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在适当溶剂中将所硝柳胺与乙醇胺反应,制得氯硝柳胺及乙醇胺盐,经元素分析,IR和NMR鉴定了结构。对该化全物的熔点测定进行了讨论。 相似文献
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Among the several known fatty acid‐derived chemical signals, the endogenous ligands of cannabinoid receptors type‐1 and ‐2, two G‐protein‐coupled receptors involved in several aspects of mammalian physiology and pathology, are perhaps those the levels of which have proven to be most sensitive to the fatty acid composition of the diet. The two most studied such ligands, known as endocannabinoids, are N‐arachidonoyl‐ethanolamine and 2‐archidonoylglycerol, and are found in tissues together with other N‐acyl‐ethanolamines and 2‐acylglycerols, not all of which activate the cannabinoid receptors, although several of them do exhibit important pharmacological effects. In this review article, we describe literature data indicating that the tissue concentrations of the endocannabinoids and related signalling molecules, and hence the activity of the respective receptors, can be modulated by modifying the fatty acid composition of the diet, and particularly its content in long chain PUFAs or in long chain PUFA precursors. We also discuss the potential impact of these diet‐induced changes of endocannabinoid tone on three of the major pathological conditions in which cannabinoid receptors have been involved, that is metabolic dysfunctions, inflammation and affective disorders. 相似文献
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以硬脂酸、单乙醇胺、环氧乙烷、葡萄糖为原料制备了不同环氧乙烷(EO)聚合度的硬脂酸单乙醇酰胺聚氧乙烯醚葡萄糖苷类非离子表面活性剂。该糖苷类表面活性剂在烷基和葡萄糖分子之间引入非离子表面活性剂中常见的亲水基团。通过IR和1HNMR对产物结构进行表征,并测试了该类表面活性剂的最低表面张力(γCMC)为30~38 mN/m,临界胶束质量浓度(CMC)为0.01~0.1 g/L。研究了EO聚合度(n)对产品表面物理化学性能的影响,随着n的增加,CMC、乳化性能、吸湿保湿性能均增加。不同聚合度的产物均有很好的泡沫性能和硬水稳定性。 相似文献
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Xiaosan Wang Xingguo Wang Tong Wang 《Journal of the American Oil Chemists' Society》2013,90(7):1031-1039
Arachidonoyl ethanolamide is an endogenous cannabinoid neurotransmitter that potentially has therapeutic properties. In this study, we report an enzymatic method to synthesize this bioactive ethanolamide. First, free fatty acids were obtained from arachidonic acid-rich oil and then arachidonic acid was enriched by urea inclusion and AgNO3 solution fractionation. Arachidonic acid content was increased from 40.2 to 78.4 % with 27.6 ± 1.8 % total fatty acid mass yield (w/w, relative to total free fatty acid) after urea inclusion. Purification of arachidonic acid by AgNO3 solution fractionation was optimized, and under the optimal conditions, a product with 90.7 % arachidonic acid was obtained with 80.4 % mass yield (w/w, relative to total free fatty acid). Finally, arachidonoyl ethanolamide was synthesized by reacting the purified arachidonic acid with ethanolamine in hexane using Novozym 435 lipase of Novozymes America (Blair, NE), which resulted in the formation of 88.4 ± 0.6 % arachidonoyl ethanolamide with 72.7 ± 2.2 % mass yield. The main novelties of this study are the enrichment of polyunsaturated fatty acids by AgNO3 solution fractionation which has received little attention in recent years, and this is the first time the synthesis of arachidonoyl ethanolamide is reported. 相似文献
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合成了一系列聚氧丙烯脂肪酸乙醇酰胺磺基琥珀酸单酯二钠并研究了其表面活性。结果表明 ,随氧丙烯聚合数或脂肪酸碳原子数的增加 ,临界胶束浓度减小而最小表面张力增大 ,润湿力和起泡力都下降 ,泡沫稳定性较高且变化不显著 相似文献
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研究了乙氧基化和丙氧基化十四酸乙醇酰胺磺基琥珀单酯钠盐的表面活性,结果表明,随烷氧基加聚数的增加,临界胶束浓度减小而最小表面张力增大,乙氧基化物的润湿力迅速下降,而丙氧基化物的润湿力趋于增强,二者的起泡力都下降,而泡沫稳定性都较高,变化不显著,前得的润车不及后者,二者起泡力及泡沫稳定性的差别不显著。 相似文献