稳产国Ⅵ柴油并兼产喷气燃料技术方案的工业应用

介绍了浙江石油化工有限公司新建的3 Mt/a柴油加氢精制装置，其配套使用中国石化石油化工科学研究院有限公司开发的催化剂级配技术，并实施了可根据原料供应及市场产品需求情况灵活调整切换的2种生产技术方案。1 a的安稳生产运行结果表明:该装置以直馏柴油为主原料，通过分馏塔的馏分切割及其侧线抽出，实现了稳产国Ⅵ柴油并兼产喷气燃料技术方案的工业化应用；在实施以兼产喷气燃料为主的生产技术方案时，通过调整常一线柴油的掺炼量，不仅可以生产含硫量小于10.0 μg/g的精制柴油产品，同时兼产所得到的喷气燃料产品含硫量小于0.5 μg/g，赛波特颜色号值大于30；在实施主产精制柴油组分方案时，通过掺炼质量分数为20%~40%的催化柴油，并使所提炼得到的精制柴油组分含硫量小于6.0 μg/g的前提下，这些精制柴油组分产品既可直接作为满足国Ⅵ柴油产品出厂待售，也可作为柴油调和组分储存待用于产品的进一步优化。     

药物相互作用研究在新药研发和审评决策中的应用

药物相互作用改变了剂量效应关系，可能会降低疗效或增加毒性，是临床应用中合并用药治疗时重要的考虑因素。预测具有临床意义的药物相互作用是药物研发过程中获益风险评估的重要环节。本文概述了药物研发过程中药物相互作用研究的目的和意义，体内和体外研究的主要内容；梳理分析了2020年国家药品监督管理局（National Medical Products Administration, NMPA）和美国食品药品监督管理局（Food and Drug Administration, FDA）批准上市的新药药物相互作用研究情况，旨在为我国药物研发过程中药物相互作用研究及其监管审评提供参考。     

Cybersecurity through the lens of Digital Identity and Data Protection: Issues and Trends

The use of a secure and robust digital identification system that is capable of protecting privacy is an essential, reliable and user-friendly element for a strong cyber resilience strategy and is a source of new business opportunities and applications for banks, private sector with a return on their investment.The march towards Digital Identity is well underway therefore, focus should be on both adoption and adaption of the new structures and regulations. These are needed to govern the associated services and transactions as well as establishing laws that enforce penalties for violations.There is no doubt then that more and more entities and institutions would move to the cloud. Security challenges affecting the cloud may not be new but the mode of addressing them would be different. The authors develop a Data Colouring technique for securing data processed or stored on both cloud and non-cloud platforms. The technique combines Public Key Infrastructure (PKI), concatenated fingerprints and digital watermarking. Using this technique, data can be secured at creation or during storage and remains secure during processing.     

从战后重建到预防性保护 —— 比利时建筑遗产保护之路

本文分为两个部分,第一部分简述了比利时在不同时期的建筑遗产保护实践,主要包括:第二次世界大战后的战后重建,威尼斯宣言颁布前后的相关实践,1975年"欧洲建筑遗产年"后对"历史文物古迹"的保护延伸到对次要建筑群及其所处环境以及历史城市、村镇的整体性保护,1988年文化遗产保护管理从比利时联邦下放到弗兰芒、瓦隆、布鲁塞尔三区实行分区管理等方面;第二部分着重介绍了比利时在建筑遗产的预防性保护这块的实践,以"文物古迹监护"机构近30年的实践为例,并试图从历史、社会、经济、管理、教育等角度对预防性保护得以成功实施的原因进行了分析。     

基于心理图式的知识挖掘与创新设计——以国庆彩车设计为例

为了提高设计创新效率,本研究基于心理图式提出了国庆彩车的设计程序与方法。研究按照浅层、中层和深层的次序递进,设计心理图式划分为“造型图式”“叙事与动作图式”以及“人物和情感图式”的基本类别,并提出了综合性、时态性、差异性和集体性四类基本属性。而后结合新中国成立70周年彩车设计,对不同心理图式的应用方法和属性进行了案例分析。本文所提出的方法在设计实践中得到了实证,具有一定的实用价值。     

