排序方式: 共有13条查询结果,搜索用时 31 毫秒
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Juan Zhang Qiang Shen Jin-Cai Lu Jing-Ya Li Wen-Yong Liu Jian-Jun Yang Jia Li Kai Xiao 《Food chemistry》2010
Phenolic compounds were separated from the leaves of Cyclocarya paliurus (Batal.) Ijinskaja and their bioactivities were evaluated through an in vitro PTP1B inhibitory assay. Bioassay-guided fractionation of the ethanol extract has resulted in the isolation of a naphthoquinone derivative, (1R, 2R, 4R)-1,2,4-trihydroxy-1,2,3,4-tetrahydro-naphthalene-1-O-β-d-glucopyranoside, named cyclonoside A, and a lactone, (4R, 5S, 6R)-8,9,10-trihydroxy-4-[3′,4′-dihydroxyphenyl]-1,6-dioxaspiro[4,5]decan-2-one, named cyclospirolide, along with 10 known phenolic compounds: quercetin-3-O-α-d-glucuronide, quercetin-3-O-β-d-glucuronide, myricetin-3-O-β-d-glucuronide, 1-caffeoylquinic acid, 3-caffeoylquinic acid, 4-caffeoylquinic acid, 5-caffeoylquinic acid, caffeic acid, 5-hydroxynaphthalene-1, 4-di-O-β-d-glucopyranoside and piceid. The structures of these compounds were established by means of spectroscopic methods including extensive 2D NMR techniques and chemical evidence. Among all the compounds, 1, 2, 4, 5, 10 and 11 showed strong inhibition against PTP1B, with IC50 values ranging from 1.922 ± 0.480 to 10.50 ± 2.67 μg/mL. The results suggested that the extract from this plant could be used as a potential source for functional food ingredient with anti-obesity. 相似文献
2.
Kazunari Ushida Hironori Hatanaka Ryo Inoue Takamitsu Tsukahara Glyn O. Phillips 《Food Hydrocolloids》2011
Abdominal obesity is the most prevalent manifestation of metabolic syndrome. The anti-obese effects of dietary fiber is generally accepted, but specifically the anti-obese properties of the dietary fiber, gum arabic (GA) has not been well studied. In this investigation, we offered GA to the female 90 days old mice in the form of drink (1% w/v) for 180 days. Such GA in drinking water reduced age-dependent fat deposition in the visceral adipose tissue and improved the gastrocnemius muscle reduction. This inhibition of fat deposition effect is due to the β3-adrenergic stimulation of adipocytes in which TNFα down-regulation is probably involved. Modification of large intestinal microflora, as evidenced by a modification of cecal short-chain fatty acid profile and of 16S rDNA profile, may contribute to such reduction in TNFα expression in the adipose tissues. 相似文献
3.
《Journal of Bioscience and Bioengineering》2020,129(3):259-268
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Rui Liu 《International Journal of Food Properties》2013,16(10):2246-2255
Total phenolic and saponin components were extracted from 13 commonly consumed food legumes produced in China, and then a systematic comparative study was conducted to investigate their inhibitory effects against digestive enzymes, pancreatic lipase, and α-glycosidase, respectively. Saponin extract (1 mg/mL) from black bean exhibited the highest (41.8%) pancreatic lipase inhibitory effect, followed by phenolic extract from adzuki bean with 36.3%, saponin extract from yellow soybean with 34.1%, saponin extract from pinto bean with 32.6%. It is worth mentioning that both phenolic and saponin extracts from the mung bean, adzuki bean, lima bean, and pinto bean exhibited inhibitory effects against pancreatic lipase. Among four beans, the adzuki bean had the highest inhibitory effects against pancreatic lipase activity. In the α-glycosidase assays, phenolic extracts exhibited stronger α-glycosidase inhibitory activity than that of saponins in general. Phenolic extracts of the adzuki bean, black bean, fava bean, lentil, rock bean, and red kidney bean inhibited over 80% of α-glycosidase activity at the concentration of 1 mg/mL. Both phenolic and saponin extracts from the adzuki bean and rock bean exhibited inhibitory effects against α-glycosidase. The results indicate that adzuki bean is one of the best target beans for further study on their anti-obesity and anti-diabetes effects via cell and animal models. 相似文献
6.
