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《Journal of dairy science》2022,105(3):2439-2452
Bias in dairy genetic evaluations, when it exists, has to be understood and properly addressed. The origin of biases is not always clear. We analyzed 40 yr of records from the Lacaune dairy sheep breeding program to evaluate the extent of bias, assess possible corrections, and emit hypotheses on its origin. The data set included 7 traits (milk yield, fat and protein contents, somatic cell score, teat angle, udder cleft, and udder depth) with records from 600,000 to 5 million depending on the trait, ~1,900,000 animals, and ~5,900 genotyped elite artificial insemination rams. For the ~8% animals with missing sire, we fit 25 unknown parent groups. We used the linear regression method to compare “partial” and “whole” predictions of young rams before and after progeny testing, with 7 cut-off points, and we obtained estimates of their bias, (over)dispersion, and accuracy in early proofs. We tried (1) several scenarios as follows: multiple or single trait, the “official” (routine) evaluation, which is a mixture of both single and multiple trait, and “deletion” of data before 1990; and (2) several models as follows: BLUP and single-step genomic (SSG)BLUP with fixed unknown parent groups or metafounders, where, for metafounders, their relationship matrix gamma was estimated using either a model for inbreeding trend, or base allele frequencies estimated by peeling. The estimate of gamma obtained by modeling the inbreeding trend resulted in an estimated increase of inbreeding, based on markers, faster than the pedigree-based one. The estimated genetic trends were similar for most models and scenarios across all traits, but were shrunken when gamma was estimated by peeling. This was due to shrinking of the estimates of metafounders in the latter case. Across scenarios, all traits showed bias, generally as an overestimate of genetic trend for milk yield and an underestimate for the other traits. As for the slope, it showed overdispersion of estimated breeding values for all traits. Using multiple-trait models slightly reduced the overestimate of genetic trend and the overdispersion, as did including genomic information (i.e., SSGBLUP) when the gamma matrix was estimated by the model for inbreeding trend. However, only deletion of historical data before 1990 resulted in elimination of both kind of biases. The SSGBLUP resulted in more accurate early proofs than BLUP for all traits. We considered that a snowball effect of small errors in each genetic evaluation, combined with selection, may have resulted in biased evaluations. Improving statistical methods reduced some bias but not all, and a simple solution for this data set was to remove historical records. 相似文献
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Tomasz Pdzinski Katarzyna Grzyb Konrad Skotnicki Piotr Filipiak Krzysztof Bobrowski Chryssostomos Chatgilialoglu Bronislaw Marciniak 《International journal of molecular sciences》2021,22(9)
Within the reactive oxygen species (ROS) generated by cellular metabolisms, hydroxyl radicals (HO•) play an important role, being the most aggressive towards biomolecules. The reactions of HO• with methionine residues (Met) in peptides and proteins have been intensively studied, but some fundamental aspects remain unsolved. In the present study we examined the biomimetic model made of Ac-Met-OMe, as the simplest model peptide backbone, and of HO• generated by ionizing radiation in aqueous solutions under anoxic conditions. We performed the identification and quantification of transient species by pulse radiolysis and of final products by LC-MS and high-resolution MS/MS after γ-radiolysis. By parallel photochemical experiments, using 3-carboxybenzophenone (CB) triplet with the model peptide, we compared the outcomes in terms of short-lived intermediates and stable product identification. The result is a detailed mechanistic scheme of Met oxidation by HO•, and by CB triplets allowed for assigning transient species to the pathways of products formation. 相似文献
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通过对AAOA-MBR工艺在实际工程中的应用,分析该工艺处理城市污水的节能减排效能。实践表明AAOA-MBR工艺具有很强的抗冲击负荷能力,在进水质水量大幅度波动、且碳源匮乏的情况下,仍能取得良好的处理效果。实际工程运行四年来,厂区出水各项指标均稳定优于城镇污水处理厂污染物排放标准(GB 18918-2002)中的一级A标准,其中COD、BOD5、SS、NH3-N去除率分别达到可分别达到90.14%、98.25%、95.58%和98.2%;通过对运行期间污水处理量与耗电量相关关系进行回归分析可知,当处理水量达到设计规模时,其吨水耗电量预测为0.31kWh/m3。同时,基于对污水处理系统的沿程水质检测,优化进水水量分配和内循环回流比并进行产水泵联动改造,可进一步提高系统节能减排效果。 相似文献