中国罕见病研究的现状与未来

罕见病是人类社会发展的沉重负担,对罕见病进行深入研究具有重要的社会意义和科学价值。中国人口基数巨大,为罕见病研究提供了广阔资源,同时也带来了巨大挑战。既往中国在罕见病领域取得了众多成就,同时也面临着研究力量分散、资源整合缺乏等问题。随着政府部门、学术机构、研究团体及个人对罕见病研究的重视及参与,中国罕见病研究正朝着协作、创新方向发展。未来的中国罕见病研究将从多个方面推进,为中国及世界应对罕见病挑战作出贡献。     

罗衣从风·融汇创新——国家艺术基金“敦煌服饰创新设计人才培养”项目综述

本文以2019年度国家艺术基金"敦煌服饰创新设计人才培养"项目申报和实施为依据,通过探究项目的文化特质和艺术特色,提出项目以理论先行、融汇贯通、创新设计为主导的实施要旨,分析了代表性作品的创新风格,进一步明确了敦煌服饰文化研究及创新设计的基本趋向。     

Self-adaptation of mobile systems driven by the Common Variability Language

The execution context in which pervasive systems or mobile computing run changes continually. Hence, applications for these systems require support for self-adaptation to the continual context changes. Most of the approaches for self-adaptive systems implement a reconfiguration service that receives as input the list of all possible configurations and the plans to switch between them. In this paper we present an alternative approach for the automatic generation of application configurations and the reconfiguration plans at runtime. With our approach, the generated configurations are optimal as regards different criteria, such as functionality or resource consumption (e.g. battery or memory). This is achieved by: (1) modelling architectural variability at design-time using the Common Variability Language (CVL), and (2) using a genetic algorithm that finds nearly-optimal configurations at run-time using the information provided by the variability model. We also specify a case study and we use it to evaluate our approach, showing that it is efficient and suitable for devices with scarce resources.     

兼容二元:中国县镇乡发展的基本判断与路径选择

新型城镇化的国家战略对于县、镇、乡是一次新的发展机遇。通过更大数量和更基层的县城、镇等的发展,将城市资本与数量众多的县、镇、乡的土地、劳动力等资源集合起来,能够进一步生产和扩大市场,维持社会稳定。结合城乡关系过程的政治经济分析和历史讨论,作者提出县镇乡"兼容二元"的发展路径。但县、镇、乡的发展不仅仅与市场有关,它们的发展也不仅仅是被整合入全球经济生产链的问题。它们的开放或内生性发展对于地方的文化发展、大地景观、生活方式与价值理念、环境状况等都将有巨大影响,这仍然需要进一步讨论。     

Neuroscience and architecture: What does the brain tell to an emotional experience of architecture via a functional MR study?

Environment psychologically affects individuals. According to the base of cognitive psychology, there is a direct relationship between human behavior, environment, and emotional process. Assuming that pleasantness and unpleasantness are associated with peripheral nervous system activation, the current study aims to explore if the pleasant or unpleasant architectural places can stimulate the brain regions engaged in emotions or not. As the main contribution, we used functional magnetic resonance imaging (fMRI) measuring blood oxygenation level-dependent (BOLD) changes to effectively detect the brain's region that mainly responds to the emotional-perceptual processes. Based on the results of examining the emotional assessment model of “Pleasure-Arousal” applied to 140 students, 30 most-rated images representing 15 pleasant and 15 unpleasant places were shown to 32 participants in a 1.5-T MRI scanner. After applying standard preprocessing steps (re-alignment, slice-timing, co-registration, segmentation, normalization, and smoothing) to functional MR images, first-level analysis was applied to each subject. The results were evaluated using statistical corrections at different levels for female and male participants with the second-level analysis. In conclusion, it has been shown that there is a significant linkage between environmental experience and brain activation so that the architectural qualities can change blood flow in specific brain regions.