提升管内颗粒浓度梯度力的特性

由于Kutta-Joukowski横向力与浓度梯度力的共同作用，提升管内颗粒沿径向在边壁大量聚集并形成稳定的环?核结构。根据实验数据，分析了颗粒浓度梯度的径向分布特征，考察了不同操作条件下浓度梯度力系数K的分布特性。由Kutta-Joukowski横向力与浓度梯度的关系，提出了浓度梯度力的表达式Fρ=K(dρ/dr)A及浓度梯度力系数K的表达式K=[?ρg(νg?νp)(?v/?r)r]/?dρ/dr+(d2ρ/dr2)r?。提升管内颗粒群受到的浓度梯度力与浓度梯度力系数K有关。浓度梯度力系数K在提升管中心处为0，沿提升管径向呈“N”型分布，随表观气速增加而增加；提升管内充分发展段K的数值明显大于提升管加速区和出口约束区，总结了浓度梯度力系数K的经验关联式。     

Mathematical formulation and heuristic algorithms for optimisation of auto-part milk-run logistics network considering forward and reverse flow of pallets

The operational planning of distribution network for automotive industry is complex with many conditions to consider, including heterogeneous fleet, enforcing the feasibility of 3D-packing of pallets into vehicles to address the vehicle's capacity in terms of weight and volume, compatibility of orders in a vehicle, returning empty pallets from assembly-plants backwards to suppliers, and delivery time windows. A mathematical model (MILP) is proposed that takes account of these conditions to minimise total transportation costs. The network structure can be a combination of direct shipment and milk-run for both forward and reverse flow of pallets. The model is solved optimally for small-size problems. For solving larger problems, a heuristic algorithm (in two versions) is proposed that uses a similarity measure to generate a reasonable list of orders. Best/first-fit strategies are employed to generate a feasible solution with the aid of a relaxed version of the proposed MILP. Improvement heuristics are also designed. Unlike most of existing constructive heuristics, our aim for developing the heuristic approach is to force routing decision, with all of its considerations, being made optimal. We also use the proposed best-fit strategy in the body of grouping evolution strategy (GES) algorithm to attain an effective meta-heuristic approach. The effectiveness of heuristics is tested on generated instances which demonstrates they are optimal for small-size problems. They are also tested on the data of daily auto-parts shipments gathered from the largest Iranian automobile company. Results demonstrate there exists a significant potential for cost saving through milk-run strategy compared with the direct shipping strategy.     

Formulation strategy towards minimizing viscosity mediated negative food effect on disintegration and dissolution of immediate release tablets

Food induced viscosity can delay disintegration and subsequent release of API from solid dosage form which may lead to severe reduction in the bioavailability of BCS type III compounds. Formulations of such tablets need to be optimized in view of this postprandial viscosity factor. In this study, three super disintegrants, croscarmellose sodium (CCS), cross-linked polyvinylpolypyrrolidone (CPD), and sodium starch glycolate (SSG) were assessed for their efficiency under simulated fed state. Tablets containing these disintegrants were compressed at 10 and 30?KN, while taking lactose as a soluble filler. In addition to other compendial tests, disintegration force of these formulations was measured by texture analysis. Comparison of parameters derived from force – time curves revealed a direct relation of maximum disintegration force (F_max) and disintegration force development rate (DFDR) with compressional force in fasted state, whereas an inverse relationship of F_max and DFDR with compressional force was observed in fed state. The gelling tendency of disintegrants influenced the rate of release of API in simulated fed and fasted states when compressional force was changed. These observations recommend the evaluation of formulations in simulated fed state, in the development stage, with an objective of minimizing the negative impact of food induced viscosity on disintegration. Use of disintegrants that act without gelling or can counteract the effect of gelling is recommended for tablet formulations with reduced disintegration time (DT) and mean dissolution time (MDT) in fed state, respectively.     

Formulating Pantone colors by unused base inks,formulation software,and a spectrophotometer

Unused base inks that are not going to be used for printing production are considered to be hazardous materials. Their disposal is expensive, and strict environmental regulations should be followed for their disposal. As an alternative, this article describes how spectral data of unused base inks can be gathered and mixed to generate new colors to incorporate them back to print production for small‐volume jobs. In this study, 30 different Pantone colors were selected as target colors. The CIE L*a*b* spectral data of Pantone colors and unused base inks were gathered via a spectrophotometer. A commercial formulation software, based on multiflux theory and CIE L*a*b* color space, was used to formulate ink recipes that contained the base inks. To quantify the performance of ink recipes, they were mixed and printed using an offset printability tester. The CIELAB ΔE*_ab metric, developed by CIE, was used to detect the visual differences between the target Pantone Color and printed colors.     