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《低温学》2018
A Stirling/pulse tube hybrid cryocooler (SPC), comprised of a Stirling cryocooler as the first stage and a pulse tube cryocooler as the second stage, features the ability of shifting cooling capacity between stages by adjusting the movement of the displacer in the first stage. Such an ability allows an SPC to accommodate itself to time-varying heat loads at different temperatures, which makes it a competitive candidate in space applications. However, due to the gas coupling, there exists a significant mutual effect between stages which endows an SPC with special thermodynamic characteristics and has a significant effect on the SPC’s capability of shifting cooling capacity between stages. With the phasor analysis and the thermodynamic analysis, this paper establishes an idealized model of an SPC. The model is then used to study the effect of the second stage on the first stage and reveal the condition that an SPC is able to shift cooling capacity between stages. Also, the model is compared with a Sage numerical model and the two models are consistent on the overall trend. Though it is unable to reflect reality precisely, the idealized model can interpret the mechanism and highlight some of the essential nature of an SPC, which will eventually benefit the appropriate design of an SPC. 相似文献
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采用SPM (Sulfuric-Peroxide Mixtures, 98wt%H2SO4+30wt%H2O2)+兆声(方法1)和氧等离子体+HPM (Hydrochloric/Peroxide Mixture, 37wt%HCl+30wt%H2O2+DIH2O)+兆声(方法2)两种清洗方法对多层介质膜脉宽压缩光栅进行清洗, 并对清洗前后样品的表面元素含量、衍射效率、表面粗糙度、表面温升以及激光损伤阈值等参数进行测量以评估两种清洗方法清洗效果。在入射角70°, 脉宽12 ns, s偏振, 波长1064 nm的激光辐照下, 经过清洗方法1清洗后的光栅样品单脉冲激光损伤阈值为7.55 J/cm 2, 而方法2清洗后的样品损伤阈值为5.32 J/cm 2。另外, 虽然经过方法2清洗后样品表面杂质含量更低, 但是在衍射效率、表面粗糙度和表面温升都劣于经方法1清洗后的样品, 进一步分析发现方法2中氧等离子体清洗过程引入的Fe元素影响了其样品损伤性能和温升性能。因此, SPM清洗方法可以作为多层介质膜脉宽压缩光栅提升抗激光损伤性能的优化清洗方案。 相似文献
8.
《中国有色金属学会会刊》2021,31(12):3800-3813
The Fe−Ni−TiO2 nanocomposite coatings were electrodeposited by pulse frequency variation. The results showed that the nanocomposite with a very dense coating surface and a nanocrystalline structure was produced at higher frequencies. By increasing the pulse frequency from 10 to 500 Hz, the iron and TiO2 nanoparticles contentswere increased in expense of nickel content. XRD patterns showed that by increasing the frequency to 500 Hz, an enhancement ofBCC phase was observed and the grain size of deposits was reduced to 35 nm. The microhardness and the surface roughness were increased to 647 HV and 125 nm at 500 Hz due to the grain size reduction and higher incorporation of TiO2 nanoparticles into the Fe−Ni matrix (5.13 wt.%). Moreover, the friction coefficient and wear rate values were decreased by increasing the pulse frequency;while the saturation magnetization and coercivity values of the composite deposits were increased. 相似文献
9.
Mingqiang Cheng Erding Zhao Fangjian Jiang Xiaodong Jiang Ze Fang Feng Li Wanneng Ye Yalin Qin Yongcheng Zhang 《Ceramics International》2021,47(13):18417-18423
The materials processing history has a great influence on their properties and finally determines their application effect. In this paper, the ferroelectric, polarization-switching current, and strain properties of Mn-doped 0.75Pb(Mg1/3Nb2/3)O3-0.25PbTiO3 ceramics were studied in fresh state, aged state, and poled state, respectively. Compared with the symmetric polarization-electric-field (P-E) hysteresis loops, current-density-electric-field (J-E) curves, and bipolar electric-field-induced strain (S-E) curves in fresh state samples, asymmetric P-E loops, J-E curves, and bipolar S-E curves were obtained in poled state samples. Well-aged-state samples exhibit double hysteresis P-E loop, four peaks J-E curves, and symmetric S-E curves without negative strain. The symmetry-conforming short-range order (SC-SRO) principle of point defects and internal electric field Ei is employed to clarify the different phenomenon of three states. Results indicated that randomly oriented defect polarization PD in aged samples can reverse the spontaneous polarization PS back and result in the double hysteresis P-E loop and four peaks J-E curves. The oriented PD and resulting Ei in poled-state samples will lead to the asymmetric loops and strain memory effect. 相似文献
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