trajectory (MhcII, Cd40, iNos, Il-1β, Tnf-α, Il-6, Arg1, Igf-1, Tgf-β and Il-4), and schizophrenia-like behaviour in adult male offspring of Sprague-Dawley rats. Additionally, according to the “two-hit” hypothesis of schizophrenia, we evaluated the influence of acute challenge with Poly I:C in adult prenatally MIA-exposed animals on the above parameters. In the present study, MIA evoked by Poly I:C injection in the late period of gestation led to the appearance of schizophrenia-like disturbances in adult offspring. Our results revealed the deficits manifested as a diminished number of aggressive interactions, presence of depressive-like episodes, and increase of exploratory activity, as well as a dichotomy in the sensorimotor gating in the prepulse inhibition (PPI) test expressed as two behavioural phenotypes (MIAPPI-low and MIAPPI-high). Furthermore, in the offspring rats subjected to a prenatal challenge (i.e., MIA) we noticed the lack of modulation of behavioural changes after the additional acute immune stimulus (Poly I:C) in adulthood. The important finding reported in this article is that MIA affects the expression and levels of the neuron-microglia proteins in the frontal cortex and hippocampus of adult offspring. We found that the changes in the CX3CL1-CX3CR1 axis could affect microglial trajectory, including decreased hippocampal mRNA level of MhcII and elevated cortical expression of Igf-1 in the MIAPPI-high animals and/or could cause the up-regulation of an inflammatory response (Il-6, Tnf-α, iNos) after the “second hit” in both examined brain regions and, at least in part, might differentiate behavioural disturbances in adult offspring. Consequently, the future effort to identify the biological background of these interactions in the Poly I:C-induced MIA model in Sprague-Dawley rats is desirable to unequivocally clarify this issue.  相似文献   
2.
Offshore cranes are complicated underactuated systems, which work in harsh sea conditions. Due to the various severe disturbances, the control of offshore cranes has always been a great challenge, which is made even more complicated when considering some practical issues such as actuator saturation and coordination. Until now, few results have been published in the literature on this topic. To address this problem, an efficient nonlinear control method is proposed for offshore boom cranes suffering from both ship roll and heave motion in this paper, which takes full consideration of actuator saturation, as well as the coordination problem between actuators. Furthermore, regarding the various extra nonvanishing disturbances, such as winds, frictions, and unmodeled dynamics, a disturbance observer is designed to estimate and eliminate these uncertainties. The asymptotic stability of the desired equilibrium point is rigorously guaranteed by Lyapunov techniques and LaSalle's invariance theorem. Finally, extensive hardware experimental tests are carried out to demonstrate the feasibility and efficiency of the proposed method. To the best of our knowledge, this paper proposes the first method that considers the saturation and coordination problem for offshore cranes while guaranteeing the asymptotic stability of the desired equilibrium point.  相似文献   
3.
In spite of the huge progress in the treatment of diabetes mellitus, we are still in the situation that both pregestational (PGDM) and gestational diabetes (GDM) impose an additional risk to the embryo, fetus, and course of pregnancy. PGDM may increase the rate of congenital malformations, especially cardiac, nervous system, musculoskeletal system, and limbs. PGDM may interfere with fetal growth, often causing macrosomia, but in the presence of severe maternal complications, especially nephropathy, it may inhibit fetal growth. PGDM may also induce a variety of perinatal complications such as stillbirth and perinatal death, cardiomyopathy, respiratory morbidity, and perinatal asphyxia. GDM that generally develops in the second half of pregnancy induces similar but generally less severe complications. Their severity is higher with earlier onset of GDM and inversely correlated with the degree of glycemic control. Early initiation of GDM might even cause some increase in the rate of congenital malformations. Both PGDM and GDM may cause various motor and behavioral neurodevelopmental problems, including an increased incidence of attention deficit hyperactivity disorder (ADHD) and autism spectrum disorder (ASD). Most complications are reduced in incidence and severity with the improvement in diabetic control. Mechanisms of diabetic-induced damage in pregnancy are related to maternal and fetal hyperglycemia, enhanced oxidative stress, epigenetic changes, and other, less defined, pathogenic mechanisms.  相似文献   
4.
A robust adaptive tracking control scheme is presented for a class of multiple‐input and multiple‐output mechanical systems with unknown disturbances under actuator saturation. The unknown disturbances are expressed as the outputs of a linear exogenous system with unknown coefficient matrices. An adaptive disturbance observer is constructed for the online disturbance estimation. An actuator saturation compensator is introduced to attenuate the adverse effects of actuator saturation. The adaptive backstepping method is then applied to design the robust adaptive tracking control law. It is proved that the designed control law makes the system outputs track the desired trajectories and guarantees the global uniform ultimate stability of the closed‐loop control system. Simulations on a two‐link robotic manipulator verify the effectiveness of the proposed control scheme.  相似文献   
5.