Exploitation of microbial antagonists for the control of postharvest diseases of fruits: a review

Fungal diseases result in significant losses of fruits and vegetables during handling, transportation and storage. At present, post-production fungal spoilage is predominantly controlled by using synthetic fungicides. Under the global climate change scenario and with the need for sustainable agriculture, biological control methods of fungal diseases, using antagonistic microorganisms, are emerging as ecofriendly alternatives to the use of fungicides. The potential of microbial antagonists, isolated from a diversity of natural habitats, for postharvest disease suppression has been investigated. Postharvest biocontrol systems involve tripartite interaction between microbial antagonists, the pathogen and the host, affected by environmental conditions. Several modes for fungistatic activities of microbial antagonists have been suggested, including competition for nutrients and space, mycoparasitism, secretion of antifungal antibiotics and volatile metabolites and induction of host resistance. Postharvest application of microbial antagonists is more successful for efficient disease control in comparison to pre-harvest application. Attempts have also been made to improve the overall efficacy of antagonists by combining them with different physical and chemical substances and methods. Globally, many microbe-based biocontrol products have been developed and registered for commercial use. The present review provides a brief overview on the use of microbial antagonists as postharvest biocontrol agents and summarises information on their isolation, mechanisms of action, application methods, efficacy enhancement, product formulation and commercialisation.     

Model for practical prediction of natural carbonation in reinforced concrete: Part 1-formulation

A model is proposed for prediction of natural carbonation in reinforced concrete (RC) structures, and is potentially applicable to existing and new RC structures. The major components of the model comprise mathematical functions applied to predict the influence of concrete composition, and environmental factors on natural carbonation.This paper introduces the model concept and explains its structure including derivation, optimization and calibration. Over 163 data sets taken from a 10-year carbonation study were used in the model development and calibration. Only the experimental data that were based on outdoor natural exposure environment were employed in this research. Also in this study, the proposed model is compared with fib-Model Code 2010 using carbonation predictions generated from 346 data sets involving real world, highway structures. It is shown that the proposed model is comparably accurate and involves mainly basic tests with no major anticipated costs.     

A variable neighborhood search heuristic algorithm for the double vehicle routing problem with multiple stacks

This paper addresses the double vehicle routing problem with multiple stacks (DVRPMS) in which a fleet of vehicles must collect items in a pickup region and then travel to a delivery region where all items are delivered. The load compartment of all vehicles is divided into rows (horizontal stacks) of fixed profundity (horizontal heights), and on each row, the unloading process must respect the last‐in‐first‐out policy. The objective of the DVRPMS is to find optimal routes visiting all pickup and delivery points while ensuring the feasibility of the vehicle loading plans. We propose a new integer linear programming formulation, which was useful to find inconsistencies in the results of exact algorithms proposed in the literature, and a variable neighborhood search based algorithm that was able to find solutions with same or higher quality in shorter computational time for most instances when compared to the methods already present in the literature.     

亮色系建筑涂料色浆的研制及应用

阐述了自制亮色系色浆的必要性。介绍了自制亮色系色浆的颜料筛选,配方调整及其在建筑涂料中应用后对面漆性能的影响。     

Design of novel urogenital pharmabiotic formulations containing lactobacilli,salivaricin CRL 1328 and non-microbial compounds with different functionalities

Context: The administration of pharmabiotics is a promising alternative to antimicrobial drugs for the treatment and/or prevention of female urogenital infections.

Objective: To design pharmabiotic formulations including bioactive ingredients of microbial origin combined with non-microbial substances and then to evaluate the stability of the combinations during freeze-drying and storage.

Materials and methods: Different formulations including Lactobacillus gasseri CRL 1263, Lactobacillus salivarius CRL 1328, salivaricin CRL 1328 (a bacteriocin) and non-microbial compounds (lactose, inulin and ascorbic acid) were assayed, and the ingredients were freeze-dried together or separately. The formulations were stored in gelatin capsules at 4?°C for 360?d.

Results: The viability of lactobacilli was affected to different extents depending on the strains and on the formulations assayed. L. salivarius and ascorbic acid were successfully combined only after the freeze-drying process. Salivaricin activity was not detected in formulations containing L. gasseri. However, when combined with ascorbic acid, lactose, inulin or L. salivarius, the bacteriocin maintained its activity for 360?d. The selected microorganisms proved to be compatible for their inclusion in multi-strain formulations together with lactose, inulin and ascorbic acid. Salivaricin could be included only in a L. salivarius CRL 1328 single-strain formulation together with non-microbial substances.

Conclusions: This study provides new insights into the design of urogenital pharmabiotics combining beneficial lactobacilli, salivaricin CRL 1328 and compounds with different functionalities.