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Bin Zhang Alexander K. Nguyen Roger J. Narayan Jie Huang 《Journal of the American Ceramic Society》2022,105(3):1821-1840
Novel inks were formulated by dissolving polycaprolactone (PCL), a hydrophobic polymer, in organic solvent systems; polyethylene oxide (PEO) was incorporated to extend the range of hydrophilicity of the system. Hydroxyapatite (HAp) with a weight ratio of 55–85% was added to the polymer-based solution to mimic the material composition of natural bone tissue. The direct ink writing (DIW) technique was applied to extrude the formulated inks to fabricate the predesigned tissue scaffold structures; the influence of HAp concentration was investigated. The results indicate that in comparison to other inks containing HAp (55%, 75%, and 85%w/w), the ink containing 65% w/w HAp had faster ink recovery behavior; the fabricated scaffold had a rougher surface as well as better mechanical properties and wettability. It is noted that the 65% w/w HAp concentration is similar to the inorganic composition of natural bone tissue. The elastic modulus values of PCL/PEO/HAp scaffolds were in the range of 4–12 MPa; the values were dependent on the HAp concentration. Furthermore, vancomycin as a model drug was successfully encapsulated in the PCL/PEO/HAp composite scaffold for drug release applications. This paper presents novel drug-loaded PCL/PEO/HAp inks for 3D scaffold fabrication using the DIW printing technique for potential bone scaffold applications. 相似文献
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针对传统冷却系统与柴油机冷却需求不匹配的问题,进行了冷却系统电控化设计仿真研究。基于Simulink软件设计了电控冷却系统仿真模型,提出了电控冷却控制策略,并开展了变柴油机工况条件下电控冷却控制策略验证仿真。对传统冷却部件进行电控化改造(电控海水泵、电控淡水泵和电子节温器),搭建电控冷却系统试验台架,通过试验分析了电控冷却对柴油机耗油率和热平衡的影响,结果表明:相对于传统冷却系统,电控冷却系统在900 r/min、负荷率30%,1 200 r/min、负荷率60%,1 500 r/min、负荷率90%这3个工况点的耗油率分别降低9.4 g/(kW·h)、6.8 g/(kW·h)和3.9 g/(kW·h),燃油经济性和热量分配得到改善。 相似文献
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《矿业科学技术学报(英文版)》2021,31(1):75-81
Two miners were fatally injured when a pillar bump occurred during retreat mining in a southern West Virginia coal mine. The mine was operating in the Eagle seam with overmining in the No. 2 Gas and Powellton seams. A coal bump is defined as a sudden and violent failure of coal caused by the release of stored strain energy in the pillar. While significant strides have been made by academia, industry,and regulatory agencies to better understand bump conditions and mitigation techniques, coal bumps represent a long standing, highly site-specific engineering problem in which the exact failure mechanism is not clearly understood. In this case history, a cut-by-cut analysis of retreat mining operations was conducted on the 4 East Main leading up to the pillar bump event. Numerical input parameters were derived from site-specific geologic information and mine geometry for the analysis of pillar stress conditions and energy release using LaModel. An overview of stress conditions in the panel was presented including a precursor event that occurred two crosscuts inby the bump site. The methodology presented in the paper for the evaluation of the fatal bump event can be used for the identification of bump prone conditions prior to development and retreat of a mining area. 相似文献
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Improved Controlled Release and Brain Penetration of the Small Molecule S14 Using PLGA Nanoparticles
Vanesa Nozal Elisa Rojas-Prats Ins Maestro Carmen Gil Daniel I. Perez Ana Martinez 《International journal of molecular sciences》2021,22(6)
Phosphodiesterase 7 (PDE7) is an enzyme responsible for the degradation of cyclic adenosine monophosphate (cAMP), an important cellular messenger. PDE7’s role in neurotransmission, expression profile in the brain and the druggability of other phosphodiesterases have motivated the search for potent inhibitors to treat neurodegenerative and inflammatory diseases. Different heterocyclic compounds have been described over the years; among them, phenyl-2-thioxo-(1H)-quinazolin-4-one, called S14, has shown very promising results in different in vitro and in vivo studies. Recently, polymeric nanoparticles have been used as new formulations to target specific organs and produce controlled release of certain drugs. In this work, we describe poly(lactic-co-glycolic acid) (PLGA)-based polymeric nanoparticles loaded with S14. Their preparation, optimization, characterization and in vivo drug release profile are here presented as an effort to improve pharmacokinetic properties of this interesting PDE7 inhibitor. 相似文献
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针对商用车气压制动系统快放阀排气气压延迟问题,对快放阀进行优化设计以降低延迟气压与时间。应用系统仿真软件AMESim对快放阀进行模拟仿真,获得对排气延迟影响较大的变量,利用正交试验法研究了快放阀膜片厚度、排气口流通面积、排气口气隙宽度对快放阀排气延迟的影响。结果表明:最优快放阀结构的排气口气隙宽度为3 mm,膜片厚度为2 mm,下阀口支撑筋面积为70 mm2;通过快放阀结构的参数优化,可有效降低排气延迟气压与时间,压差同比降低约110 kPa,时间缩短0.65 s,同时提升了制动系统的稳定性。 相似文献
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Chunjie Wang Hanjun Tu Ranran Su Jie Gao B. V. King D. J. O'Connor Liqun Shi 《Journal of the American Ceramic Society》2021,104(1):593-603
Cr2AlC MAX phase thin films prepared by radio-frequency magnetron sputtering were irradiated at room temperature by 100 keV helium ions to a fluence of 1 × 1017 ions cm−2. The effects of thermal annealing on the structural and mechanical properties of the helium-irradiated Cr2AlC films as well as the helium release were investigated by grazing-incidence X-ray diffraction (GIXRD), Raman spectroscopy, and scanning electron microscope (SEM) in combination with nano-indentation and elastic recoil detection (ERD) analysis. The irradiation-induced structural damage in the Cr2AlC is significantly recovered by thermal annealing at temperatures around 600℃, attributed to high defect diffusivity. After annealing to 750℃, the hardness of irradiated films recovered almost completely, which is ascribes to both defect recombination and reformation of damaged chemical bonds. Substantial helium release occurring at this annealing temperature is closely related to the damage recovery due to helium irradiation. 相似文献