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1.
M. R. Thompson 《Drug development and industrial pharmacy》2015,41(8):1223-1231
Twin screw granulation (TSG) is a new process of interest to the pharmaceutical community that can continuously wet granulate powders, doing so at lower liquid concentrations and with better product consistency than found by a high shear batch mixer. A considerable body of research has evolved over the short time since this process was introduced but generally with little comparison of results. A certain degree of confidence has been developed through these studies related to how process variables and many attributes of machinery configuration will affect granulation but some major challenges still lay ahead related to scalability, variations in the processing regimes related to degree of channel fill and the impact of wetting and granulation of complex powder formulations. This review examines the current literature for wet granulation processes studied in twin screw extrusion machinery, summarizing the influences of operational and system parameters affecting granule properties as well as strives to provide some practical observations to newly interested users of the technique. 相似文献
2.
加固改造中的结构承重体系转换 总被引:2,自引:0,他引:2
从加固改造工程的实践出发 ,探讨了混合结构向框架结构体系转换的方法和构造措施 ,为实际工程提供了新的技术思路 相似文献
3.
就用双辊铸轧机(TRC)生产薄、宽铸轧带技术进行研究并优化铸轧工艺。研究结果表明:3mm厚的铸轧带不仅表面变形.而且整个厚度内部层都发生变形,表面层的铝基中具有较高的合金元素饱和度。 相似文献
4.
双螺杆反应挤出模型的研究 总被引:5,自引:0,他引:5
详细研究了双螺杆中反应挤出聚合物的动力学模型、流动模型和传热模型。通过实验得到了双螺杆反应器中聚合物的停留时间分布及平均停留时间。 相似文献
5.
根据啮合型同向旋转双螺杆挤出非充满熔融的理论模型,对描述非充满熔融过程的主要物理量:固相高度变化函数、熔融速率及熔融区总长等进行了计算分析,并对有关影响因素进行了讨论。 相似文献
6.
Cyber-physical production systems enable adaptivity and flexibility when manufacturing customized products in small batches. Due to varying routes and a high variance of workpieces, material flows in cyber-physical production systems can get highly complex, which can lead to physically induced disturbances that can result in accidents or decreased throughput and high costs. This issue can be addressed by applying a physics engine to simulate the physical interaction between workpieces and the material handling systems during the operation. Connecting such a digital model to a real material handling system in order to derive simulation-based decision support leads to the concept of digital twins. To date, few practical implementations of digital twins in manufacturing outside the machine tool domain were reported. Therefore, this paper describes the modeling and the subsequent implementation of an integrated system that consists of a real material handling system and its digital twin, based on physics simulation. A practical use case demonstrates the versatile advantages of the implemented solution for a manufacturing system with respect to the three digital twin functions prediction, monitoring and diagnosis. 相似文献
7.
Computer Numerical Control Machine Tool (CNCMT) Digital Twin (DT) model is a carrier for complex, time-varying, coupled data of CNCMT, which can theoretically provide a time-varying high-fidelity model. However, there are still many difficulties in its implementation process. And the key issue is how to realize the updated DT model with performance attenuation and validate it. In order to solve this problem, a model consistency retention method for CNCMT DT model is studied and proposed in this paper. Firstly, the framework of consistency retention method for DT model is designed including both digital space and physical space. The principles of data management and performance attenuation update in digital space are elaborated. Then, the implementation method for consistency retention of CNCMT DT model is studied in terms of performance attenuation update workflow for wear and other damage separately. Finally, a case study for the establishment and application of high-fidelity test bench DT model that focusing on rolling guide-rail is carried out to show the implementation flow of the proposed method and verify its operability and effectiveness. 相似文献
8.
Digital twin represents a fusion of the informational and physical domains, to bridge the material and virtual worlds. Existing methods of digital twin modeling are mainly based on modular representation, which limits guidance of the modeling process. Such methods do not consider the components or operational rules of the digital twin in detail, thereby preventing designers from applying these methods in their fields. With the increasing application of digital twin to various engineering fields, an effective method of modeling a multi-dimensional digital twin at the conceptual level is required. To such an end, this paper presents a method for the conceptual modeling of a digital twin based on a five-dimensional digital twin framework to represent the complex relationship between digital twin objects and their attributes. The proposed method was used to model the digital twin of an intelligent vehicle at the concept level. 相似文献
9.
Big data is one of the most important resources for the promotion of smart customisation. With access to data from multiple sources, manufacturers can provide on-demand and customised products. However, existing research of smart customisation has focused on data generated from the physical world, not virtual models. As physical data is constrained by what has already occurred, it is limited in the identification of new areas to improve customer satisfaction. A new technology called digital twin aims to achieve this integration of physical and virtual entities. Incorporation of digital twin into the paradigm of existing data-driven smart customisation will make the process more responsive, adaptable and predictive. This paper presents a new framework of data-driven smart customisation augmented by digital twin. The new framework aims to facilitate improved collaboration of all stakeholders in the customisation process. A case study of the elevator industry illustrates the efficacy of the proposed framework. 相似文献
10.
High-performance aerospace component manufacturing requires stringent in-process geometrical and performance-based quality control. Real-time observation, understanding and control of machining processes are integral to optimizing the machining strategies of aerospace component manufacturing. Digital Twin can be used to model, monitor and control the machining process by fusing multi-dimensional in-context machining process data, such as changes in geometry, material properties and machining parameters. However, there is a lack of systematic and efficient Digital Twin modeling method that can adaptively develop high-fidelity multi-scale and multi-dimensional Digital Twins of machining processes. Aiming at addressing this challenge, we proposed a Digital Twin modeling method based on biomimicry principles that can adaptively construct a multi-physics digital twin of the machining process. With this approach, we developed multiple Digital Twin sub-models, e.g., geometry model, behavior model and process model. These Digital Twin sub-models can interact with each other and compose an integrated true representation of the physical machining process. To demonstrate the effectiveness of the proposed biomimicry-based Digital Twin modeling method, we tested the method in monitoring and controlling the machining process of an air rudder. 相似文献