微通道电泳芯片系统中信号识别算法的设计与实现

介绍适用于微通道电泳芯片系统的DNA测序软件的总体流程，以及其中的信号处理与识别算法。以激光诱导荧光检测系统所采集到的原始数据为源信号，以小波平滑和小波去噪为理论基础，将滤波算法和峰值识别算法综合在一起进行设计，从而使其适用于检测速度更快、样品量更少的微通道电泳芯片系统。将本算法应用于DNA片段的分离实验中，可以有效地达到滤波以及信号识别的目的。     

Liquid Impact Based Material Micro-Forming Technology

The objective of this study was to investigate material deformation in the course of a high-speed (>1500 m/s) water impact and to use the acquired knowledge for improvement of the forming technology. An experimental setup for projectile fabrication was constructed and a series of experiments involving sub-millimeter and micron scale metal deformation was performed. The geometry and topography of the generated samples were investigated using advanced surface examination techniques and the feasibility of the liquid impact based micro-forming technology was demonstrated. This article was presented at Materials Science & Technology 2006, Innovations in Metal Forming symposium held in Cincinnati, OH, October 15-19, 2006.     

Structural Studies of DNA–Cationic Lipid Complexes Confined in Lithographically Patterned Microchannel Arrays

We have used lithographically patterned microchannel arrays with channel widths ranging from 1 to 20 m, fabricated using electron beam lithography and reactive ion etching, in structural studies of DNA–cationic lipid complexes in confinement. Various techniques have been developed for loading these DNA–membrane complexes into the microchannels or to form the complexes in situ by sequentially depositing DNA and lipid solutions into the microchannels. Optical microscopy studies indicate that such complex formation is strongly influenced by the periodic channel structure even at channel widths much larger than the persistent length of the DNA molecules. Preliminary x-ray diffraction experiments conducted at Stanford Synchrotron Radiation Laboratory (SSRL) yielded only a weak signal from the lipid bilayers in the complexes. The use of a microfocused x-ray beam produced by the newly developed Bragg–Fresnel optics at a third-generation synchrotron facility may dramatically increase the signal-to-noise ratio and allow observation of orientational as well as positional ordering of DNA molecules induced by the microchannels. Structural control of the DNA–membrane complexes has a broad range of potential applications in gene probe technology and as mesoscopic biomolecular composites.     

Y型微管道中磁性纳米液体对混合率的影响

利用流动显示手段观测了Y型微管道内含纳米磁性颗粒的液体与去离子水的混合.研究了在Re=0.5～4,磁性颗粒体积分数0.38%-1.54%时,外加静磁场(场强40 Gs)对液体混合地影响.证实了磁场作用可以使完全混合长度大大缩短.同时初步分析了Re和体积分数Ψ对混合长度的影响.     

基于LTCC的微流道散热技术

简要介绍了在低温共烧陶瓷(LTCC)基板中制作微流道结构对电路散热的必要性,建立3种不同结构微流道LTCC基板有限元模型并对其进行了热-流耦合仿真,分别分析不同结构、流体流速及进出口截面对散热性能的影响.基于仿真结果制备实物,实测结果表明14 W/cm2热流密度下最高温升124.3 K,在设定水流流速为0.012 m/...     

多结构形式小通道液冷板散热性能对比研究

小通道冷板作为一种有效的热控装置,已被广泛应用于高热流密度电子器件的热管理领域。文中以通道特征尺寸为2 mm 的串行、并行以及射流冲击/小通道混合液冷板为研究对象,旨在获取这3种结构形式冷板的极限散热能力和流动阻力损失的差异。研究结果表明：在相同冷却工质流量条件下,3种冷板的散热功率由大到小依次为串行通道、并行通道、射流冲击/小通道混合液冷板;串行通道冷板的板内阻力损失明显大于其余两者;在综合考虑压力损失和散热性能的基础上,根据不同热源热流密度条件选择合适的冷板结构,有望满足特定应用的需求。该研究可供小通道液冷板的设计和优化参考。     

微细通道尺寸对甲醇水蒸汽重整反应性能影响

针对微细通道反应器内甲醇水蒸汽重整制氢反应,建立了二维稳态多组分传输反应模型.分析了通道几何尺寸的变化对产物的组成以及通道内部温度分布的影响.结果表明,通道长高比的增加能增强通道壁面与流体的换热性能,提高甲醇转化率和产物中氢含量,但同时也会造成产物中CO含量的增加,影响到质子交换膜燃料电池的正常工作.     

微通道下费托合成催化剂层涂覆厚度的数值研究

采用COMSOL-Multiphysics软件, 针对Fe基催化剂费托合成反应动力学特性, 建立了耦合流动、传热、传质、化学反应多物理场的二维数值计算单元模型, 研究微通道内的费托合成反应。重点研究了催化剂涂层厚度、冷却介质流速对微通道内传热传质、费托反应产物分布的影响规律。模拟结果表明:沿反应通道轴向方向, 催化剂涂层温度呈先升高后降低的趋势;随着催化剂涂层厚度的增加, 温度峰值出现的位置逐渐远离出口, CO转化率提高, CH₄的选择性增大, 而C₅₊的选择性逐渐减小;提高冷却介质流速有利于实现较好的温度控制, 显著降低CH₄的选择性, 提高C₅₊选择性;对于截面尺寸为0.6×0.6mm²、长度为200mm的微通道结构, 较佳的催化剂涂层厚度为0.1mm, 随着冷却侧冷却能力的增强, 较佳的催化剂涂层厚度变大。     

恒壁温下矩形微通道热沉换热特性分析

建立了恒壁温条件下矩形硅微通道热沉的三维模型,对微通道内单相层流的换热和流动特性进行了数值模拟研究,分析结果表明:沿流动方向,热沉流体域的温度梯度大于固体域的温度梯度,且最大的温度梯度出现在入口段;除恒温热沉顶面外,通道顶面的温度最大,通道底面和热沉底面的温度近似趋于定值。通道内的换热研究发现,通道侧壁面的Nu数最大,顶面与底面相差很小,角落处的Nu数趋近于0。     

微化工过程中的传递现象

微化学工程是现代化学工程学科前沿,主要研究微时空尺度下流体流动、传热、传质现象与反应规律。着重介绍近十年来微通道内气-液、液-液两相流体流动、混合与传质的理论和实验的最新研究进展,并对微化工技术的发展进行展望。