Xanthohumol for Human Malignancies: Chemistry,Pharmacokinetics and Molecular Targets

Xanthohumol (XH) is an important prenylated flavonoid that is found within the inflorescence of Humulus lupulus L. (Hop plant). XH is an important ingredient in beer and is considered a significant bioactive agent due to its diverse medicinal applications, which include anti-inflammatory, antimicrobial, antioxidant, immunomodulatory, antiviral, antifungal, antigenotoxic, antiangiogenic, and antimalarial effects as well as strong anticancer activity towards various types of cancer cells. XH acts as a wide ranging chemopreventive and anticancer agent, and its isomer, 8-prenylnaringenin, is a phytoestrogen with strong estrogenic activity. The present review focuses on the bioactivity of XH on various types of cancers and its pharmacokinetics. In this paper, we first highlight, in brief, the history and use of hops and then the chemistry and structure–activity relationship of XH. Lastly, we focus on its prominent effects and mechanisms of action on various cancers and its possible use in cancer prevention and treatment. Considering the limited number of available reviews on this subject, our goal is to provide a complete and detailed understanding of the anticancer effects of XH against different cancers.     

煤峪口矿81010工作面煤层底板裂隙发育特征及防治

针对煤炭开采过程中出现的突水事故,采用RFPA数值模拟软件建立采动模型,对底板裂隙破断过程和声发射进行模拟,研究煤层底板采动裂隙扩展突水通道,结果表明:离断层越近,断层内水压导升高度越高,断层出现活化,裂隙扩展发育,最终贯通形成导水通道,在进行注浆改造后,单个钻孔的最大涌水量为8 m³/h,说明注浆加固防治水效果较好,能确保工作面的安全回采。     

某燃机热电减温水喷嘴频繁堵塞原因分析及防治措施

某燃气轮机电站运行中制冷站减温水喷嘴频繁堵塞,喷嘴需经常人工清理,管道输送泵压力、频率和开度增大,电耗增加,严重影响制冷机系统正常运行状态。通过现场系统查定、减温水水质分析、堵塞物能谱分析等技术手段,分析发生异常现象的原因并得出初步结论,并针对性提出合理有效的防治措施。     

横山北部区域防漏堵漏技术现场应用成果

随着中国经济不断发展,石油的使用频率逐渐在增加。在石油开发过程中,新的技术和工艺也在发展中不断被使用,从而推动提高了石油的开发效率和开发质量。在石油开发过程中,只有及时了解钻井施工现场的情况,才能够减少施工中出现的风险,从而减少钻井施工的经济损失。通过分析井漏危害,了解进行防漏堵漏工作的必要性,进一步分析横山北部区域漏失原因,并针对该区域目前的现状,提出推后工艺堵漏、调整钻井液性能、随钻堵漏和分钻堵漏四种堵漏措施,在横山北部区域实施后,取得了较好结果。     

爆炸防控技术在爆破工程警务规划和技术评估中应用

通过介绍爆炸防控技术概念的内涵和外延,说明了爆破工程警务规划设计和技术评估的目的,就是有效防止或遏制涉爆事故,维护社会公共安全。在对一项复杂环境下的基础开挖爆破工程实施警务规划设计和技术评估时,警务技术民警对照爆破作业设计施工单位技术方案中的参数,现场核实需要保护的建筑和重要设施,准确测量保护目标与爆区的实际距离,分析是否存在影响爆破工程实施的不稳定因素,确认上述参数符合安全要求后做出准予爆破许可的建议。爆破工程警务规划设计和技术评估的要点就是要通过现场核查,核实爆破有害效应是否可控,能否确保爆破施工时周边保护目标的安全。     

Research on paraffin removal and prevention by Bacillus spp. in high-salinity reservoirs

Problems in paraffin deposition occur frequently in oil exploitation. Considering the problem that some paraffin removal and prevention strains cannot grow in high-salinity reservoirs, we domesticated four salt-tolerant laboratory bacterial strains. Crude oil emulsification effect, paraffin removal rate, and paraffin prevention rate of the strains were evaluated. KB and JH-A strains exhibited good paraffin removal and prevention effects, with paraffin removal rates of 51.82% and 81.56%; and 51.82% and 80.90%, respectively. Gas chromatography mass spectrometry analysis of paraffin components before and after biodegradation was performed on KB and JH-A strains. Results showed that relative contents of n-alkanes between C15–C23 and C27–C30 evidently decreased, indicating their good biodegradation. This technique provides a new method for practical application of paraffin removal and prevention in high-salinity reservoirs.     

不同工艺山茶油预防胃肠炎、胃溃疡的研究

以不同工艺山茶油为研究对象,比较其对SD大鼠胃肠炎、胃溃疡的预防作用。结果表明:鲜榨山茶油、原香山茶油、精炼山茶油对大鼠胃肠炎、胃溃疡均有一定的预防作用,整体效应是原香山茶油、鲜榨山茶油优于精炼山茶油;在大鼠胃液白细胞数、胃和十二指肠病理变化的调节作用中,鲜榨山茶油又优于原香山茶油。     

井下均压通风防灭火分析

以井下均压通风防灭火为对象开展探究。结合具体工程实际,在分析煤层自燃风险性的基础上,探究了均压通风防灭火的原理,并总结了均压通风防灭火技术的实践应用。结果表明,均压通风防灭火技术的应用实现了对采空区遗煤自燃的有效防治,对提升矿井作业安全性效果显著。     

近距离煤层群采空区漏风规律及防控措施研究

贵州地区煤层赋存条件复杂,煤层间距小,相邻采空区存在漏风通道的问题。采用SF6示踪法及重点区域指标气体数据分析法,对发耳煤矿采空区漏风规律及其治理措施进行研究。分析结果表明,由于相邻密闭效果欠佳,导致31004开切眼联络巷及31004工作面回风巷密闭漏风严重。31004采空区漏风通道主要是31004开切眼联络巷密闭及10^#煤层开采过程中对上部7^#煤层采空区造成二次扰动形成的纵向漏风通道;漏风量为83 m^3/min,采空区风速约为0.17 m/s。对存在的煤自燃隐患采取了注水降温措施,CO体积分数显著下降至(5~9)×10^-6。为即将开采的50105、50107工作面的煤自燃防控提供了科学依据和管控措施方案。     

煤矿冲击矿压预测和防治技术浅析

结合镇城底煤矿22605工作面的地质情况和矿压情况,提出了煤炭生产中冲击矿压的预测和防治措施。通过对22605工作面的地质情况和监测数据分析处理并探究了该工作面矿压显现规律,为其设计了一套适合本工作面的冲击矿压监测和防治体系。防治体系有预防和临时解危双重防治措施,从这两方面考虑可以做到全面防治冲击矿压。该体系可以实现矿井的安全生产,保证工作人员的安全。另通过分析冲击矿压发生的基本原理和监测到的数据,建立煤矿冲击矿压防治体系,能够及时有效地将蕴含在煤体中的冲击矿压释放和消除,达到安全生产的目的。