The antioxidative activities of a lotus seed epicarp extract in different concentrations (6.25, 12.5, 25, 50 and 100 μg.mL− 1) in pork homogenates representative of Chinese Cantonese Sausage were evaluated using three methods: thiobarbituric acid-reactive substances (TBARS) values, peroxide values (POVs) and acid values (AVs). Also the cytotoxic and anti-obesity effects of the lotus seed epicarp extracts were evaluated using an in vitro 3T3-L1 preadipocyte cell model. Results showed that the lotus seed epicarp extracts were non-toxic and effective in inhibiting preadipocyte differentiation. Supplementation of pork homogenate with lotus seed epicarp extracts was effective in retarding lipid oxidation. Moreover, the antioxidative and preadipocyte differentiation inhibition effects of the lotus seed epicarp extracts were dose-dependent. Thus, the lotus seed epicarp extract might be a good candidate as an antioxidant and anti-obesity natural additive in Chinese Cantonese Sausage. 相似文献
7.
燕麦膳食纤维对食源性肥胖小鼠降脂减肥作用研究 总被引:1,自引:1,他引:1
深入研究水溶性及水不溶性燕麦膳食纤维降脂减肥作用的效果。60只昆明小鼠,饲喂高脂饲料构建肥胖模型后,分别饲喂添加低、高剂量(7.33、14.67 g·kg-1(BW)·d-1)的燕麦水溶性(SDF)水不溶性(IDF)膳食纤维的高脂饲料作为试验组,另设饲喂普通饲料和高脂饲料作为正常对照组和肥胖模型组。测定相关指标的变化。与肥胖模型组相比,肥胖小鼠在食用燕麦膳食纤维以后,Lee’s指数显著下降(P0.05),IDF效果最好;腹腔脂肪堆积显著减少(P0.05),激素敏感性脂肪酶显著升高(P0.05),同时胰岛素分泌减少促甲状腺激素分泌增加(P0.05),SDF作用效果高于IDF(P0.05);小鼠肝脏系数、肝脏总胆固醇(TC)和三酰甘油(TG)水平显著降低(P0.05),肝脏肝酯酶(HL)和脂蛋白酯酶(LPL)活性升高(P0.05),但是与正常组对照小鼠相比仍有显著差异(P0.05),SDF效果比IDF更显著。燕麦SDF和IDF都具有降脂减肥作用,存在剂量效应,但作用途径不同。 相似文献
8.
This study examines the effect of diacylglycerol (DAG) oil consisting mainly of 1,3-species on fat oxidation as a possible
mechanism for anti-obesity. We examined the following: (1) the long-term (23-week) effects of a DAG oil diet on the development
of obesity; (2) the effect of a single ingestion of DAG oil on fat oxidation; and, (3) the short-term (2-week) effect of a
DAG oil diet on fat metabolism in rats. Rats fed a DAG oil diet accumulated significantly less body fat compared to rats fed
a triacylglycerol (TAG) oil diet, each oil possesses a similar fatty acid composition. More 14C-CO2 was expired and less 14C-radioactivity was incorporated into visceral fat after administration of a tracer emulsion containing 1,3-[oleoyl-1-14C] diolein compared to [carboxyl-14C] triolein. Indirect calorimetry showed respiratory quotients were significantly lower in the DAG oil diet group than in
the TAG oil diet group. More 14C-CO2 was expired and less 14C-radioactivity was incorporated into visceral fat in the DAG oil diet group than in the TAG oil diet group after a single
intragastric administration of [carboxyl-14C] triolein. These results suggest the following. (1) DAG oil has an inhibitory effect on diet-induced fat accumulation. (2)
1,3-DAG, a major component of DAG oil, is more susceptible to oxidation. (3) A short-term ingestion of DAG oil increases fat
utilization at the whole body level and results in increased oxidation of dietary fat. The stimulated fat oxidation might
be one explanation for the anti-obesity effect of long-term DAG oil ingestion. 相似文献
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10.
《Food Control》2015
The antioxidative properties of lychee seed water extract (LSWE) in raw meat paste during a storage period of 0–15 days at 4 °C were evaluated. The cytotoxic effects and the anti-obese effects of LSWE were evaluated using an in vitro 3T3-L1 preadipocyte cell model. The sensory properties of the cooked meat paste supplemented with different amount of LSWE were also evaluated. Results showed that LSWE was non-toxic and effective in inhibiting preadipocyte differentiation. These effects were attributable to down-regulation of several adipogenesis-specific genes, i.e., PPAR γ, C/EBP α, C/EBP β, C/EBP δ, and KLF9. Supplementation with LSWE was also effective in retarding lipid oxidation of meat paste. Sensory evaluation indicated that LSWE did not adversely affect the sensory properties of the meat paste. On the contrary, LSWE significantly improved the sensory properties of the meat paste during the late stage of the storage period. Based on the results, LSWE was determined to be effective in inhibiting adipogenesis and retarding lipid oxidation, which can improve the safety and quality of meat products. 相似文献