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1.
In this study, the optimised β-carotene loaded nanostructured lipid carriers (NLC) were prepared using the solvent diffusion method. Response surface methodology (RSM) was employed in conjunction with a central composite design (CCD) to evaluate the effect of the preparation variables on particle size and β-carotene stability to optimise the NLC formulation. Quadratic polynomial was the best fitted mathematical model for the experimental results. The statistical evaluations revealed that the lipid phase concentration and the surfactant concentration had significant effect on particle size of NLC. In addition, the influence of the liquid lipid to total lipid ratio and temperature on β-carotene degradation was more important. The optimum formulations with minimum particle size (8–15 nm) and low β-carotene degradation (0–3%) were derived from the fitted models and were experimentally examined which demonstrated a reasonable agreement between experimental and predicted values. Transition electron microscopy (TEM) observations exhibited spherical morphology of β-carotene loaded NLC.  相似文献
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目的解决苯乙基间苯二酚的不稳定性及水溶性差的问题。方法采用热高压均质法制备得到苯乙基间苯二酚纳米结构脂质载体(NLC),通过考察其平均粒径、zeta电位、光稳定性和长期储存稳定性等物理化学稳定性,阐明了苯乙基间苯二酚NLC的稳定性和水溶性。结果优化条件下制备的苯乙基间苯二酚NLC平均粒径为(500±35)nm,多分散性指数(PDI)为0.098,平均包封率和载药量分别为96.9%±0.3%和4.95%±0.03%。结论热高压均质法制备的苯乙基间苯二酚NLC具有良好的稳定性,可与去离子水以任意比例稀释,且所用载体NLC对药物有很高的包封率,保证了药物的有效利用度,可广泛用于化妆品配方。  相似文献
3.
The antioxidative and photoprotective properties of vitamin E have caused it to be included as an active agent in various pharmaceutical and cosmetic products. However, its lipophilicity, chemical instability and poor skin penetration have limited the effectiveness of these formulations. For that reason, many attempts to include it in different drug delivery systems have been made. In recent decades, lipid nanoparticles have received special attention due to their advantages of compatibility with the skin, ability to enhance penetration of drugs in the stratum corneum, protection of the encapsulated substance against degradation induced by the external medium and control of drug release. This work reviews the current status of the encapsulation of vitamin E in lipid nanoparticles. We describe the most important methods for obtaining and characterizing lipid nanoparticles containing vitamin E (LNP‐VE), various techniques for the evaluation of vitamin E's properties after encapsulation, the main in vitro and in vivo studies of the potential effectiveness or toxicity of LNP‐VE, the formulations and stability studies of this delivery system, the commercial products based on LNP‐VE and the regulatory aspects related to lipid nanoparticles. Finally, we discuss the most relevant advantages of encapsulating vitamin E in such particles and critical aspects that still demand attention to enhance the potential of solid lipid nanoparticles to deliver vitamin E.  相似文献
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Nanostructured lipid carriers (NLCs) and chitosan‐coated NLCs (CH‐NLCs) were prepared by a combined double emulsion and melt dispersion method. The physicochemical properties of them were investigated to determine the optimum conditions. At 3% emulsifier concentration, the NLCs showed about 191.0 ± 4.1 nm mean particle size and low polydispersity index value compared to those observed under other conditions. The encapsulation efficiency of CH‐NLCs was 83.9% which was about 10% higher than that of NLCs. In vitro release test showed that low release amount of iron from the NLCs (11%) and CH‐NLCs (5%) in simulated gastric condition within 3 h, whereas the iron release amounts of the NLCs and CH‐NLCs were high (over 77%) in simulated intestinal condition because both NLCs and CH‐NLCs were totally destructed in the intestinal condition after 3 h. In the thiobarbituric acid test, the absorbance of milk‐fortified NLC and CH‐NLCs was lower than that of original milk. Based on these results, CH‐NLCs showed great potential for iron fortification in milk.  相似文献
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This work investigated the suitability of lipid carriers as potential encapsulation method to improve the physical and chemical stability of microalgae oil high in docosahexaenoic acid (DHA). Lipid carriers with various oil contents were successfully prepared by a microfluidization method using stearic acid as solid lipid, microalgae oil as liquid lipid, and poloxamer 188 as surfactant. Results show that the mean particle diameter of the lipid carriers was in the range of 300 to 350 nm with the polydispersity index below 0.2. The lipid carriers were found to have spherical shape when examined under the transmission electron microscope. Data from the encapsulation efficiency and loading capacity indicate high distribution of microalgae oil throughout the lipid carriers and good physical stability as reflected by the particle size and size distribution during storage. Furthermore, the lower DPPH scavenging activity of lipid carriers compared with that of free microalgae oil suggests better chemical stability of microalgae oil encapsulated in lipid carriers. The addition of microalgae oil into lipid phase could disturb the crystalline order and form lattice defects to enable encapsulation of DHA as revealed by the results from differential scanning calorimetery. Current results suggest that this type of novel lipid carriers could be an efficient and promising carrier system for delivery of microalgae oil.  相似文献
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Nanostructured lipid carriers (NLCs) are potential active delivery systems based on mixtures of solid lipids and liquid oil. In this paper, aqueous dispersions of NLCs were prepared by a hot high-pressure homogenization technique using carnauba wax as the solid lipid and isodecyl oleate as the liquid oil. The preparation and stability parameters of benzophenone-3-loaded NLCs have been investigated concerning particle size, zeta potential and loading capacity to encapsulate benzophenone-3, a molecular sunscreen. The current investigation illustrates the effect of the composition of the lipid mixture on the entrapment efficiency, in vitro release and stability of benzophenone-3-loaded in these NLCs. A loading capacity of approximately 5% of benzophenone-3 (m(BZ-3) /m(lipids) ) was characteristic of these systems.  相似文献
10.
ABSTRACT:  Nanostructured lipid carriers (NLC) technology was used to disperse hydrophobic β-carotene in an aqueous phase. NLC are lipid nanoparticles with a particle matrix consisting of a blend of a liquid and solid lipid. They were produced by melting the lipid blend at 80 °C and dispersing it into a hot emulsifier solution. The aim of this study was to extend the limited knowledge of melt-emulsified lipidic colloids in food systems and to evaluate the feasibility for further applications as functional ingredient in beverages. Physical stability of the NLC suspension was examined at 2 different storage temperatures by measuring the particle size with photon correlation spectroscopy (PCS) and laser diffractometry (LD). All particles containing sufficient amounts of emulsifier were smaller than 1 μm (LD diameter 100%) at a mean particle size of around 0.3 μm (LD) for 9 wk at 20 °C and at least 30 wk at 4 to 8 ° C. Differential scanning calorimetry (DSC) was used to study the solid state of the lipids both in the β-carotene loaded PGMS and in the NLC particles. Propylene glycol monostearate (PGMS) when dispersed as NLC recrystallized up to 98% during storage time. Within the regarded period of 7 mo no polymorph transitions were observed. Furthermore, stability of the β-carotene in water dependent on NLC concentration and tocopherol content was measured photospectrometrically to get an estimation of the behavior of NLC in beverages.  相似文献
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