魏新江  张玲艳 《控制与决策》2016,31(9):1697-1701

针对一类带有干扰的非线性严格反馈系统, 研究其抗干扰控制问题. 系统干扰满足不匹配条件, 代表一类部分信息已知的干扰. 通过设计非线性干扰观测器, 提出基于非线性干扰观测器和back-stepping 的抗干扰控制方法来补偿干扰, 该方法可以保证闭环系统所有信号是半全局最终一致有界的. 最后, 通过与现有方法的对比验证了所提出方法的正确性和有效性.

  相似文献   
6.
This article considers the design of interval functional observers to estimate a linear function of the state vector of time-delay systems subject to both input and output additive disturbances. Two novel functional observers are proposed and designed such that they bound the set of all admissible values of a linear function of the state vector at each instant of time. By contrast to interval observers currently available in the literature, both observers proposed in this article utilize multiple delayed output measurement and have a more general structure. This trade-off feature overcomes some drawbacks in previous work and enables interval functional observers to be designed for a wider class of time-delay systems. Conditions for the existence of interval functional observers are derived and an effective design algorithm for computing unknown observer matrices is provided. Two illustrative examples are given to show the advantages and effectiveness of our design method.  相似文献   
7.
采用改进多分辨率快速S变换的电能质量扰动识别   总被引:1,自引:0,他引:1  
噪声干扰是影响电能质量暂态扰动识别准确率的最重要因素。经过S变换后获得的扰动信号的模时–频矩阵具有灰度图像特点。因此,可通过二维数学形态学方法,滤除噪声干扰,获得更高的识别准确率。首先,针对扰动信号时–频分布特点,设计具有不同时–频分辨率的多分辨率快速S变换方法以降低运算量、提高特征表现能力;之后,在阈值滤波基础上,根据信号时–频分布特点,选择线段型、零角度结构元进行灰度级形态学开运算,进一步滤除高频频域噪声;最后,从原始信号、信号傅里叶谱、多分辨率快速S变换模矩阵中提取5种特征建立决策树分类器,识别含噪声信号与6种复合扰动信号在内的12种电能质量信号。通过仿真对比实验发现,新方法具有更好的抗噪能力,更加适用于低信噪比环境下的电能质量信号识别。  相似文献   
8.
This paper proposes a novel sag/swell detection algorithm based on wavelet transform (WT) operating even in the presence of flicker and harmonics in source voltage. The developed algorithm is the hybrid of Daubechies wavelets of order 2 (db2) and order 8 (db8) to detect voltage sag/swell with and without positive/negative phase jumps. The hybrid detection algorithm can detect the start and end times of voltage sag/swell with and without phase jumps within 0.5 ms and 1.15 ms, respectively. The performance of the proposed voltage sag/swell detection method is compared with the results of dq-transformation, Fast Fourier Transform (FFT) and Enhanced Phase Locked Loop (EPLL) based voltage sag/swell detection methods. The good robustness and faster processing time to detect balanced and unbalanced voltage sag/swell are provided using proposed method. With the proposed hybrid detection algorithm consisting of db2 and db8 wavelet functions, a robust sag/swell detection is achieved which can give precise and quick response. The performance of proposed hybrid algorithm is validated and confirmed through simulation studies using the PSCAD/EMTDC analysis program.  相似文献   
9.
行波扰动对天波雷达慢速目标检测影响研究   总被引:1,自引:0,他引:1  
利用电离层行波扰动(Traveling Ionospheric Disturbances,TIDs)模型,仿真分析了不同尺度TIDs引起的超视距雷达(Over the Horizon Radar,OTHR)地海杂波频谱频移、展宽以及对舰船目标检测的影响.结果表明:小尺度TIDs引起的附加多普勒频移幅度较小,但随时间变化较快,S形曲线扭曲较为严重,对OTHR影响主要表现为多普勒频移;中尺度和大尺度TIDs引起的附加多普勒频移相对于小尺度TIDs的有所增加,但随时间变化减缓,S形曲线扭曲程度减小,除引起地海杂波多普勒频移外,同时引起杂波频谱展宽,影响舰船目标检测.同时,还给出了不同尺度TIDs引起的海杂波频移、展宽抑制方法,经仿真验证,上述算法有效.  相似文献   
10.
杨杰  曹君利  刘鹤 《金属学报》2022,27(12):1322-1332
无创神经调控技术是主要通过电刺激、磁刺激等对神经功能状态进行调控的一种非侵入性、安全、便捷的有效治疗手段。近年来,无创神经调控技术越来越多地被用于脑功能调控的相关研究和治疗,其在脑卒中患者的认知障碍调控、抑郁、焦虑、谵妄、失眠等神经精神疾病的治疗上都有相关研究证实。临床科室如神经内科、康复科、疼痛科等多学科都广泛运用无创神经调控这一技术,但其在围术期的应用较少,尤其是针对全麻患者术后睡眠功能紊乱的研究尚未见报道。术后睡眠功能紊乱是术后一个常见且容易被忽视的并发症,常表现为术后睡眠结构紊乱、睡眠质量下降、睡眠时长明显缩短等,全身麻醉患者术后睡眠功能更容易受影响。术后睡眠功能紊乱涉及术前、术中以及术后等很多影响因素,影响患者整个围术期甚至出院后的长期预后。  相似文献   
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